Rats Flashcards
Color of rats that is most common in research
Albino
Second most common rats found in research
hooded
Like mice, rats are active at night so they are reffered to as
nocturnal
Rats enjoy _____ and building nests
burrowing
A rat will escape from their cage, but
they will always return to it
A good source of enrichment and also helps prevent malocclusions of teeth
Wooden blocks
A rat tail’s 2 functions:
- Thermoregulation
2. Balance
Their tails are as long as __% of their bodies
85
These can be confused with the salivary glands or lymph nodes, but it is where glycogen is stored to provide 10x more energy
Brown fat
2 parts of a rat’s stomach
- glandular
2. aglandular
This doesn’t allow a rat to vomit
limiting ridge
Rats lack a _______ in their abdomen
gallbladder
This structure of the rat’s GI tract is highly developed and has rumen-like functions
cecum
Mammary tumors in rats are usually
benign
Large pigmented horseshoe-shaped lacrimal glands behind the eye that secrete tears with high concentrations of porphyrin
Harderian glands
How many mammary glands do rats have?
6 PAIRS (12 total)
The predominate WBCs in rats
lymphocytes
Male rats have higher ___________ and ___________ counts than females
granulocytes, lymphocytes
Rats have produce highly concentrated urine, so the ___________ are elevated and cages should be cleaned frequently to avoid respiratory illness or renal and liver failure
ammonia
A rat’s diet should contain __-__% protein and _% fat
20-25%, 4%
This type of diet is preferred over seed mixtures
pelleted
Rats tend to become ______ when fed ad lib
obese
These are good to give as snacks to pet rats occasionally
fruit, veggies, or seeds
To recycle Vitamin B, rats perform
coprophagy
Average life span of a rat
2.5-3 yrs
Normal Temp of a rat
99.5-100.6
Normal HR of a rat
250-450 BPM
Normal RR of a rat
70-115 RPMS
Average gestation of a rat
21-23 days
Average litter size of rats
6-12 pups
Housing temperature for rats should be kept at
18-26 CELSIUS
Rats should have _ hrs of light and __ hrs of dark
12:12
Average humidity the environment should be at
30-70%
Average number of air exchanges
10-15/hr
Ecological classes are similar to
mice
Ecological class typically used in research
Specific pathogen free
For an inbred strain, they should be bred for __ generations
20
Inbred strain that spontaneously develop diabetes
BB
Inbred strain that develop diabetes insipidus
Brattleboro
Mutant strain that lack a thymus, therefore lack T cells and B cells can’t be activated
Need special sterile environments
Nude
These mutant strain rats naturally become overweight and spontaneously develop type 2 diabetes
ZDF
ZDF
Zucker Diabetic Fatty Rat
These mutant strain of rats lack an entire acquired immune system and are used in immune system studies
Need special housing
SCID
SCID
Severe Compromised Immunodeficiency Dz rats
Best way to sex a rat
anogenital distance
Have a longer anogenital distance
Males
Female rats’ estrus cycle is
polyestrous
This effect is less pronounced in rats
Whitten
This effect does not affect rats
Bruce
This effect does happen with rats
Lee Boot
Postpartum estrous starts
48 hrs after birth
Average weaning age of rats
19-23 days
This is common in female and male rats to reduce the effect of infant mortality due to males eating the babies
Polygamy
You should not pick rats up by their
tails
Most common site for venipuncture
Tail vein
No more than this much blood should be drawn every 2-3 weeks
10-15%
Total blood volume =
0.07 x wt. in grams
Medications are usually given most often
in water or feed
For a SQ injection, you should use this size needle
23-25 g
This type of injection should only be given when absolutely necessary because it is painful
IM
IP injections should be given in the
lower, right side abdominal quadrants
This is not required before anesthesia because rats have a high metabolism and can’t vomit
Fasting
Drug combo used for anesthesia
Ketamine/xylazine
When under anesthesia, rats _____ should be kept lubricated
eyes
Max dose for an IP injection
2.0 mL/100g
Max dose for a SQ injection
2.0 mL/100g
Max dose for an IM injection
0.3/site /mL/100g
Max dose for an IV injection
0.5 mL/100g
Max dose for PO
2.0mL/100g
PO dosing should not exceed
5mLs
3 main analgesics used for rats
- Butorphanol
- Buprenephrine
- Metacam
Caused by 3 serovars
Highly contagious
Wide range of symptoms (tremors, jaundice, ataxia, stunted growth, and oily coats)however, adult rats can be asymptomatic
Virus is shed in bodily fluids
Parvovirus
Causes sialodacryoadentitis
C/S: swelling of lymph nodes and bulging eyes from the swelling of harderian glands
Coronavirus
Rats recover from sialodacryoadentitis in about
1 week
Caused by the parainfluenza virus type 1
Dz depends on the host’s immune status
C/S: respiratory signs, weight loss, chattering
Sendai Virus
Most common dz in rats
C/S: respiratory and genital infx
Highly contagious
Mycoplasmosis
These are common in rats and are large but rarely metastasize
Mammary tumors
Parasites seen in rats
Pinworms and mites
Causes constriction of the tail and happens when there is less than 20% humidity in their environment
Ring tail
Overgrown incisors that can be fixed with nail clippers
Malocclusions
Incisors are open-rooted or AKA
hypsodontic
In a clinical setting, pet rats are euthanized with
Overdose of KCl
In a research setting, rats are euthanized with
Overdose of CO2