Rat Strains Flashcards by Anna Goodroe

ACI (A C Irish)

congenital genitourinary abnormalities, prostatic adenocarcinomas
agouti w white belly/feet

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BB/Wor (outbred Wistar at Biobreeding Labs):

juvenile insulin dependent diabetes mellitus (Type 1)
BBDP=diabetes prone
BBDR=resistant (control)
albino

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BN (Brown Norway):

inducible, transplantable myeloid leukemia; hydronephrosis; bladder carcinoma; allergy studies
autoimmune dz model

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BUF (Buffalo):

spontaneous autoimmune thyroiditis, host for transplantable Morris hepatoma; endocrine tumors

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COP (Copenhagen, white w a brown hood):

prostate adenocarcinoma; resist estrogen induced mammary tumors

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F-344 (Fischer 344):

inbred rat model for National Toxicology Program’s Carcinogen Bioassay Program and the National Institute on Aging; high incidence of interstitial cell tumor and LGL leukemia
albino

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LEW (Lewis):

multiple sclerosis and rheumatoid arthritis, various experimentally induced autoimmune diseases
albino

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LOU/C (Louvain):

Myeloma, production of IgG autoantibody

albino

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SHR (spontaneous hypertensive rat):

hypertension, cardiovascular research; derived from WKY (used as control)
albino

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WF (Wistar-Furth):

mononuclear cell leukemia

albino

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Zucker Diabetic Fatty, ZDF

obesity
Neuropathy, wound healing, periodontal dz
Carries fa/fa mutation for leptin receptor
Males and females fed different diets to induce diabetes

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Brattleboro (DI):

diabetes insipidus (autosomal recessive)
absence of vasopressin
white w black hood

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Gunn

Jaundice, kernicterus (a recessive), hyperbilirubinemic model of Crigler Najjar (Ugt1a1 mutation)
elevated unconjugated bilirubin
Lacks the enzyme uridine diphosphate glucuronyltransferase (UDPGT)
single gene - hydronephrosis
albino

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Obese SHR:

Type 4 hyperlipoproteinemia (a recessive)

albino

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Outbred:

Sprague Dawley, Wistar (original lab rat), Long Evans (hooded, has fewer mammary tumors and resistant to infectious disease)

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Wistar Kyoto (WKY):

control for SHR, inbred from Wistar

Dahl salt sensitive (SS):

hypertensions, obese hyperlipidemic hyperinsulemic

Long Evans Cinnamon (LEC):

icterus, hyper bilirubinemic model of Wilson’s disease

RNU

Foxn1rnu, athymic T cell deficient (Chr 10)
• Hairless (rnunz, New Zealand) and cyclic hair growth varieties
• Congenital hypoplasia of the thymus
• Females fertile, but poor development of mammary glands so best to breed hets

zucker obese, zucker fatty

obese
Recessive mutation (fa) of the leptin-receptor protein (Chr5)
does not dev Type 2 DM

FHH

Fawn-hooded Hypertensive

White with fawn hood
Hypertension
Hereditary bleeding disorder (platelet storage pool deficiency)

RCS

Royal College of Surgeons

Pink-eyed, tan-hooded
Retinal degeneration (carries gene for retinal dystrophy)
Model of human retitinitis pigmentosa

Dahl Hypertensive-Sensitive (SS/Jr)

albino
Hypertension
Control=SR/Jr
High salt diet induces hypertension sooner

SHROB

Spontaneously Hypertensive Obese Rat…Koletsky Rat

albino
Obesity
Spontaneous hypertension
Absence of leptin receptor

DIO | Dietary-Induced Obesity Prone

albino Obese (hypertension when obese) High fat, sucrose, carb diet Develops significant obesity with normal leptin levels (others are leptin/ leptin receptor deficient)

NBL | Noble rat

white w black hood | Prostate carcinoma

Eisai Hyperbilirubinuria Rat

Dubin-Johnson syndrome (hereditary conjugated hyperbilirubinemia) Autosomal recessive

Beige | DA-bg/bg= dark agouti

Chediak-Higashi syndrome | ↓NK cell and neutrophil chemotaxis

Spotting Lethal Mutant Rat

``` Congenital aganglionosis (Hirschprung’s) Also known as Piebald (Ednrb) ```

DA | Dark Agouti

EAE (myelin basic protein and IFA) Rheumatoid arthritis (induce with IFA/type II collagen) AUTOIMMUNE DZ

SHHF | Spontaneous Hypertensive Heart Failure

Obesity Type 2 diabetes CHF

SHRSP | SHR-Stroke Prone

Cerebral hemorrhage/infarction | M>F

Han:SPRD | Han:Sprague-Dawley (Cy/+)

Autosomal Dominant polycystic kidney dz (ADPKD)…Bright’s DZ

LW | Lobund-Wistar

Prostate adenocarcinoma

GAERS | Genetic Absence Epilepsy Rat from Strasbourg

Absence Epilepsy

WAG/Rij | Wistar Albino Glaxo

Absence epilepsy Retinal degeneration Retinitis pigmentosa

GEPR | Genetically Epilepsy-Prone

Epilepsy (sound stimulus) GEPR/3-15 days of age GEPR/9-21 days of age

Cohen Diabetic

Non-obese model of diabetes Normotensive Cohen-Rosenthal=hypertensive variant