RBC anomalies Flashcards

1
Q

refers to erythrocytes with normal
amount of hemoglobin.

A

normochromic cell

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2
Q

refers to erythrocytes wherein the
central light area of the cell is larger and paler than the
normal

A

hypochromic cell

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3
Q

red cells which have an increased
hb content and wherein the central light area is
smaller than the normal

A

hyperchromic

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4
Q

his condition wherein the red cell are stained with
various shades of blue with tinges of pink.

A

Polychromatophilia or Polychromasia or Diffuse
Basophilia

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5
Q

Condition where in the
red cells appear pale

A

hypochromasia

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6
Q

2 possible causes of hypochromasia

A

Dec hb concentration
* Abnormal thinness of the
cells:
* IDA
* Sideroblastic anemia
* thalassemia

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7
Q

Conditioned wherein the
red cell are deeply
stained to abnormal
thickness of cells.

A

hyperchromasia

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8
Q

condition where in the red
cells vary in size both macrocytes and
microcytes coexist on the same smear.

A

Anisocytosis

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9
Q

larger than normal greater than
8 um in size round in shape mcv > 100 FL

A

Macrocyte

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10
Q

cell which is less than 6 um in size
MCV less than 80 fl

A

Microcyte

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11
Q

Abnormal cytoplasmic maturation but normal
nuclear maturation

A

defect of microcyte

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12
Q

large oval-shaped red cell which is 9-12
um

A

megalocyte

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13
Q

Abnormal nuclear maturation but normal
cytoplasmic maturation

A

defect of megalocyte

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14
Q

red cells exhibit variation in shape

A

Poikilocytosis

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15
Q

normal cell with a biconcave disc
shape with increased surface volume surface

A

discocyte

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16
Q

small dense
RBC with few irregularly
spaced projections of varying
length

A

acanthocyte

17
Q
  • Cell membrane is
    folded
  • Cell assumes a “
    Pocket book roll”
    appearance or biscuit
    shape
A

BISCUIT CELL ( FOLDED RBC)

18
Q

cell with irregularly
spaced blunt processes,
resembles crenated RBC

A

burr cell or echinocyte

19
Q

cell w/ eccentric
vacuoles due to the
plucked out Heinz body

A

blister cell or bite cell

20
Q

ATP deficiency
due to prolonged
storage of
anticoagulated blood

  • sea urchin cell
A

ECHINOCYTES OR CRENATED CELLS

21
Q

Target cell/ Mexican Hat
/cells with bull’s eye
appearance

22
Q

Def. in cholesterol,
phospholipid in the membrane
Def in Lecithin cholesterol acyl
transferase ( LCAT)

23
Q
  • abnormal
    maturation squeezing
    and fragmentation
    during splenic passage
  • Cells appear in the
    shape of a pear with a single short
    or long protrusion.
A

TEARDROP CELL (DACRYOCYTE)

24
Q
  • Hb appears to be
    concentrated at the two
    ends of the cell leaving a
    normal central area of pallor
  • can be found in healthy person
A

ELLIPTOCYTES or ovalo cyte

25
small round dense cell which lacks the central pallor area usually microcytic and sphere shaped.
Spherocyte
26
Cresent shape cell due to abnormal aggregation of HbS which gives a tendency for the cell to assume a _____
SICKLE CELLS ( DREPANOCYTES)
27
Cell fragmentation due to trauma caused by physical and mechanical agents.
SCHISTOCYTES or schizocyte
28
Characterized by an elongated or slit-like area of central pallor
stomatocyte or mouth cell
29
SS : Dark blue granules and filaments in cytoplasm WS : Bluish tinge throughout cytoplasm
Diffuse Basophilia
30
SS : Dark blue-purple, fine or coarse punctate granules distributed throughout cytoplasm WS : Same with SS
basophilic stippling
31
SS : Dark blue-purple dense, round granule; usually one per cell; occasionally multiple WS : Same with SS
howell-jolly body
32
SS : Round, dark blue-purple granule attached to inner RBC membrane WS : not visible
heinz body
33
SS : Irregular clusters of small, light to dark blue granules often near periphery of the cell WS : same w SS
PAPPENHEIMER BODIES
34
SS : Rings or figure-eights * WS : Blue rings or figure- eights
CABOT RING
35
SS :Fine, evenly dispersed, dark blue granules; imparts“golf ball” appearance to RBCs * WS : not visible
Hemoglobin H inclusion
36
MISCELLANEOUS VARIATIONS
1. Rouleaux formation – stacks of coins 2. Partially hemolyzed RBC= 3. Acid stain of erythrocytes- red cell is colored RED 4. Alkaline stain of erythrocytes – if buffer soln is too alkaline , red cell are colored dirty gray 5. Design Formation of RBC – caused by fat or oil on the slide ahead of the spreader during the smear preparation