RBC INCLUSION BODIES Flashcards

CONTENT, OTHER NAMES, DISEASE ASSOCIATION

1
Q

made up of AGGREGATED RNA

A

BASOPHILIC STIPPLINGS

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2
Q

form of basophilic stippling observed when there is INCREASED POLYCHROMATOPHILIA

A

FINE STIPPLING

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3
Q

form of basophilic stippling which may be observed in PLUMBISM or other disorders with IMPAIRED Hb H SYNTHESIS, in MEGALOBLASTIC ANEMIA, and in other forms of severe anemia

A

COARSE STIPPLING

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4
Q

made up of ERYTHROCYTIC COLLECTIONS OF IRON

A

SIDEROTIC GRANULES

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5
Q

described as multiple DARK BLUE irregular granules in PRUSSIAN BLUE IRON STAINING

A

SIDEROTIC GRANULES

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6
Q

described as PALE BLUE clusters in WRIGHT STAINING

A

PAPPENHEIMER BODIES

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7
Q

stain used to exhibit SIDEROTIC GRANULES

A

IRON STAIN: PERLS’ REAGENT THROUGH PRUSSIAN BLUE RXN

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8
Q

stains used to exhibit PAPPENHEIMER BODIES

A
  1. NEW METHYLENE BLUE
  2. WRIGHT STAIN

“naa siyay NEW PEN para mag WRIGHT (write)”

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9
Q

frequently appears SINGLY in a cell (only one per cell), usually round, and <1 um in diameter, blue to purple in color

A

HOWELL-JOLLY BODIES

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10
Q

composed of REMNANTS OF NUCLEAR CHROMATIN (DNA)

A

HOWELL-JOLLY BODIES

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11
Q

made up of MITOTIC SPINDLE REMNANTS

A

CABOT RINGS

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12
Q

described as threadlike structures that appear as PURPLE-BLUE LOOPS (FIGURE OF 8 APPEARANCE)

A

CABOT RINGS

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13
Q

most of the time APPEAR ECCENTRICALLY along the INNER RBC MEMBRANE, large, round, blue to purple materials

A

HEINZ BODIES

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14
Q

made up of DENATURED AND PRECIPITATED HEMOGLOBIN

A

HEINZ BODIES

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15
Q

described as small, multiple, EVENLY DISTRIBUTED THROUGHOUT THE RED CELL, granular, greenish-blue bodies

A

Hb H INCLUSION BODIES

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16
Q

made up of precipitated Hb H

A

Hb H INCLUSION BODIES

17
Q

DISEASE ASSOC:

associated with LEAD POISONING, PYRIMIDINE-5’-NUCLEOTIDASE DEFICIENCY, THALASSEMIA, MEGALOBLASTIC ANEMIA, ALCOHOLISM, REFRACTORY ANEMIA

A

BASOPHILIC STIPPLING

18
Q

DISEASE ASSOC:

associated with SIDEROBLASTIC ANEMIA, THALASSEMIA, HEMOCHROMATOSIS or HEMOSIDEROSIS

A

SIDEROTIC GRANULES

19
Q

DSE ASSOC:

associated with MEGALOBLASTIC ANEMIA, AFTER SPLENECTOMY, THALASSEMIA

A

HOWELL-JOLLY BODIES

20
Q

DISEASE ASSOC:

associated with MEGALOBLASTIC ANEMIA, REFRACTORY ANEMIA, LEAD POISIONING

A

CABOT RINGS

21
Q

DSE ASSOC:

associated with G6PD DEFICIENCY, DIHA, UNSTABLE Hb DSE

A

HEINZ BODIES

22
Q

DISEASE ASSOC:

associated with Hb H DISEASE

A

Hb H INCLUSION BODIES

23
Q

other name for BASOPHILIC STIPPLING

A

PUNCTATE BASOPHILIA

24
Q

SIDEROTIC GRANULES are aka

A

PAPPENHEIMER BODIES

25
Q

inclusions in MEGALOBLASTIC ANEMIA

only according to the table for inclusion bodies, not sa anemia descrip

A
  1. BASOPHILIC STIPPLING
  2. HOWELL-JOLLY BODIES
  3. CABOT RINGS
26
Q

inclusions in THALASSEMIA

only according to the table for inclusion bodies, not sa dse descrip

A
  1. DACRYOCTE
  2. BASOPHILIC STIPPLING
  3. SIDEROTIC GRANULES/PAPPENHEIMER BODIES
  4. HOWELL-JOLLY BODIES
27
Q

positive for FEULGEN REACTION

A

HOWELL-JOLLY BODIES

28
Q

4 supravital stains to demonstrate HEINZ BODIES

A
  1. BRILLIANT CRESYL BLUE
  2. NEW METHYLENE BLUE
  3. METHYL VIOLET
  4. CRYSTAL VIOLET
29
Q

what is the appearance of RBCs with Hb H Bodies?

A

PITTED GOLF BALL