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Physiology > Rbc > Flashcards

Rbc Flashcards

1
Q

Describe the stages of development of erythrocyte from PHSC

A
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2
Q

Describe the stages of development from CFU-E to erythrocyte

A
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3
Q

Clincal importance of reticulocytopenia and reticulocytosis

A
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4
Q

What are the general factors affecting erythropoiesis

A

Tissue oxygenation
Hormone
Hemopoietic growth factors
Metals

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5
Q

Which are the hormone responsible for erythropoiesis

A

Erythropoietin
Androgen
Estrogen
Catecholamines
ACTH& adrenocorticoids

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6
Q

In which stages of erythropoiesis do the hormone erythropoietin take in action

A

Erythropoietin stimulate the production of pronormoblast from hematopoietic stem cell

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7
Q

Site of secretion of erythropoietin

A
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8
Q

Based on the site erythropoiesis can be classify as

A
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9
Q

What is erythropoiesis

A

Origin ,development ,and maturation the entire process of RBC

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10
Q

Which is the smallest nucleated precursor in erythropoiesis

A

Orthochromatic erythroblast /late normoblast

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11
Q

Which is the most essential regulatory in erythropoiesis

A

Tissue oxygenation

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12
Q

Site of production of erythropoietin which is the major

A

Kidney(85%)peritubular capillaries
Liver (15%)perivenous hepatocytes
Brain

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13
Q

Major functions of erythropoietin

A

Differentiation of pronormoblast to mature RBC
Inc Hb synth
Dec maturation time of RBC
Stimulate release of mature erythrocytes from bone marrow

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14
Q

Which are the haemopoeitic growth factors

A

IL-3 (T cell)
Stem cell factor
GM-CSF
Burst promoting factors

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15
Q

VIT B12 complex taken up by _

A

Cubilin

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16
Q

Specify about the chemical nature of erythropoietin

A

Glycoprotein
165 amino acid and 4 oligo saccharide

17
Q

Which factor help in determine the blood sugar level for a long term

A

Glycated Hb
HbA1c

18
Q

Main site of destruction of RBC

A

Reticulo endothelial system
Spleen
Liver
Bone marrow

19
Q

A colour of biliverdin B colour of bilirubin A

A

A:green
B:yellow

20
Q

Which component give colour to faeces

A

Stercobilin

21
Q

Morphological classification of anemia

A

Microcytic hypochromic
Normocytic normochromic
Macrocyctic

22
Q

Normal bilirubin concentration

A

0.2-0.8 mg/100ml

23
Q

Write down the speciality of Hb which is use full for the glucose level of prolonged period

A

Glycated Hb HbA1C
Glucose is attached to the beta chain of Hb A
Rate of production of HbA1C is directly prop to glucose concern

24
Q

What are the three fate of urobilin

A

Strecobilinogen
Entering hepatic circulation
General circulation

Physiology (11 decks)

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