RBC Pathologies

Question 1

What are the pathologies assoc w/ Acanthocyte (spur cell)?

Answer 1

• Liver dz
• Abetalipoproteinemia (state of cholesterol dysregulation)

Question 2

What are the pathologies assoc w/ Basophilic stippling?

Answer 2

• Thalassemias
• Anemia of chronic dz
• Lead poisoning

Question 3

What are the pathologies assoc w/ Bite cell?

Answer 3

G6PD deficiency

Question 4

What are the pathologies assoc w/ Elliptocyte?

Answer 4

Hereditary elliptocytosis

Question 5

What are the pathologies assoc w/ Macro-ovalocyte?

Answer 5

• Megaloblastic anemia (also hyperseg PMNs)
• Marrow failure

Question 6

Which pathologies are assoc w/ Ringed sideroblasts?

Answer 6

Sideroblastic anemia

Excess iron in mitochondria

Question 7

Which pathologies are assoc w/ Schistocyte, helmet cell?

Answer 7

• DIC
• TTP/HUS
• Traumatic hemolysis (metal heart valve)

Question 8

Which pathologies are assoc w/ Sickle cell?

Answer 8

Sickle cell anemia

Question 9

Which pathologies are assoc w/ Spherocyte?

Answer 9

• Hereditary spherocytosis
• Autoimmune hemolysis

Question 10

Which pathologies are assoc w/ Teardrop cell?

Answer 10

Bone marrow infiltration

Question 11

How are Heniz bodies formed?

Answer 11

Oxidation of iron from ferrous to ferric form l/t denatured Hb precipitation & damage to RBC mem→ formation of bite cells

Question 12

Which pathologies are assoc w/ Heinz bodies?

Answer 12

• G6PD def
• Heinz body-like inclusions see in alpha-thalassemia

Question 13

What are Howell-Jolly bodies?

Answer 13

Basophilic nuclear remnants found in RBCs

Question 14

What removes Howell-Jolly bodies?

Answer 14

Removed from RBC’s by splenic macrophages

Question 15

Which pathologies are Howell-Jolly bodies assoc w/?

Answer 15

• Functional hyposplenia
• Asplenia
• After mothball ingestion (naphalene)