ERYTHROCYTES

Question 1

What test is RARELY DONE because of its inaccuracy and questionable necessity?

Answer 1

RBC COUNT

Question 2

RBC METABOLIC PATHWAYS:

NON-OXIDATIVE, ANAEROBIC PATHWAY

Answer 2

EMBDEN-MEYERHOF PATHWAY

Question 3

RBC METABOLIC PATHWAYS:

Glucose penetrates the red blood cell with NO ENERGY EXPENDITURE via what transmembrane protein?

Answer 3

GLUT-1

Question 4

RBC METABOLIC PATHWAYS:

What pathway handles 90% OF GLUCOSE UTILIZATION in RBCs?

Answer 4

EMBDEN-MEYERHOF PATHWAY

Question 5

How many molecules of ATP does the EMP produce?

Answer 5

2 MOLECULES OF ATP

Question 6

MOST COMMON ENZYME DEFICIENCY IN THE EMP

Answer 6

PYRUVATE KINASE DEFICIENCY

Question 7

MOST COMMON form of HEREDITARY NONSPHEROCYTIC HEMOLYTIC ANEMIA (HNSHA)

Answer 7

PYRUVATE KINASE DEFICIENCY

Question 8

What kind of disorder is PK deficiency?

Answer 8

AUTOSOMAL RECESSIVE (AR)

Question 9

possible PBS findings in PK deficiency include what cells?

Answer 9

ACANTHOCYTES, BURR CELL

“siya daw mag P(a)Y sa CAN sa EMPe”

PYRUVATE KINASE, ACANTHOCYTES, EMP

Question 10

RECOMMENDED SCREENING TEST for PK deficiency

Answer 10

PK FLUORESCENT SPOT TEST

Question 11

CONFIRMATORY TEST for PK deficiency

Answer 11

QUANTITATIVE PK TEST

Question 12

what shunt is also known as the Pentose Phosphate Pathway or Phosphogluconate Pathway?

Answer 12

HEXOSE MONOPHOSPHATE SHUNT

Question 13

HMP is also known as?

Answer 13

1. PENTOSE PHOSPHATE PATHWAY
2. PHOSPHOGLUCONATE PATHWAY

Question 14

AEROBICALLY converts GLUCOSE to PENTOSE

Answer 14

HEXOSE MONOPHOSPHATE SHUNT

Question 15

end-product of HMP

Answer 15

NADPH (Nicotinamide Adenine Dinucleotide Phosphate (reduced))

Question 16

NADPH reduces what substance?

Answer 16

GLUTATHIONE

Question 17

pathway that PREVENTS the DENATURATION of GLOBIN BY OXIDATION

Answer 17

HEXOSE MONOPHOSPHATE SHUNT

Question 18

MOST COMMON ENZYME DEFICIENCY in the Pentose Phosphate Pathway

Answer 18

G6PD DEFICIENCY

Question 19

MOST COMMON RBC ENZYME DEFECT

Answer 19

G6PD DEFICIENCY

Question 20

what kind of disorder is G6PD?

Answer 20

X-LINKED RECESSIVE (XLR)

Question 21

possible PBS findings for G6PD DEFICIENCY

Answer 21

1. HEINZ BODIES
2. BITE CELLS

Question 22

RECOMMENDED SCREENING test for G6PD DEFICIENCY

Answer 22

G6PD FLUORESCENT SPOT TEST

Question 23

CONFIRMATORY TEST for G6PD DEFICIENCY

Answer 23

QUANTITATIVE G6PD ASSAY

Question 24

what class of G6PD is FAVISM or FAVA BEANS associated with?

Answer 24

CLASS II

Question 25

Class II variants of G6PD where Favism is related to

Answer 25

1. G6PD-MEDITERRANEAN
2. G6PD-CHATHAM

mostly related with G6PD-MEDITERRANEAN ang FAVISM :)

Question 26

pathway that MAINTAINS IRON IN THE HEME in its REDUCED STATE

Answer 26

METHEMOGLOBIN REDUCTASE PATHWAY

Question 27

Methemoglobin Reductase Pathway is also known as

Answer 27

CYTOCHROME B5 REDUCTASE

Question 28

Pathway for the PRODUCTION OF 2,3-DPG

Answer 28

RAPOPORT-LUEBERING PATHWAY

Question 29

what binds to the Hb and DECREASES THE O2 AFFINITY OF Hb?

Answer 29

2,3-DPG

Question 30

a shift in the curve due to an ALTERATION IN pH

Answer 30

BOHR EFFECT

Question 31

depicts the occurrence by which the binding of O2 to the hemoglobin promotes the release of CO2

Answer 31

HALDANE EFFECT

Question 32

SHIFT TO RIGHT OR LEFT:

INCREASED AFFINITY

Answer 32

SHIFT TO THE LEFT

kapit jud teh para di ka ma “left” behind 🤩

Question 33

DECREASED AFFINITY

Answer 33

SHIFT TO THE RIGHT

let go na because it’s the “right” thing to do 😞

Question 34

INCREASED pH

Answer 34

SHIFT TO THE LEFT

Question 35

shape of the curve in Oxygen Dissociation Curve

Answer 35

SIGMOIDAL