RDS and BPD Flashcards
When is prophylactic surfactant administered?
administered after initial stabilization about around 15 minutes after birth
When is rescue surfactant administered?
When clinical signs and symptoms of RDS are present and surfactant indications are met
What evidence supports redosing surfactant?
shown to improve oxygenation, decrease ventilatory requirements, and decrease risks of air leaks
How is surfactant administered?
- ETT
- LMA
How is surfactant dosed?
manufacturer specific, 75-100 mg/kg
How should the infant be positioned for surfactant replacement therapy?
Rotate infant to have the side being administered be down, rapidly deliver surfactant, wait ten seconds, rotate sides and repeat
What are the indications for surfactant replacement therapy?
- RDS
- Pulmonary hemorrhage
- meconium aspiration syndrome
- PNA and sepsis
- Congenital diaphragmatic hernia MAYBE
What are complications associated with surfactant delivery?
- transient airway obstruction
- hypoxia
- bradycardia
Define respiratory distress syndrome
severe impairment of respiratory function due to a decrease in surfactant production which causes low alveolar compliance
what is the primary etiology of RDS?
underdevelopment of the lung related to prematurity
Describe the pathophysiology of RDS
- Surfactant deficiency
- Decreased surface area for gas exchange
- Thick AC membrane
- Overly compliant chest wall
- Under developed vascularization
- Pulmonary edema
How does RDS present?
- Respiratory distress within minutes or hours after birth
- Apnea, tachycardia, nasal flaring, grunting, intercostal and subcostal retractions, cyanosis, bradycardia, hypoxemia
What does the CXR of an infant with RDS look like?
- reticulogranular pattern
- rough grainy appearing lung tissue
- ground glass
- peripheral air bronchograms
- Alveolar collapse-low lung volumes
How is RDS managed?
- Prevention of premature delivery
- corticosteroids
- Proper delivery room management
- surfactant replacement therapy
- Respiratory support as needed
- Mechanical ventilation
What are infants with RDS at increased risk for?
air leak syndromes