chronic myeloid leukemia Flashcards
1
Q
define
A
mature cell lineage
malignancy of granulocyte cells (WBC)
2
Q
what cells does it affect?
A
neutrophils
basophils
eosinophils
macrophages
3
Q
commonly found in? age?
A
> 40yrs
4
Q
presentation
A
- loss of weight, fever, sweats, fatigue
- gout (purine infections)
- bleeding
- abdominal poin bc of splenic enlargement
- anaemia - breath;essness, fatigue, pallor
- infection
- massive hapatosplenomegaly
5
Q
treatment
A
- baseline quantities PCR BCR:ABL1
- start imatinib 400mg daily
- monitor FBC for haematological remission
- reassess spleen size every 3 months
- monitor BCR:ABL1 every 3 months
6
Q
Philadelphia Chromosome (Ph+)
A
translocation between chromosome 9 and chromosome 22
leading to BCR-ABL1 fusion
causes constant activation of tyrosine kinase activity
