A&A_Rats Flashcards
• Use of volatile anesthetics requires BSC that is
HARD DUCTED (Class II, Type B2) for scavenging purposes
• Charcoal filtration does not remove
nitrous oxide from anesthetic circuit
• Blood: gas partition coefficient of volatile anesthetic determines
rapidity of induction, how quick you can alter depth of anesthesia, and how rapidly animal recovers
o Lower = more rapid; lung alveolar concentration of gas reaches levels similar to inspired gas very quickly and then it jumps into blood stream
o Sevoflurane is lower
• Altricial rodents are
poikilotherms
isoflurane
neuroprotective, protective in ischemic cardiac disease (smaller infarcts), minimally metabolized by liver, may impair gut motility
• Ket/ alpha 2
hyperglycemia
• 2,2,2 tribromoethanol: Avertin
o minimum cardiodepressive effects
o rapid induction, recovery with good muscle relaxation
o not controlled
o Drawbacks:
• Must be reconstituted, breaks down if exposed to light, no pharmaceutical grade available
• Adverse reactions to toxic by products such as dibromoacetladehyde
• Fibrinous adhesions, inflammation within peritoneal cavity
• Dissolve only in tertiary amyl alcohol and filter prior to use
• Neuroleptanalgesic combinations
opioid analgesic and tranquilizer combinations
Neuromuscular Blocking Agents
• D-tubocurarine, galalamine, succinylcholine, 4-aminopyridine
• Chloral hydrate
o Adynamic ileus in rats, 5-16 days post IP injection
o Extravascular irritant
• Ether: gas
o Requires storage in explosion-proof fridge and off gassing of animal carcass in a fume hood to allow volatile peroxides to dissipate prior to carcass disposal
o Respiratory irritant
• Urethane: ethyl carbamate
o Long anesthesia with preservation of autonomic reflexes
o Carcinogenic
• Alpha chloralose:
administered IV then transformed into trichloroethanol, little analgesia
o Only recommended for non recovery procedures
o Minimal depression resp/ cardiac reflexes
• Inactin:
thiobutabarbital sodium salt hydrate
