RBC Production, Function, and Morphology Flashcards
What can PSCs be stimulated by to create Pronormoblasts?
Colony Stimulating Factors (CSF)
Interleukins (IL)
Matures into 16 Erythrocytes
What stage of RBC does Hemoglobin start to synthesize?
Polychromatophilic Normoblast
Found in Bone Marrow
What is also known as an NRBC and is the final stage with a nucleus?
Orthochromic Normoblast
Found mostly in bone marrow; may migrate to blood
When do we see Effective Erythropoiesis?
In response to Anemic Stress
Evidence of regenerative marrow process
What does the Cytoskeleton make up?
The inner layer of the RBC membrane
Glycolipids and Glycoproteins make up what?
The outer layer of the RBC membrane
What does Cholesterol and Phospholipids make up?
The central layer of the RBC membrane
What are the Integral proteins responsible for active/passive transport and structure?
Glycophorin A, B, and C
What are the Peripheral proteins that are part of the Cytoskeleton and move through Arterioles?
Spectrin
Ankyrin
Name two of the processes used for metabolism of RBC’s
Embden Meyerhof Pathway
Methemoglobin Reductase Pathway
What is the formula and reference range for Mean Corpuscular Volume (MCV)?
Hematocrit/Red cell count x 10
80-100 fL
Macro/Micro
What is the formula and reference range for Mean Corpuscular Hemoglobin (MCH)?
Hemoglobin/Red blood cell count x 10
27-31 pg
What is the formula and reference range for Mean Corpuscular Hemoglobin Content (MCHC)?
Hemoglobin/Hemtaocrit x 100
32% - 36%
Hypo/Poly
When do we start to see Megaloblastic Anemia in patients?
MCV >110 fL
A patient has Pernicious Anemia, Liver disease, and Folic acid deficiency. What do we expect to see with their RBC’s?
Megaloblastic Anemia
When do we see Polychromatophilic RBC’s in patients?
In response to Anemic Stress
When do we see an elevated Reticulocyte count?
In rapid blood loss or high elevations
