RBC anomalies

Question 1

refers to erythrocytes with normal
amount of hemoglobin.

Answer 1

normochromic cell

Question 2

refers to erythrocytes wherein the
central light area of the cell is larger and paler than the
normal

Answer 2

hypochromic cell

Question 3

red cells which have an increased
hb content and wherein the central light area is
smaller than the normal

Answer 3

hyperchromic

Question 4

his condition wherein the red cell are stained with
various shades of blue with tinges of pink.

Answer 4

Polychromatophilia or Polychromasia or Diffuse
Basophilia

Question 5

Condition where in the
red cells appear pale

Answer 5

hypochromasia

Question 6

2 possible causes of hypochromasia

Answer 6

Dec hb concentration
* Abnormal thinness of the
cells:
* IDA
* Sideroblastic anemia
* thalassemia

Question 7

Conditioned wherein the
red cell are deeply
stained to abnormal
thickness of cells.

Answer 7

hyperchromasia

Question 8

condition where in the red
cells vary in size both macrocytes and
microcytes coexist on the same smear.

Answer 8

Anisocytosis

Question 9

larger than normal greater than
8 um in size round in shape mcv > 100 FL

Answer 9

Macrocyte

Question 10

cell which is less than 6 um in size
MCV less than 80 fl

Answer 10

Microcyte

Question 11

Abnormal cytoplasmic maturation but normal
nuclear maturation

Answer 11

defect of microcyte

Question 12

large oval-shaped red cell which is 9-12
um

Answer 12

megalocyte

Question 13

Abnormal nuclear maturation but normal
cytoplasmic maturation

Answer 13

defect of megalocyte

Question 14

red cells exhibit variation in shape

Answer 14

Poikilocytosis

Question 15

normal cell with a biconcave disc
shape with increased surface volume surface

Answer 15

discocyte

Question 16

small dense
RBC with few irregularly
spaced projections of varying
length

Answer 16

acanthocyte

Question 17

• Cell membrane is
  folded
• Cell assumes a “
  Pocket book roll”
  appearance or biscuit
  shape

Answer 17

BISCUIT CELL ( FOLDED RBC)

Question 18

cell with irregularly
spaced blunt processes,
resembles crenated RBC

Answer 18

burr cell or echinocyte

Question 19

cell w/ eccentric
vacuoles due to the
plucked out Heinz body

Answer 19

blister cell or bite cell

Question 20

ATP deficiency
due to prolonged
storage of
anticoagulated blood

• sea urchin cell

Answer 20

ECHINOCYTES OR CRENATED CELLS

Question 21

Target cell/ Mexican Hat
/cells with bull’s eye
appearance

Answer 21

CODOCYTES

Question 22

Def. in cholesterol,
phospholipid in the membrane
Def in Lecithin cholesterol acyl
transferase ( LCAT)

Answer 22

CODOCYTES

Question 23

• abnormal
  maturation squeezing
  and fragmentation
  during splenic passage
• Cells appear in the
  shape of a pear with a single short
  or long protrusion.

Answer 23

TEARDROP CELL (DACRYOCYTE)

Question 24

• Hb appears to be
  concentrated at the two
  ends of the cell leaving a
  normal central area of pallor
• can be found in healthy person

Answer 24

ELLIPTOCYTES or ovalo cyte

Question 25

small round dense cell which lacks the central pallor area usually microcytic and sphere shaped.

Answer 25

Spherocyte

Question 26

Cresent shape cell due to abnormal aggregation of HbS which gives a tendency for the cell to assume a _____

Answer 26

SICKLE CELLS ( DREPANOCYTES)

Question 27

Cell fragmentation due to trauma caused by physical and mechanical agents.

Answer 27

SCHISTOCYTES or schizocyte

Question 28

Characterized by an elongated or slit-like area of central pallor

Answer 28

stomatocyte or mouth cell

Question 29

SS : Dark blue granules and filaments in cytoplasm WS : Bluish tinge throughout cytoplasm

Answer 29

Diffuse Basophilia

Question 30

SS : Dark blue-purple, fine or coarse punctate granules distributed throughout cytoplasm WS : Same with SS

Answer 30

basophilic stippling

Question 31

SS : Dark blue-purple dense, round granule; usually one per cell; occasionally multiple WS : Same with SS

Answer 31

howell-jolly body

Question 32

SS : Round, dark blue-purple granule attached to inner RBC membrane WS : not visible

Answer 32

heinz body

Question 33

SS : Irregular clusters of small, light to dark blue granules often near periphery of the cell WS : same w SS

Answer 33

PAPPENHEIMER BODIES

Question 34

SS : Rings or figure-eights * WS : Blue rings or figure- eights

Answer 34

CABOT RING

Question 35

SS :Fine, evenly dispersed, dark blue granules; imparts“golf ball” appearance to RBCs * WS : not visible

Answer 35

Hemoglobin H inclusion

Question 36

MISCELLANEOUS VARIATIONS

Answer 36

1. Rouleaux formation – stacks of coins 2. Partially hemolyzed RBC= 3. Acid stain of erythrocytes- red cell is colored RED 4. Alkaline stain of erythrocytes – if buffer soln is too alkaline , red cell are colored dirty gray 5. Design Formation of RBC – caused by fat or oil on the slide ahead of the spreader during the smear preparation