RBC intro

Question 1

name the metabolic pathways RBC use for energy and the enzymes involved

Answer 1

Embden Meyerhof PathwayAnaerobic glucose metabolismCreates ATP for cellular functionKEY ENZYME -> PYRUVATE KINASE

Hexose Monophosphate ShuntPrevents oxidative stress through conversion of H2O2 into H2OKEY ENZYME -> GLUCOSE-6-PHOSPHATE DEHYDROGENASE (G6PD)

Methhaemoglobin Reductase PathwayMaintains Iron in ferrous state (Fe2+) to facilitate oxygen transportKEY ENZYME -> METHAEMOGLOBIN REDUCATSE

Question 2

disorders of RBC

Answer 2

Haemoglobinopathies

Membranopathies

Enzymopathies

Question 3

genes affected in hemoglobinopathies and what does this result in

Answer 3

• An abnormal haemoglobin protein (variant)- A reduction in synthesis of that globin chain (thalassaemia)- A combination of the two