RE Chapter 14 Flashcards
Graham’s Law
The rate of gas diffusion through an orifice (effusion) is inversely proportional to the square route of its molecular weight
r=1/√ mw
*faster diffusion for smaller molecules
Henry’s Law
At a constant temp, the amount of gas dissolved in a liquid is directly proportional to the partial pressure of the gas at equilibrium above the gas-liquid interface
p=kc
**(p is partial pressure, k is henry’s constant, c is concentration of solute in solution)
What five factors determine diffusion?
Directly proportional: concentration gradient, tissue area, fluid tissue solubility
indirectly proportional: membrane thickness, molecular weight
What is osmosis?
The movement of water across a semipermeable membrane to equilibrate a concentration gradient
What is osmotic pressure?
The force needed to stop osmosis
What is oncotic pressure?
The osmotic pressure by plasma proteins & electrolytes in capillaries.
What is normal oncotic pressure?
28 mmhg
Fick’s Law
Diffiusion of a gas across a semipermeable membrane is directly proportional to the partial pressure gradient, membrane solubility of the gas, & membrane area. It is inversely proportional to the membrane thickness and molecular weight.
Fick equation for diffusion of respiratory gases
J=αD/∆x(Pao2 - Pacapo2)
J - diffusion flux α - solubility constant for o2 D - diffusivity ∆x - membrane thickness (Pao2-Pcapo2) - alveolar-capillary o2 partial pressure difference
What is the force of gravity?
9.81 m/sec/sec
One newton =
1/9.81 kg wight or 102 g weight
What is the formula for force?
F=ma
m-mass
a-acceleration
What is a dyne?
1/1000th of a newton
Normal PVR
100 - 200 dyne sec/cm^5
Formula for calculating SVR
80 x (MAP-CVP)/CO
Normal SVR
900-1200 dyne sec/cm^5
Definition of pressure
force over area
P = f/a
What is a pascal?
Standard unit of measurement
Pa=1 N/ 1 m²
1 torr = _____ mmHg
1
1 kPa = ______ cm H2O = _______ mmHg
1 kPa = 10.2 cm H2O = 7.5 mmHg
gage pressure =
absolute pressure - atmospheric pressure
at sea level, 760-760= 0
What is absolute zero?
0º K
Celsius to kelvin
K = C + 273
Celsius to Fahrenheit
F = 1.8(C) + 32
What is standard temperature?
273.15 K (0º C)
What are the 4 primary mechanisms of body heat loss?
- Radiation
- Convection
- Conduction
- Evaporation
What is the most common source of heat loss? The least?
Most common is radiation, least is evaporation
What is latent heat of vaporization?
the amount of heat energy per unit mass required to convert a liquid into the vapor phase.
The rate of vaporization depends on what three things?
- Temperature
- Vapor pressure of the liquid
- Partial pressure of the vapor above the evaporating liquid
Vapor pressure of isoflurane
238 mmHg
Vapor pressure of sevoflurane
160 mmHg
Vapor pressure of desflurane
660 mmHg
Universal Gas Law
PV=nrT
P-pressure V-volume n-number of moles r-constant T - temp in K
r (constant in universal gas law) =
0.08221 L x atm / K / mol
One mole of any gas at 0º C will expand to _____ liters volume
22.4 (standard molar volume)
With n held constant the universal gas law is….
P1V1/T1 = P2V2/T2
Boyle’s law
Pressure & Volume are indirectly proportional
P1V1=P2V2