Rate Limiting Enzymes

Question 1

Glycolysis (2/2)

Answer 1

Phosphofructokinase

Pos: AMP, Fructose-2,6-biphosphate
Neg: ATP, citrate

Question 2

Gluconeogenesis (2/2)

Answer 2

Fructose-1,6-bisphosphonate

Pos: ATP, acetyl-CoA
Neg: AMP, fructose-2,6-bisphosphonate

Question 3

TCA Cycle (1/2)

Answer 3

Isocitrate dehydrogenase

Pos: ADP
Neg: ATP, NADH

Question 4

Glycogenesis (3/2)

Answer 4

Glycogen synthase

Pos: Glucose-6-phosphate, insulin, cortisol
Neg: Epi, glucagon

Question 5

HMP shunt (1/1)

Answer 5

Glucose-6-phosphate dehydrogenase (G6PD)

Pos: NADP+
Neg: NADPH

Question 6

De novo pyrimidine synthesis

Answer 6

Carbomyl phosphate synthetase II

Question 7

De novo purine synthesis (0/3)

Answer 7

Gutamine-phosphoribosylpyrophosphate (PRPP) amidotransferase

Neg: AMP, IMP, GMP

Question 8

Urea Cycle (1/0)

Answer 8

Carbamoyl phosphate synthetase I

Pos: N-acetylglutamate

Question 9

Fatty acid synthesis (2/2)

Answer 9

Acetyl-CoA carboxylase (ACC)

Pos: Insulin, citrate
Neg: Glucagon, palmitoyl-CoA

Question 10

Ketogenesis

Answer 10

HMG-CoA synthase

Question 11

Cholesterol synthesis (2/2)

Answer 11

HMG-CoA reductase

Pos: Insulin, Thyroxine
Neg: Glucagon, Cholesterol