Hematopoiesis to CBC

Question 1

What is Hematopoiesis?

Answer 1

The production, development, differentiation, and maturation of all blood cells

Question 2

What is responsible for formation of RBC’s during the first 2 weeks to 2 months in the Mesoblastic Period?

Answer 2

The Yolk Sac

Question 3

What is the Liver and Spleen responsible for in the Hepatic Period?

Answer 3

Hematopoiesis during the 2 to 7 month Hepatic Period
WBC’s and MegaK

Question 4

What assumes the primary role in Hematopoiesis from 7 months through the rest of life?

Answer 4

Bone Marrow

Question 5

What fills in for the Bone Marrow in times of damage or luekemia?

Answer 5

Spleen
Thymus
Lymph Nodes

Question 6

Reservoir of platelets, RBC filtration, Phagocytic Activity, Hematopoietic Function are all examples of what?

Answer 6

Functions of the Spleen

Question 7

What is the major player in bone marrow?

Answer 7

Multipotential Pluripotent Stem Cells (PSC)

Question 8

What is the difference between Myeloid and Erythroid elements?

Answer 8

Myeloid - WBC
Erythroid - RBC

Question 9

What is the ratio of production between WBC and RBC?

Answer 9

3:1 to 4:1
6 - 10 hours for WBC

Question 10

What is the site of choice for bone marrow procedure?

Answer 10

Iliac Crest

Question 11

Why do we care about Spicules from specimen?

Answer 11

Spicules are richest with cells

Question 12

How many parameters exist for CBC?

Answer 12

9 total parameters
4 Directly measured
2 (In)directly measured
3 calculated

Question 13

What are the four Directly Measured parameters for CBC?

Answer 13

Red Blood Cell Count (RBC)
White Blood Cell Count (WBC)
Platelet Count (PLT)
Hemoglobin (Hgb)

Question 14

What are the two (In)Directly Measured parameters for CBC?

Answer 14

Hematocrit (Hct)
Mean Corpuscular Volume (MCV)
Depends on the instrument

Question 15

What are the three parameters that need to be calculated for CBC?

Answer 15

Mean Corpuscular Hemoglobin (MCH)
Mean Cell Hemoglobin Content (MCHC)
Red Blood Cell Distribution Width (RDW)

Question 16

What are the values from newborn to adult male and female for RBC?

Answer 16

Newborn: 4.0 - 6.0
Male: 4.7 - 6.1
Female: 4.2 - 5.4

Question 17

What are the values from newborn to adult male and female for Hgb?

Answer 17

Newborn: 17 - 23
Male: 14 - 18
Female: 12 - 16

Question 18

What are the values from newborn to adult male and female for HCT?

Answer 18

Newborn: 53 - 65
Male: 42 - 52
Female: 37 - 47

Question 19

What are the formulas for Hgb and Hct in relation to the Rule of Three?

Answer 19

RBC x 3 = Hgb
Hgb x 3 = Hct +- 3