RC Peds lists Flashcards
Clinical features of hypercalcemia
- Bony pain
- Nephrocalcinosis/nephrolithiasis
- Abdominal pain
- Polyuria/polydypsia
- Mood lability
Ddx secondary amenorrhea
- Pregnancy
- Polycystic ovary syndrome
- Hypo/hyperthyroidism
- Athlete’s triad (amenorrhea, osteopenia, disordered eating)
- Primary ovarian failure
- Anorexia nervosa
- Prolactinoma
Features suggesting basilar migraine
- Dizziness, vertigo
- Visual disturbances, diplopia
- Ataxia
- Tinnitus
- Dysarthria
- Decreased hearing
- Simultaneous bilateral parasthesias
Ddx linear growth delay and amenorrhea
- Turner syndrome
- Celiac disease
- Hypothyroidism
- Anorexia nervosa
- Inflammatory bowel disease
- Type 1 diabetes
Clinical features of neonatal thyrotoxicosis
- IUGR
- Goitre
- Exopthalmos
- Restlessness, irritability, hyperactivity
Cyanotic heart lesions with decreased pulmonary markings
- Tricuspid atresia
- Ebstein’s anomaly
- TOF
- Pulmonary atresia
Side effects of prostaglandin
- Apnea
- Hypotension
- Hyperthermia
- NEC/decreased gut perfusion
- Gastric outlet obstruction
- Skeletal changes
Causes of linear growth delay
- GH deficiency
- Celiac disease
- Hypothyroidism
- Constitutional growth delay
- Familial short stature
- Turner syndrome
- IBD
- NF1
- Anorexia
Causes of false positive sweat chloride
- Eczema
- Malnutrition/failure to thrive
- Anorexia nervosa
- CAH
- Adrenal insufficiency
- Hypothyroidism
- Nephrogenic DI
- Klinefelter syndrome
- Caregiver fabricated illness
- Ectodermal dysplasia
Ddx leukoria
- Retinoblastoma
- Cataracts
- Persistent fetal vasculature
- Retinopathy of prematurity
- Coat’s disease
Indications for headache imaging
- Focal neurologic symptoms on exam
- Associated neurological symptoms (eg. vision changes, ataxia)
- Papilledema on exam
- Headache on first awakening
- Pain wakens from sleep
- Sudden onset or thunderclap headache
- Pain worse with cough or valsalva
- Persistent morning time nausea/vomiting with headahce
Sequelae of lyme disease besides erythema migrans
- Facial nerve palsy
- Meningitis
- Heart block
- Arthritis
Ddx blueberry muffin rash
- Congenital CMV
- Congenital rubella
- Hemolytic disease of the newborn
- AML
- LCH
Complications of varicella
- Pneumonia
- Acute cerebellar ataxia
- Stroke
- Necrotizing fasciitis
- Thrombocytopenia
Causes of anemia in chronic renal disease
- Nutritional deficiency
- Frequent blood draws
- Hemolysis from dialysis equipment
- Decreased erythropoeitin production
- Chronic inflammation
- Impaired iron metabolism
Factors that increase risk of adverse outcomes in acute head injury
- GSC 5 or less
- Raised intracranial pressure
- Presence and severity of additional injuries
- Pre-existing ADHD
- Socioeconomic status
Extraintestinal manifestations of crohn’s
- Oral mucosal ulcerations
- Growth deficiency
- Delayed sexual maturation
- Erythema nodosum
- Fistulas
Reasons for a false positive TB test
- Latent TB
- Previous BCG vaccination
- Misread or incorrect technique
- Non-tuberculous mycobacterial infection
Bad prognostic indicators in CF
- Female
- Colonization with virulent organisms (burkholderia, pseudomonas, MRSA)
- Diabetes mellitus
- Malnutrition
- Cor pulmonale
- Pneumothorax
- Worsening pulmonary function
Reasons for failing inhaled corticosteroids
- Inadequate dose
- Poor adherence/technique
- Ongoing exposure to environmental triggers
- Untreated comorbidities (allergic rhinitis, GERD, OSA)
Complications of type 2 diabetes
- Retinopathy
- Nephropathy
- Neuropathy
- Dyslipidemia
- PCOS
- Non-alcoholic fatty liver disease
- Hypertension
Complications of GERD
- Erosive esophagitis
- Strictures
- Barrett’s esophagus
- Respiratory symptoms
- Dental erosions
Physical exam findings in allergic rhinitis
- Allergic shiners
- Mouth breathing
- Horizontal nasal crease
- Performing the allergic salute
- Pale, enlarged nasal turbinates
- Dennie Morgan lines
Medications for constipation maintenance
- PEG
- Docusate
- Milk of magnesia
- Lactulose
- Mineral oil
Inherited causes of clotting
- Protein C deficiency
- Protein S deficiency
- Factor V Leiden
- Antithrombin deficiency
- Homocystinuria
Advantages and disadvantages of IgE-specific testing (RAST)
Advantages:
1. Not affected by use of corticosteroids or antihistamines
2. No risk of systemic reaction
3. Can be performed if patient has skin disase
Disadvantages:
1. False positives if elevated total IgE
2. Less sensitive than skin prick testing
3. More expensive than skin prick testing
Contraindications to breast feeding
- Active TB (treat for 2 weeks)
- HIV
- Brucellosis
- Mastitis or abscess with pus (don’t feed from that breast)
- High-dose flagyl (wait 12-24 hours after dose)
- HSV on the breast (avoid direct breast feeding until lesions crusted over)
Skin findings in IBD
- Erythema nodosum
- Pyoderma gangrenosum
- Polyarteritis nodosa
- Psoriasis
- Perianal skin tags
- Epidermolysis bullosa acquisita
- Sweet syndrome
Clinical features of rickets
- Frontal bossing
- Genu varus
- Delayed fontanelle closure
- Rachitic rosary
- Delayed tooth eruption
- Craniotabes
- Bone pain
- Widening of wrists and ankles
At risk for OSA
- Down’s syndrome
- Obesity
- Adenotonsillar hypertrophy
- Choanal atresia
- Deviated nasal septum
- Micrognathia/retrognathia
- Craniofacial trauma
- Achondroplasia
Chest x-ray findings in RDS
- Decreased lung volumes
- Ground glass opacities
- Air bronchograms
Indications for lymph node biopsy
- Persistent fever
- Failure to respond to 2 weeks of antibiotics
- Systemic symptoms such as weight loss or bony pain
- Diffuse lymphadenopathy
- Not decreasing in size after 4-6 weeks
- Mediastinal mass
- CBC concerning for hematologic malignancy
Poor asthma control
- 4 or more daytime symptoms per week
- 1 or more nighttime symptoms per week
- Physical activity limitations
- Hospital admissions
- Missing school
- 4 or more rescue therapy per week
- ICU admissions
Clinical signs of increased ICP
- Papilledema
- Cushing’s triad (hypertension, bradycardia, resp changes)
- Vertical gaze palsy (Parinaud syndrome)
- Vision changes (vision loss, diplopia)
- Altered LOC
- Headache and/or vomiting on first awakening
Conditions at risk for brain tumours
- Neurofibromatosis type 1
- Tuberous sclerosis
- Gorlin syndrome
- Li-Fraumeni syndrome
- Von Hippel-Landau
Causes of excess ADH
- Intracranial lesion
- Intrathoracic lesion
- Post-operative
- Pain
- Nausea
- Medications (morphine)
Acute complications of IBD
- Small bowel obstruction
- Intraabdominal abscess
- Fistula
- Sclerosing cholangitis
Indications for antibiotics in human bites
- Deep wounds
- Signs of infection
- Bite on hand, face, feet or genitalia
- Immunocompromised
- Wound extending to bone or joint
- Wound requiring surgical repair
Manifestations of CF
- Sinus infections
- Nasal polyps
- Bronchiectasis
- Pneumothorax
- Hemoptysis
- Meconium ileus
- Pancreatic insufficiency
- Malabsorption
- Failure to thrive
- Biliary obstruction
- Insulin-dependent diabetes mellitus
- Distal intestinal obstruction syndrome
- Rectal prolapse
- Male infertility
- Congenital absence of the vas deferens
Cyanotic heart lesions with a murmur
- Truncus
- TOF
- Tricuspid atresia
- TAPVR
- Ebstein’s
Clinical features of iron deficiency anemia
- Pallor
- Neurocognitive dysfunction
- Restless leg syndrome
- Breath holding spells
- Seizures
- Stroke
Ddx primary amenorrhea
- Turner syndrome
- Hypothyroidism
- Pregnancy
- Celiac disease
- Imperforate hymen
- Anorexia nervosa
- Inflammatory bowel disease
- Complete androgen insensitivity
Ddx constipation
- Hirschprung’s
- Hypothyroidism
- CF
- Celiac disease
- Hypercalcemia
- Hypokalemia
- Anal stenosis
- Pelvic mass
- Spinal cord abnormalities
- Abnormal abdominal musculature
Management of fulminant hepatic failure
- Transfer to a tertiary care centre
- Avoid hypovolemia
- Avoid sedatives, which may aggravate or precipitate encephalopathy
- Monitor liver function parameters
- Restrict protein intake
- Monitor closely for signs of SBP
Who should get surfactant?
- RDS and intubated (give prior to transport)
- MAS and intubated on FiO2 50% or more
- Sick with pneumonia and oxygenation index >15
- Intubated with pulmonary hemorrhage and clinical deterioration
- Significant risk of RDS (prophylactic surf)
Ductal-independent cyanotic heart lesions
- HLHS
- Truncus
- TAPVR
- TGA
Types of intussusception not reducible by air enema
- Lymphosarcoma
- Polyp
- Meckel’s diverticulum
- Small bowel intussusception
Candidates for fundoplication
- Recurrent aspiration
- Refractory esophagitis
- Barrett’s esophagitis
- Reflux-associated apnea
- Reflux-associated failure to thrive
Early warning signs of CP
- Persistent primitive reflexes
- Motor tone abnormalities (fisting, poor head control, oromotor patterns)
- Delayed motor milestones (not sitting at 8 months, not walking at 18 months, commando crawling)
- Early hand preference (< 18 months)
Recommendations for steroids in CLD
- Don’t use steroids in the first 7 days of life
- Don’t use high-dose dex to prevent or treat CLD
- Don’t routinely use low-dose dex on ventilated infants > 7 days
- Don’t use hydrocortisone
- Don’t use inhaled corticosteroids to prevent CLD
- Weigh the risks and benefits of steroids - may use 7-10 days low-dose dex or inhaled steroids for severe CLD
Questions on history for allergic rhinitis
- Nasal symptoms? Eg. itching, rhinorrhea, blockage, sneezing
- Eye symptoms? Eg. tearing, itchiness
- Environmental exposures? Eg. pets, seasonal
- Personal history of atopy?
- Family history of allergic rhinitis?
Red flags for constipation
- Onset under 1 month of age
- Delayed passage of meconium
- Ribbon stools
- Bloody stool
- Failure to thrive
- Bilious vomiting
- Severe abdominal distension
- Perianal fistula
- Absent anal or cremasteric reflexes
Disorders associated with celiac disease
- Type 1 diabetes
- Hypothyroidism
- Turner syndrome
- Trisomy 21
- William syndrome
- Autoimmune hepatitis
Ddx neonatal unconjugated hyperbili
- Breastfeeding jaundice
- Breast milk jaundice
- Blood-group incompatibility
- G6PD deficiency
- Crigler-Najjar
- Hypothyroidism
- Cephalohematoma
- Trisomy 21
Non-pharmacologic interventions for GERD
- Upright positioning after eating
- Avoid acidic or reflux-inducing foods
- Lose weight if overweight
- Smoking cessation
- Hypoallergenic diet
- Surgery - fundoplication
Risk factors for liver disease in intestinal failure
- Young age
- Long duration of TPN
- Short gut syndrome
- Lack of enteral feeding
- Intercurrent infections
Features of pertussis specific to adolescents
- Chronic cough
- Inspiratory whoop
- Sequelae of forceful coughing- rib fractures, hernias, syncope
Reasons for a false negative TB test
- HIV
- Recent infection
- Active TB
- Mumps, measles or varicella infection
- Fungal infection
- Immunosuppression
Blood work for growth delay
- Bone age
- TSH and free T4
- CBC
- Celiac screen
- IGF-1
- Urinalysis
Ddx 46XY with ambiguous genitalia
- Partial androgen receptor insensitivity
- 5-alpha reductase deficiency
- Leydig cell failure
- Gonadal dysgenesis
- CAH
Ddx neonatal thrombocytopenia
- Maternal ITP
- Neonatal alloimmune thrombocytopenia
- TAR syndrome
- Congenital CMV
- Sepsis
- Fanconi anemia
- Wiskott Aldrich syndrome
Complications of AOM
- Mastoiditis
- Facial nerve palsy
- Cranial nerve VI palsy
- Labrynthitis
- Venous sinus thrombosis
- Meningitis
- Cholesteatoma
Cyanotic heart lesions with increased pulmonary markings
- TGA
- HLHS
- TAPVR
- Truncus
Advantages and disadvantages of skin prick testing
Advantages:
1. Results within 15 minutes
2. More sensitive than RAST
3. High negative predictive value
4. Cost effective
Disadvantages:
1. High false positive rate
2. Results affected by use of corticosteroids or antihistamines
3. Risk of systemic reaction (though low)
4. Cannot perform if skin disease at testing site
Long-term complications of OSA
- RVH
- Pulmonary hypertension
- Systemic hypertension
- Cor pulmonale
- Polycythemia
- Cardiovascular disease in adulthood
Side effects of indomethacin
- Hypoglycemia
- Renal impairment
- Thrombocytopenia/bleeding risk
- Decreased cerebral blood flow
- NEC/GI perforation
- Hyponatremia
High risk criteria for ALL
- Age under 1 or over 10 years
- WBC > 50
- Minimal residual disease after induction therapy
- Unfavourable cytogenetics
- Testicular involvement
- CNS involvement
When to start antibiotics in a cat bite
- Deep wounds
- Bite on hand, face, feet or genitalia
- Signs of infection
- Immunocompromised
- Puncture wounds
Life-threatening complications of guillain barre
- Respiratory failure
- Aspiration pneumonia
- Cardiac arrhythmias
- Orthostatic hypotension
- Hypertension
- Paralytic ileus
Risk factors for severe hyperbilirubinemia
- Previous sibling with severe hyperbilirubinemia
- Cephalohematoma
- Severe bruising
- Jaundice under 24 hours
- Gestation less than 38 weeks
- Maternal age 25 years or older
- Dehydration
- Exclusive or partial breastfeeding
- Male sex
- Asian or European background
Causes of short gut syndrome
- Congenital short bowel syndrome
- Multiple atresias
- Gastroschisis
- Bowel resection - NEC, midgut volvulus, long-segment hirschprung’s, crohn’s, trauma
Posterior fossa brain tumours
- Glioma
- Ependymoma
- Medulloblastoma
- Astrocytoma
Risk factors for colon cancer in UC
- Family history of colon cancer
- > 8-10 years of disease
- Pancolitis
- Mucosal dysplasia
- Primary sclerosing cholangitis
Clinical manifestations of OSA
Nighttime symptoms: 1. Loud snoring 2. Breathing pauses 3. Gasping or choking arousals 4. Restless sleep 5. Nocturnal diaphoresis 6. More frequent and severe events when in supine position 7. Unusual sleeping positions Daytime symptoms: 1. Mouth breathing/dry mouth 2. Chronic nasal congestion/rhinorrhea 3. Morning headaches 4. Hyponasal speech 5. Difficulty swallowing 6. Poor appetite 7. Secondary enuresis
Indications for growth hormone
- GH deficiency
- Turner syndrome
- Prader willi
- End-stage renal failure before kidney transplant
- Idiopathic short stature with suboptimal growth velocirt
Complications of measles
- Diarrhea
- Encephalitis
- Otitis media
- Pneumonia
Mood/behaviour changes with OSA
- Daytime sleepiness or drowsiness, difficulty with morning wakening, unplanned napping
- Irritability, mood instability, emotional lability, depression/anxiety
- Somatic complaints
- Social withdrawal
- Aggression, oppositional behaviour
- Impulsivity, hyperactivity
- Executive function difficulties (cognitive flexibility, task initiation, self-monitoring, planning, organization)
Non-infectious causes of hepatitis
- Tyrosinemia
- Alpha-1-antitrypsin deficiency
- Autoimmune hepatitis
- Wilson’s disease
- Drug-induced hepatitis
Who gets RSV prophylaxis
- < 12 months with chronic lung disease requiring medical therapy
- < 12 months with hemodynamically significant congenital lung disease
- GA < 30 months and < 6 months of age without chronic lung disease
- GA < 36 months and < 6 months of age in remote communities
- Full term Inuit < 6 months of age in remote communities with high RSV admission rates
- Consider in < 24 months of age with: Trisomy 21, home oxygen, prolonged hospitalization for resp disease, or immunocompromised
PFT’s in asthma
- Decreased FEV1/FVC < 90% predicted
- Decreased FEV1 < 80% predicted
- Decreased FEF 25-75
- 12% improvement in FEV1 with bronchodilator