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AG_Rats > Rat Strains > Flashcards

Rat Strains Flashcards

1
Q

ACI (A C Irish)

A

congenital genitourinary abnormalities, prostatic adenocarcinomas
agouti w white belly/feet

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2
Q

BB/Wor (outbred Wistar at Biobreeding Labs):

A

juvenile insulin dependent diabetes mellitus (Type 1)
BBDP=diabetes prone
BBDR=resistant (control)
albino

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3
Q

BN (Brown Norway):

A

inducible, transplantable myeloid leukemia; hydronephrosis; bladder carcinoma; allergy studies
autoimmune dz model

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4
Q

BUF (Buffalo):

A

spontaneous autoimmune thyroiditis, host for transplantable Morris hepatoma; endocrine tumors

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5
Q

COP (Copenhagen, white w a brown hood):

A

prostate adenocarcinoma; resist estrogen induced mammary tumors

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6
Q

F-344 (Fischer 344):

A

inbred rat model for National Toxicology Program’s Carcinogen Bioassay Program and the National Institute on Aging; high incidence of interstitial cell tumor and LGL leukemia
albino

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7
Q

LEW (Lewis):

A

multiple sclerosis and rheumatoid arthritis, various experimentally induced autoimmune diseases
albino

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8
Q

LOU/C (Louvain):

A

Myeloma, production of IgG autoantibody

albino

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9
Q

SHR (spontaneous hypertensive rat):

A

hypertension, cardiovascular research; derived from WKY (used as control)
albino

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10
Q

WF (Wistar-Furth):

A

mononuclear cell leukemia

albino

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11
Q

Zucker Diabetic Fatty, ZDF

A

obesity
Neuropathy, wound healing, periodontal dz
Carries fa/fa mutation for leptin receptor
Males and females fed different diets to induce diabetes

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12
Q

Brattleboro (DI):

A

diabetes insipidus (autosomal recessive)
absence of vasopressin
white w black hood

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13
Q

Gunn

A

Jaundice, kernicterus (a recessive), hyperbilirubinemic model of Crigler Najjar (Ugt1a1 mutation)
elevated unconjugated bilirubin
Lacks the enzyme uridine diphosphate glucuronyltransferase (UDPGT)
single gene - hydronephrosis
albino

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14
Q

Obese SHR:

A

Type 4 hyperlipoproteinemia (a recessive)

albino

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15
Q

Outbred:

A

Sprague Dawley, Wistar (original lab rat), Long Evans (hooded, has fewer mammary tumors and resistant to infectious disease)

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16
Q

Wistar Kyoto (WKY):

A

control for SHR, inbred from Wistar

17
Q

Dahl salt sensitive (SS):

A

hypertensions, obese hyperlipidemic hyperinsulemic

18
Q

Long Evans Cinnamon (LEC):

A

icterus, hyper bilirubinemic model of Wilson’s disease

19
Q

RNU

A

Foxn1rnu, athymic T cell deficient (Chr 10)
• Hairless (rnunz, New Zealand) and cyclic hair growth varieties
• Congenital hypoplasia of the thymus
• Females fertile, but poor development of mammary glands so best to breed hets

20
Q

zucker obese, zucker fatty

A 
obese
Recessive mutation (fa) of the leptin-receptor protein (Chr5)
does not dev Type 2 DM
21
Q

FHH

Fawn-hooded Hypertensive

A

White with fawn hood
Hypertension
Hereditary bleeding disorder (platelet storage pool deficiency)

22
Q

RCS

Royal College of Surgeons

A 
Pink-eyed, tan-hooded
Retinal degeneration (carries gene for retinal dystrophy)
Model of human retitinitis pigmentosa
23
Q

Dahl Hypertensive-Sensitive (SS/Jr)

A

albino
Hypertension
Control=SR/Jr
High salt diet induces hypertension sooner

24
Q

SHROB

Spontaneously Hypertensive Obese Rat…Koletsky Rat

A

albino
Obesity
Spontaneous hypertension
Absence of leptin receptor

25
Q

DIO

Dietary-Induced Obesity Prone

A

albino
Obese (hypertension when obese)
High fat, sucrose, carb diet
Develops significant obesity with normal leptin levels (others are leptin/ leptin receptor deficient)

26
Q

NBL

Noble rat

A

white w black hood

Prostate carcinoma

27
Q

Eisai Hyperbilirubinuria Rat

A

Dubin-Johnson syndrome (hereditary conjugated hyperbilirubinemia)
Autosomal recessive

28
Q

Beige

DA-bg/bg= dark agouti

A

Chediak-Higashi syndrome

↓NK cell and neutrophil chemotaxis

29
Q

Spotting Lethal Mutant Rat

A 
Congenital aganglionosis (Hirschprung’s)
Also known as Piebald (Ednrb)
30
Q

DA

Dark Agouti

A

EAE (myelin basic protein and IFA)
Rheumatoid arthritis (induce with IFA/type II collagen)
AUTOIMMUNE DZ

31
Q

SHHF

Spontaneous Hypertensive Heart Failure

A

Obesity
Type 2 diabetes
CHF

32
Q

SHRSP

SHR-Stroke Prone

A

Cerebral hemorrhage/infarction

M>F

33
Q

Han:SPRD

Han:Sprague-Dawley (Cy/+)

A

Autosomal Dominant polycystic kidney dz (ADPKD)…Bright’s DZ

34
Q

LW

Lobund-Wistar

A

Prostate adenocarcinoma

35
Q

GAERS

Genetic Absence Epilepsy Rat from Strasbourg

A

Absence Epilepsy

36
Q

WAG/Rij

Wistar Albino Glaxo

A

Absence epilepsy
Retinal degeneration
Retinitis pigmentosa

37
Q

GEPR

Genetically Epilepsy-Prone

A

Epilepsy (sound stimulus)
GEPR/3-15 days of age
GEPR/9-21 days of age

38
Q

Cohen Diabetic

A

Non-obese model of diabetes
Normotensive
Cohen-Rosenthal=hypertensive variant

AG_Rats (5 decks)

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