ERYTHROCYTES Flashcards
What test is RARELY DONE because of its inaccuracy and questionable necessity?
RBC COUNT
RBC METABOLIC PATHWAYS:
NON-OXIDATIVE, ANAEROBIC PATHWAY
EMBDEN-MEYERHOF PATHWAY
RBC METABOLIC PATHWAYS:
Glucose penetrates the red blood cell with NO ENERGY EXPENDITURE via what transmembrane protein?
GLUT-1
RBC METABOLIC PATHWAYS:
What pathway handles 90% OF GLUCOSE UTILIZATION in RBCs?
EMBDEN-MEYERHOF PATHWAY
How many molecules of ATP does the EMP produce?
2 MOLECULES OF ATP
MOST COMMON ENZYME DEFICIENCY IN THE EMP
PYRUVATE KINASE DEFICIENCY
MOST COMMON form of HEREDITARY NONSPHEROCYTIC HEMOLYTIC ANEMIA (HNSHA)
PYRUVATE KINASE DEFICIENCY
What kind of disorder is PK deficiency?
AUTOSOMAL RECESSIVE (AR)
possible PBS findings in PK deficiency include what cells?
ACANTHOCYTES, BURR CELL
“siya daw mag P(a)Y sa CAN sa EMPe”
PYRUVATE KINASE, ACANTHOCYTES, EMP
RECOMMENDED SCREENING TEST for PK deficiency
PK FLUORESCENT SPOT TEST
CONFIRMATORY TEST for PK deficiency
QUANTITATIVE PK TEST
what shunt is also known as the Pentose Phosphate Pathway or Phosphogluconate Pathway?
HEXOSE MONOPHOSPHATE SHUNT
HMP is also known as?
- PENTOSE PHOSPHATE PATHWAY
- PHOSPHOGLUCONATE PATHWAY
AEROBICALLY converts GLUCOSE to PENTOSE
HEXOSE MONOPHOSPHATE SHUNT
end-product of HMP
NADPH (Nicotinamide Adenine Dinucleotide Phosphate (reduced))
NADPH reduces what substance?
GLUTATHIONE
pathway that PREVENTS the DENATURATION of GLOBIN BY OXIDATION
HEXOSE MONOPHOSPHATE SHUNT
MOST COMMON ENZYME DEFICIENCY in the Pentose Phosphate Pathway
G6PD DEFICIENCY
MOST COMMON RBC ENZYME DEFECT
G6PD DEFICIENCY
what kind of disorder is G6PD?
X-LINKED RECESSIVE (XLR)
possible PBS findings for G6PD DEFICIENCY
- HEINZ BODIES
- BITE CELLS
RECOMMENDED SCREENING test for G6PD DEFICIENCY
G6PD FLUORESCENT SPOT TEST
CONFIRMATORY TEST for G6PD DEFICIENCY
QUANTITATIVE G6PD ASSAY
what class of G6PD is FAVISM or FAVA BEANS associated with?
CLASS II
Class II variants of G6PD where Favism is related to
- G6PD-MEDITERRANEAN
- G6PD-CHATHAM
mostly related with G6PD-MEDITERRANEAN ang FAVISM :)
pathway that MAINTAINS IRON IN THE HEME in its REDUCED STATE
METHEMOGLOBIN REDUCTASE PATHWAY
Methemoglobin Reductase Pathway is also known as
CYTOCHROME B5 REDUCTASE
Pathway for the PRODUCTION OF 2,3-DPG
RAPOPORT-LUEBERING PATHWAY
what binds to the Hb and DECREASES THE O2 AFFINITY OF Hb?
2,3-DPG
a shift in the curve due to an ALTERATION IN pH
BOHR EFFECT
depicts the occurrence by which the binding of O2 to the hemoglobin promotes the release of CO2
HALDANE EFFECT
SHIFT TO RIGHT OR LEFT:
INCREASED AFFINITY
SHIFT TO THE LEFT
kapit jud teh para di ka ma “left” behind 🤩
DECREASED AFFINITY
SHIFT TO THE RIGHT
let go na because it’s the “right” thing to do 😞
INCREASED pH
SHIFT TO THE LEFT
shape of the curve in Oxygen Dissociation Curve
SIGMOIDAL
