RBC anomalies Flashcards
refers to erythrocytes with normal
amount of hemoglobin.
normochromic cell
refers to erythrocytes wherein the
central light area of the cell is larger and paler than the
normal
hypochromic cell
red cells which have an increased
hb content and wherein the central light area is
smaller than the normal
hyperchromic
his condition wherein the red cell are stained with
various shades of blue with tinges of pink.
Polychromatophilia or Polychromasia or Diffuse
Basophilia
Condition where in the
red cells appear pale
hypochromasia
2 possible causes of hypochromasia
Dec hb concentration
* Abnormal thinness of the
cells:
* IDA
* Sideroblastic anemia
* thalassemia
Conditioned wherein the
red cell are deeply
stained to abnormal
thickness of cells.
hyperchromasia
condition where in the red
cells vary in size both macrocytes and
microcytes coexist on the same smear.
Anisocytosis
larger than normal greater than
8 um in size round in shape mcv > 100 FL
Macrocyte
cell which is less than 6 um in size
MCV less than 80 fl
Microcyte
Abnormal cytoplasmic maturation but normal
nuclear maturation
defect of microcyte
large oval-shaped red cell which is 9-12
um
megalocyte
Abnormal nuclear maturation but normal
cytoplasmic maturation
defect of megalocyte
red cells exhibit variation in shape
Poikilocytosis
normal cell with a biconcave disc
shape with increased surface volume surface
discocyte
small dense
RBC with few irregularly
spaced projections of varying
length
acanthocyte
- Cell membrane is
folded - Cell assumes a “
Pocket book roll”
appearance or biscuit
shape
BISCUIT CELL ( FOLDED RBC)
cell with irregularly
spaced blunt processes,
resembles crenated RBC
burr cell or echinocyte
cell w/ eccentric
vacuoles due to the
plucked out Heinz body
blister cell or bite cell
ATP deficiency
due to prolonged
storage of
anticoagulated blood
- sea urchin cell
ECHINOCYTES OR CRENATED CELLS
Target cell/ Mexican Hat
/cells with bull’s eye
appearance
CODOCYTES
Def. in cholesterol,
phospholipid in the membrane
Def in Lecithin cholesterol acyl
transferase ( LCAT)
CODOCYTES
- abnormal
maturation squeezing
and fragmentation
during splenic passage - Cells appear in the
shape of a pear with a single short
or long protrusion.
TEARDROP CELL (DACRYOCYTE)
- Hb appears to be
concentrated at the two
ends of the cell leaving a
normal central area of pallor - can be found in healthy person
ELLIPTOCYTES or ovalo cyte
small round dense cell
which lacks the central
pallor area usually
microcytic and sphere
shaped.
Spherocyte
Cresent shape cell due to
abnormal aggregation of HbS
which gives a tendency for the
cell to assume a _____
SICKLE CELLS ( DREPANOCYTES)
Cell fragmentation
due to trauma caused by
physical and mechanical
agents.
SCHISTOCYTES or schizocyte
Characterized by an
elongated or slit-like area of
central pallor
stomatocyte or mouth cell
SS : Dark blue granules and
filaments in cytoplasm
WS : Bluish tinge throughout
cytoplasm
Diffuse Basophilia
SS : Dark blue-purple, fine or
coarse punctate granules
distributed throughout
cytoplasm
WS : Same with SS
basophilic stippling
SS : Dark blue-purple dense,
round granule; usually
one per cell; occasionally
multiple
WS : Same with SS
howell-jolly body
SS : Round, dark blue-purple
granule attached to inner
RBC membrane
WS : not visible
heinz body
SS : Irregular clusters of small,
light to dark blue granules
often near periphery of the
cell
WS : same w SS
PAPPENHEIMER BODIES
SS : Rings or figure-eights
* WS : Blue rings or figure-
eights
CABOT RING
SS :Fine, evenly dispersed,
dark blue granules;
imparts“golf ball”
appearance to RBCs
* WS : not visible
Hemoglobin H inclusion
MISCELLANEOUS VARIATIONS
- Rouleaux formation – stacks of coins
- Partially hemolyzed RBC=
- Acid stain of erythrocytes- red cell is colored RED
- Alkaline stain of erythrocytes – if buffer soln is too
alkaline , red cell are colored dirty gray - Design Formation of RBC – caused by fat or oil on the
slide ahead of the spreader during the smear
preparation
