Rb and Cancer

Question 1

What did research on DNA tumour viruses lead to the discovery of?

Answer 1

Tumour suppressor genes

Question 2

Who discovered the first DNA tumour viruses in the 1930s?

Answer 2

Richard Shope

Question 3

What is retinoblastoma?

Answer 3

A rare, childhood cancer of the eye

Question 4

What are the two forms of retinoblastoma and what percentage of cases does each type account for?

Answer 4

Familial accounts for 40%

Sporadic accounts for 60%

Question 5

Which chromosomal location do patients with retinoblastoma have visible alterations of?

Answer 5

Chromosome 13

Particularly band 13q14.1

Question 6

Deletions of the same region of chromosome 13 are detected in tumour cells from patients with the sporadic form of retinoblastoma, true or false?

Answer 6

True

Question 7

What family is Rb a member of?

Answer 7

The pocket protein family

Question 8

What is the role of INK?

Answer 8

Regulates G1 to S phase transition

Question 9

What is the role of ARF?

Answer 9

Regulates the tumour suppressor p53