hemoglobin

Question 1

iron bearing protein contained
within the erythrocytes

Answer 1

hemoglobin

Question 2

one gram of hemoglobin can carry

Answer 2

1.34 ml of oxygen

Question 3

FUNCTIONS OF
HEMOGLOBIN

Answer 3

Transport oxygen from the lungs
to the tissue and carbon dioxide
from the tissue
- acid- base balance regulation

Question 4

1 heme is equal to

Answer 4

1 moles of oxygen

Question 5

1 hemoglobin is equal to

Answer 5

4 moles of oxygen

Question 6

young erythroblast is synthesized from

Answer 6

polychromatophilic normoblast stage up to reticulocytes stage

Question 7

Structure of Heme/composition of heme

Answer 7

• Protophorphyrin IX
• Ferrous iron

Question 8

Each globin consists of what?

Answer 8

8 helices separated by 7 non helices segments

Question 9

2nd helix of amino acid

Answer 9

amino acid sequence

Question 10

Secondary helix

Answer 10

helices and non
helices

Question 11

Tertiary helix

Answer 11

pretzel like
configuration

Question 12

quaternary helix

Answer 12

complete molecule

Question 13

ability of hemoglobin to bind or
release oxygen . Expressed in terms of the oxygen
tension at which hgb is 50% saturated

Answer 13

oxygen affinity

Question 14

oxygen tension also known as partial pressure

Answer 14

partial pressure of oxygen

Question 15

relationship of O2 affinity with
Hb to pH

Answer 15

bohr effect

Question 16

Inc Hb affinity for O2

Answer 16

increased pH (alkalosis)

Question 17

dec hb affinity for O2

Answer 17

decreased pH (acidosis)

Question 18

the normal position of curve depends on

Answer 18

§ Concentration of 2,3-DPG
§ H+ ion concentration (pH)
§ CO2 in red blood cells
§ Structure of Hb

Question 19

Right shift (decreases oxygen affinity , more 02 release to the
tissues

Answer 19

§ High 2,3-DPG
§ Dec body pH
§ High CO2
§ HbS

Question 20

hemoglobin in combination with
oxygen.
gives pinkness to the skin and mucous membrane.
seen in arterial circulation

Answer 20

Oxyhemoglobin

Question 21

hgb with iron but no O2 seen in
venous circulation
unassociated with oxygen.

Answer 21

Deoxyhemoglobin

Question 22

Found in normal human embryos
and fetuses with a gestational age
of less than three months

Answer 22

Embryonic Hemoglobin

Question 23

Composed of 2 zeta and 2 epsilon globin
chains

Answer 23

Hemoglobin Gower I

Question 24

Composed of 2 alpha and 2 epsilon

Answer 24

Hemoglobin Gower 2

Question 25

composed of 2 zeta and 2 gamma

Answer 25

Hemoglobin Portland

Question 26

Composed 0f 2 alpha and 2 gamma

Answer 26

Fetal Hemoglobin

Question 27

normal adult hemoglobin

Answer 27

hemoglobin A or A1

Question 28

the major hemoglobin of the fetus and newborns

Answer 28

fetal hemoglobin

Question 29

Constitutes less than 3% of the total hemoglobin

Answer 29

hemoglobin A2

Question 30

degradation product of HbA2

Answer 30

hemoglobin A3

Question 31

this is the primary hemoglobin in people with sickle cell disease

Answer 31

hemoglobin S

Question 32

replaced by valine in the 6th position of beta chain

Answer 32

Glutamic acid

Question 33

one of the most common beta chain hemoglobin variants in the world

Answer 33

hemoglobin E

Question 34

an abnormal hemoglobin that occurs in some cases of alpha thalassemia

Answer 34

hemoglobin hct

Question 35

Has a brownish to bluish color and does not revert to red on exposure to oxygen.

Answer 35

methemoglobin

Question 36

Formed by the irreversible oxidation of Hb of certain drugs and chemicals.

Answer 36

sulfhemoglobin

Question 37

examples of sulfhemoglobin

Answer 37

a. sulfonomides b. phenacetin c. acetanilide

Question 38

silent killer for its colorless gas , odor and patient becomes easily hypoxic

Answer 38

CARBOXYHEMOGLOBIN

Question 39

qualitative screening test based on specific gravity. The density of the drop of blood is directly proportional to the amount of hemoglobin it contains.

Answer 39

Copper Sulfate Specific Gravity

Question 40

principle of Copper Sulfate Specific Gravity

Answer 40

when the drop of donor's blood dropped into copper sulfate solution becomes encased in a sac of copper proteinate

Question 41

ref range for male

Answer 41

3.5-18 g/dL

Question 42

ref range for femle

Answer 42

2-15 g/dL

Question 43

NTERFERING FACTORS

Answer 43

Hb is normally dec during pregnancy People living at high altitudes have increased Hb values, as well as inc. Hct and RBC. * Excessive fluid intake cause a decreased Hb. * Normally , the Hb is higher in infants * Drugs