Rbc Flashcards
Describe the stages of development of erythrocyte from PHSC
Describe the stages of development from CFU-E to erythrocyte
Clincal importance of reticulocytopenia and reticulocytosis
What are the general factors affecting erythropoiesis
Tissue oxygenation
Hormone
Hemopoietic growth factors
Metals
Which are the hormone responsible for erythropoiesis
Erythropoietin
Androgen
Estrogen
Catecholamines
ACTH& adrenocorticoids
In which stages of erythropoiesis do the hormone erythropoietin take in action
Erythropoietin stimulate the production of pronormoblast from hematopoietic stem cell
Site of secretion of erythropoietin
Based on the site erythropoiesis can be classify as
What is erythropoiesis
Origin ,development ,and maturation the entire process of RBC
Which is the smallest nucleated precursor in erythropoiesis
Orthochromatic erythroblast /late normoblast
Which is the most essential regulatory in erythropoiesis
Tissue oxygenation
Site of production of erythropoietin which is the major
Kidney(85%)peritubular capillaries
Liver (15%)perivenous hepatocytes
Brain
Major functions of erythropoietin
Differentiation of pronormoblast to mature RBC
Inc Hb synth
Dec maturation time of RBC
Stimulate release of mature erythrocytes from bone marrow
Which are the haemopoeitic growth factors
IL-3 (T cell)
Stem cell factor
GM-CSF
Burst promoting factors
VIT B12 complex taken up by _
Cubilin
Specify about the chemical nature of erythropoietin
Glycoprotein
165 amino acid and 4 oligo saccharide
Which factor help in determine the blood sugar level for a long term
Glycated Hb
HbA1c
Main site of destruction of RBC
Reticulo endothelial system
Spleen
Liver
Bone marrow
A colour of biliverdin B colour of bilirubin A
A:green
B:yellow
Which component give colour to faeces
Stercobilin
Morphological classification of anemia
Microcytic hypochromic
Normocytic normochromic
Macrocyctic
Normal bilirubin concentration
0.2-0.8 mg/100ml
Write down the speciality of Hb which is use full for the glucose level of prolonged period
Glycated Hb HbA1C
Glucose is attached to the beta chain of Hb A
Rate of production of HbA1C is directly prop to glucose concern
What are the three fate of urobilin
Strecobilinogen
Entering hepatic circulation
General circulation
