RatBB_Chp29_Immunology

Question 1

model of respiratory track allergies

Answer 1

Brown Norway

Question 2

autoimmune disease models

Answer 2

Brown Norway and Lewis

Question 3

CD45

Answer 3

B Cell

Question 4

CD4

Answer 4

Helper T cell, TH1 or TH2 based on cytokine production

Question 5

CD8

Answer 5

Cytotoxic T cell

Question 6

• Natural killer cells

Answer 6

large granular lymphoctyes with MHC mediated cytotoxicity but can also help with antibody dependent cell mediated cytotoxicity (somewhere between adaptive and innate immunity)

Question 7

MHC (major histocompatibility complex)

Answer 7

• Chromosome 20 (like mice)

* Self/ non self-discrimination by immune system

Question 8

Cytokines:

Answer 8

pleiotropic molecules that mediate biological effects through transmission of stimulatory and inhibitory signals

Question 9

Th1 Cytokines

Answer 9

IL2 and INFy

Question 10

Th2 Cytokines

Answer 10

IL4, IL10, IL13

Question 11

• BBDP (diabetes prone biobreeding rat):

Answer 11

discovered in outbred Wistar colony, develop spontaneous diabetes and thyroiditis between 60-120 days of age

Question 12

• LEC (Long Evans Cinnamon):

Answer 12

don’t develop CD4 T cells

Question 13

• BN (Brown Norway):

Answer 13

CD4 T cells often TH2 immune response, high IgE responders

Question 14

• LEW (Lewis):

Answer 14

TH1 mediated autoimmune disease