Hemoglobin Function and Hemolysis

Question 1

What is heme?

Answer 1

Iron atom with a Protoporphyrin ring
Mitochondria and Cytoplasm

Question 2

What is Globin?

Answer 2

Polypeptide chain
Ribosomes

Question 3

How is a Heterodimer formed?

Answer 3

A-globin and a non A-globin

Question 4

When does Hemoglobin begin to synthesize?

Answer 4

Polychromatophilic Normoblast stage

Question 5

Which Hemoglobin is present for 3 months and 6 months prior to birth?

Answer 5

Embryonic Hgb

Question 6

Which Hemoglobin is present 6 months after birth and remains at low levels throughout life?

Answer 6

Fetal Hgb

Question 7

Which Hemoglobin is present throughout life?

Answer 7

Adult Hgb
Hgb A: 95% - 98%
Hgb A2: 3% - 5%
Hgb F: <2%

Question 8

What is the function of Hemoglobin?

Answer 8

Transport Oxygen
Bind to waste (2,3 DPG, Acid (H+))
Bicarbonate buffer system

Question 9

Is methemoglobin acquired or inherited?

Answer 9

Both
Acquired by Aniline/Anti-malarial
Inherited by amino acid substitution

Question 10

The Spleen, Liver, Bone Marrow, Lymph Nodes, and Monocytes are all what?

Answer 10

Places where Extravascular Hemolysis occurs

Question 11

Where do we see Hepatosplenomegaly?

Answer 11

Extravascular Lysis

Question 12

Where do we see Hemoglobinemia and Hemoglobinuria?

Answer 12

Intravascular Lysis

Question 13

Hemoglobinopathies, Red cell membrane defects, and Enzyme defects are examples of what?

Answer 13

Intrinsic Red Cell Defects