rapid review COPY Flashcards
abdominal pain
ascities
hepatomegaly
budd chiari syndrome
post hepatic venous thrombosis
abdominal pain
diarrhea
leukocytosis (WBCs up)
recent abx
c diff infection
achilles tendon xanthoma
familial hypercholesterolemia
decrease LDL receptor signalling
adrenal hemorrhage
hypotension
DIC
waterhouse friderichsen syndrome
meningococcemia
anaphylaxis following blood transfusion
IgA def
anterior “drawer sign” positive
ACL injury
arachnodactyly
lens dislocation upward
aortic dissection
hyperflexible joints
marfans syndrome
fibrillin defect
athlete with polycythemia
secondary to erythropoietin injection
back pain
fever
night sweats
potts disease
vertebral TB
bilateral acoustic scwannomas
neurofibromatosis type 2
bilateral hilar adenopathy
uveitis
sarcoidosis
noncaseating granulomas
black eschar on face of patient with DKA
mucor or rhizopus fungal infection
blue sclera
osteogenesis imperfecta
type 1 collagen defect
bluish line on gingiva
burton line
lead poisoning
bone pain
bone enlargement
arthritis
paget disease of bone
increased OB and OC activity
bounding pulses
wide pulse pressure
diastolic heart murmur
head bobbing
aortic regurg
“butterfly” facial rash
raynaud phenomenon
young female
SLE
cafe au lait spots lisch nodules (iris hamartoma) cutaneous neurofibromas pheochromocytoma optic gliomas
neurofibromatosis type 1
cafe au lait spots (unilateral)
polyostotic fibrous dysplasia
precocious puberty
multiple endocrine abnormalities
McCune Albright syndrome
mosaic G protein signaling mutation
calf pseudohypertrophy
muscular dystrophy
most commonly duchenne
due to x linked recessive frameshift mutation of dystrophin gene
cervical LAD desquamating rash coronary aneurysms red conjunctiva and tongue hand foot changes
kawasaki disease
treat with IVIG and aspirin
“cherry red spots” on macula
Tay sachs (ganglioside accumulation)
or
niemann pick (sphingomyelin accumulation)
due to central retinal artery occlusion
chest pain on exertion
angina
stable= with moderate exertion
unstable= with minimal exertion or at rest
chest pain
pericardial effusion/friction rub
persistent fever following MI
dressler syndrome
autoimmune mediated post MI fibrinous pericarditis
2 weeks to several months after an acute episode
chest pain with ST depressions on EKG
unstable angina (negative troponins)
or
NSTEMI (positive troponins)
child uses arms to stand up from a squat
duchenne muscular dystrophy
gowers sign
child with fever later develops a red rash on his face that spreads to his body
erythema infectiosum/fifth disease
“slapped cheeks” appearance
caused by parvovirus B19
chorea
dementia
caudate degeneration
huntington disease
autosomal dominant CAG repeat expansion
chorioretinitis
hydrocephalus
intracranial calcifications
congenital toxoplasmosis
chronic exercise intolerance myalgia fatigue painful cramps myoglobinuria
McArdle disease
skeletal muscle glycogen phosphorylase deficiency
cold intolerance
hypothyroidism
conjugate horizontal gaze palsy
horizontal diplopia
internuclear ophthalmoplegia
due to damage to the MLF
may be unilateral or bilateral
continuous “machine like” heart murmur
PDA
close with indomethacin
keep open with PGE analogs
cutaneous/dermal edema due to connective tissue deposition
myxedema
caused by:
hypothyroidism
graves disease ([pretibial])
cutaneous flushing
diarrhea
bronchospasm
carcinoid syndrome
right sided cardiac valvular lesions
increased 5-HIAA
dark purple skin/mouth nodules in a patient with AIDS
kaposi sarcoma
associated with HHV8
deep, labored breathing/hyperventilating
DKA
kussmaul respirations
dermatitis
dementia
diarrhea
pellagra
niacin deficiency (vit B3)
dilated cardiomyopathy
edema
alcoholism or malnutrition
wet beriberi
```
thiamine deficiency
vit B1
~~~
dog or cat bite resulting in infection
pasteurella multocida
cellulitis at the inoculation site
dry eyes
dry mouth
arthritis
Sjogren syndrome
autoimmune destruction of exocrine glands
dysphagia (esophageal webs)
glossitis
iron def anemia
Plummer Vinson syndrome
may progress to esophageal squamous cell carcinoma
elastic skin
hypermobility of joints
increased bleeding tendency
ehlers danlos syndrome
type 5 collagen defect
type 3 collagen defect seen in the vascular subtype of ehlers danlos
enlarged, hard left supraclavicular node
virchow node
abdominal metastasis
episodic vertigo
tinnitus
hearing loss
meniere disease
the inner ear disorder
erythroderma
LAD
hepatosplenomegaly
atypical T cells
mycosis fungoides
(cutaneous T cell lymphoma)
or
sezary syndrome
(mycosis fungoides + malignant T cells in blood)
facial muscle spasm upon tapping
chvostek sign
hypocalcemia
fat
female
forty
fertile
cholelithiasis
aka gallstones
fever
chills
headache
myalgia following abx treatment for syphilis
Jarisch Herxheimer reaction
rapid lysis of spirochetes results in endotoxin like release
fever cough conjunctivitis coryza (nose mucosa inflamm) diffuse rash
measles
fever
night sweats
weight loss
B symptoms of lymphoma
Fibrous plaques in soft tissue of penis with abnormal curvature
peyronic disease
connective tissue disorder
Golden brown rings around peripheral cornea
Wilson disease
kayser fleischer rings due to copper accumulation
Gout
intellectual disability
self mutilating behavior in a boy
Lesch nyhan syndrome
HGPRT deficiency
x linked recessive
hamartomatous GI polyps
hyperpigmentation of the mouth/feet/hands/genitalia
peutz jeghers syndrome
inherited
benign polyposis
can cause bowel obstruction
increased cancer risk
mainly GI
hepatosplenomegaly pancytopenia osteoporosis aseptic necrosis of femoral head bone crises
Gaucher disease
glycocerebrosidase deficiency
hereditary nephritis
sensorineural hearing loss
cataracts
Alport syndrome
mutation in collagen 4
hyperphagia
hypersexuality
hyperorality
hyperdocility (agreeable and submissive)
Kluver Bucy syndrome
bilateral amygdala lesions
hyperreflexia
hypertonia
babinski sign present
UMN damage
hyporeflexia
hypotonia
atrophy
fasciculations
LMN damage
hypoxemia (low O2 in blood)
polycythemia (hct high)
hypercapnia (CO2 high)
chronic bronchitis
hyperplasia of mucous cells
“blue bloater”
Indurated, ulcerated genital lesion
painful with exudate= chancroid
(haemophilus ducreyi)
non painful= chancre
(primary syphilis, treponema pallidum)
infant with cleft lip/palate
microcephaly or holoprosencephaly
polydactyly
cutis aplasia
Patau syndrome
trisomy 13
infant with hypoglycemia
hepatomegaly
cori disease (debranching enzyme deficiency)
or
von gierke disease
(glucose 6 phosphatase deficiency, more severe)
infant with microcephaly
rocker bottom feet
clenched hands
structural heart defect
Edwards syndrome
trisomy 18
jaundice
palpable distended non tender gallbladder
courvoisier sign
distal malignant obstruction of the biliary tree
large rash with bull’s eye appearance
erythema chronicum migrans from ixodes tick bite
lyme disease= borrelia
lucid (clear) interval after traumatic brain injury
epidural hematoma
middle meningeal artery rupture
male child
recurrent infections
no mature B cells
bruton disease
x linked agammaglobulinemia
mucosal bleeding
prolonged bleeding time
glanzmann thrombasthenia
defect in platelet aggregation due to lack of Gp2b/3a
muffled heart sounds
distended neck veins
hypotension
Beck triad of cardiac tamponade
multiple colon polyps
osteomas/soft tissue tumors
impacted/super-numerary teeth
Gardner syndrome
a subtype of FAP
myopathy
(infantile hypertrophic cardiomyopathy)
exercise intolerance
pompe disease
lysosomal alpha 1,4 glucosidase deficiency
neonate with arm paralysis following difficult birth
erb-duchenne palsy
superior trunk (C5-C6) brachial plexus injury
“waiter’s tip”
No lactation postpartum
absent menstruation
cold intolerance
sheehan syndrome
pituitary infarction
nystagmus
intention tremor
scanning speech
bilateral internuclear ophthalmoplegia
multiple sclerosis
painful blue fingers/toes
hemolytic anemia
cold agglutination disease
autoimmune hemolytic anemia caused by:
mycoplasma pneumoniae
infectious mononucleosis
CLL
painful fingers/toes changing color from white to blue to red with cold or stress
raynaud phenomenon
vasospasm in extremities
painful raised red lesions on pads of fingers/toes
osler nodes
infective endocarditis
immune complex deposition
painless erythematous lesions on the palms and soles
Janeway lesions
infective endocarditis
septic emboli
microabscesses
painless jaundice
cancer of the pancreatic head obstructing bile duct
palpable purpura on buttocks/legs
joint pain
abdominal pain (child)
hematuria
henoch schonlein purpura
IgA vasculitis affecting skin and kidneys
pancreatic tumor
pituitary tumor
parathyroid tumor
MEN1
autosomal dominant
periorbital and/or peripheral edema
proteinuria (>3.5g/day)
hypoalbuminemia
hypercholesterolemia
nephrotic syndrome
pink complexion
dyspnea
hyperventilation
emphysema
“pink puffer”
centriacinar (smoking) or panacinar (alpha1 antitrypsin deficiency)
polyuria renal tubular acidosis type 2 growth failure electrolyte imbalances hypophosphatemic rickets
fanconi syndrome
multiple combined dysfunction of the proximal convoluted tubule
pruritic (itchy), purple, polygonal planar papules and plaques
(6 P’s)
lichen planus
ptosis
miosis
anhidrosis
horner syndrome
sympathetic chain lesion
pupil accommodates but doesn’t react
neurosyphilis
argyll robertson pupil
rapidly progressive limb weakness that ascends following a GI/upper resp infection
guillain barre syndrome
acute inflammatory demyelinating polyradiculopathy subtype
rash on the palms and soles
coxsackie A
secondary syphilis
rocky mountain spotted fever
recurrent cold abscesses (non inflamed)
unusual eczema
high serum IgE
hyper IgE syndrome
job syndrome
due to neutrophil chemotaxis abnormalitiy
(staph abscesses)
red “currant jelly” sputum in alcoholic or diabetic patient
klebsiella pneumoniae pneumonia
red “currant jelly” stools
acute mesenteric ischemia (adults)
intussusception (children)
Red, itchy, swollen rash of the nipple/areola
paget disease of the breast
sign of underlying neoplasm
red urine in the morning
fragile RBCs
paroxysmal nocturnal hemoglobinuria
renal cell carcinoma (bilateral)
hemangioblastomas
angiomatosis
pheochromocytoma
von Hippel Lindau disease
dominant tumor supressor gene mutation
resting tremor rigidity akinesia postural instability shuffling gait
parkinsons disease
loss of dopaminergic neurons in substantia nigra pars compacta
retinal hemorrhages with pale centers
roth spots
bacterial endocarditis
severe jaundice in neonate
crigler najjar syndrome
congenital unconjugated hyperbilirubinemia
severe RLQ pain with palpation of LLQ
rovsing sign
acute appendicitis
severe RLQ pain with deep tenderness
McBurney sign
acute appendicitis
short stature cafe au lait spots thumb/radial defects increased incidence of tumors/leukemia aplastic anemia
fanconi anemia
genetic loss of DNA crosslink repair often progresses to AML
single palmar crease
down syndrome
situs inversus
chronic sinusitis
bronchiectasis
infertility
kartagener syndrome
dynein arm defect affecting cilia
skin hyperpigmentation
hypotension
fatigue
primary adrenocortical deficiency
aka addisons disease
causes increased ACTH and increased alpha MSH production
slow progressive muscle weakness in boys
becker muscular dystrophy
x linked missense mutation in dystrophin
less severe than duchenne
small irregular red spots on buccal/lingual mucosa with blue white centers
koplik spots
due to measles -rubeola- virus
smooth, moist, painless, wart like white lesions on genitals
condylomata lata
secondary syphilis
splinter hemorrhages in fingernails
bacterial endocarditis
“strawberry tongue”
scarlet fever
kawasaki disease
streak ovaries congenital heart disease horseshoe kidney cystic hygroma at birth short stature webbed neck lymphedema
turner syndrome
45XO
sudden swollen painful big toe joint
tophi (uric acid crystal deposits)
gout/podagra
hyperuricemia
swollen gums
mucosal bleeding
poor wound healing
petechiae
scurvy
vit C deficiency
cant hydroxylate proline/lysine for collagen synthesis
swollen hard painful finger joints
osteoarthritis
osteophytes on PIP (bouchard nodes) and DIP (heberden nodes)
systolic ejection murmur
crescendo-decrescendo
aortic stenosis
telangiectasias recurrent epistaxis skin discoloration arteriovenous malformations GI bleeding hematuria
osler weber rendu syndrome
hereditary hemorrhagic telangiectasia
thyroid tumor
parathyroid tymor
pheochromocytoma
MEN2A
autosomal dominant RET mutation
thyroid tumor
pheochromocytoma
ganglioneuromatosis (mucosal neuromas)
MEN2B
autosomal dominant RET mutation
toe extension/fanning upon plantar scrape
babinski sign
UMN lesion
unilateral facial drooping involving forehead
LMN facial nerve CN7 palsy
UMN lesions spare the forehead
urethritis
conjunctivitis
arthritis
in a male
reactive arthritis associated with HLA B27
vascular birthmark (port wine stain) of the face
nevus flammeus
benign but associated with sturge weber syndrome
vomiting blood following gastroesophageal lacerations
mallory weiss syndrome
alcoholics and bulimic patients
weight loss diarrhea arthritis fever adenopathy
whipple disease
tropheryma whipplei
“worst headache of my life”
subarachnoid hemorrhage
increased AFP in amniotic fluid/maternal serum
dating error
anencephaly
spina bifida (open neural tube defects)
anti-centromere antibodies
scleroderma
CREST
anti-desmoglein (anti-desmosome) ab’s
pemphigus vulgaris
blistering
anti-glomerular basement membrane ab’s
goodpasture syndrome
glomerulonephritis and hemoptysis
anti-histone ab’s
drug induced SLE
due to hydralazine
isoniazid
phenytoin
procainamide
anti- IgG ab’s
rheumatoid arthritis
systemic inflammation
joint pannus
boutonniere deformity
anti- mitochondrial ab’s (AMA’s)
primary biliary cirrhosis
female
cholestasis
portal HTN
anti-neutrophil cytoplasmic ab’s (ANCA’s)
microscopic polyangiitis
eosinophilic granulomatosis with polyagnittis
(MPO-ANCA/p-ANCA)
primary sclerosing cholangitis
(MPO-ANCA/p-ANCA)
granulomatosis with polyangiitis
(wegener; PR3-ANCA/c-ANCA)
anti-nuclear ab’s (ANA’s; anti-smith; anti-dsDNA)
SLE
type 3 hypersensitivity
anti-platelet ab’s
idiopathic thrombocytopenic purpura
anti-topoisomerase ab’s
diffuse systemic scleroderma
anti- transglutaminase/anti-gliadin/anti-endomysial ab’s
celiac disease
diarrhea
weight loss
“apple core” lesion on barium enema xray
colorectal cancer
usually left sided
atypical lymphocytes
EBV
azurophilic peroxidase plus granular inclusions in granulocytes and myeloblasts
auer rods
AML especially APML (promyelocytic) M3 type
bacitracin response
sensitive= strep pyogens GAS
resistance= strep agalactiae GBS
“bamboo spine” on xray
ankylosing spondylitis
chronic inflammatory arthritis
HLA B27
Basophilic nuclear remnants in RBCs
Howell Jolly bodies
due to splenectomy or non functional spleen
basophilic stippling RBCs
lead poisoning or sideroblastic anemia
bloody or yellow tap on LP
subarachnoid hemorrhage
“boot shaped” heart on xray
TOF
due to RV hypertrophy
branching gram positive rods with sulfur granules
actinomyces israeli
bronchogenic atypical lung tumor on imaging
pancoast tumor
can compress cervical sympathetic chain and cause horner syndrome
(lung apex tumor, causes shoulder pain)
“brown” tumor of bone
hyperparathyroidism
or
osteitis fibrosa cystica (deposited hemosiderin from hemorrhage gives brown color)
cardiomegaly with apical atrophy
chagas disease
trypanosoma cruzi
cellular crescents in Bowman capsule
rapidly progressive crescentic glomerulonephritis
“chocolate cyst” of ovary
endometriosis
frequently involves both ovaries
circular grouping of dark tumor cells surrounding pale neurofibrils
homer wright rosettes
neuroblastoma
medulloblastoma
colonies of mucoid pseudomonas in lungs
CF
autosomal recessive mutation in CFTR gene
fat soluble vitamin def and mucous plugs
decreased AFP in amniotic fluid/maternal serum
down syndrome
or
other chromosomal abnormalities
degeneration of dorsal column fibers
tabes dorsalis (tertiary syphilis)
subacute combined degeneration
(dorsal columns, lateral corticospinal, and spinocerebellar tracts affected)
“delta wave” on ekg
short PR interval
supraventricular tachycardia
wolff parkinson white syndrome
bundle of kent bypasses the AV node
depigmentation of neurons in the substantia nigra
parkinsons disease
basal ganglia disorder
rigidity
resting tremor
bradykinesia
desquamated epithelium casts in sputum
curschmann spirals
bronchial asthma
can result in whorled mucous plugs
disarrayed granulosa cells arranged around collections of eosinophilic fluid
call exner bodies
granulosa cell tumor of the ovary
dysplastic squamous cervical cells with “raisinoid” nuclei and hyperchromasia
koilocytes
HPV
predisposes to cervical cancer
electrical alternans
alternating amplitude on EKG
pericardial tamponade
enlarged cells with intranuclear inclusion bodies
“owl eye” appearance of CMV
enlarged thyroid cells with ground glass nuclei with central clearing
“orphan annie” eyes nuclei
papillary carcinoma of the thyroid
eosinophil cytoplasmic inclusion in the liver cell
mallory body
alcoholic liver disease
eosinophil cytoplasmic inclusion in the neuron
lewy body
parkinson disease and lewy body dementia
eosinophilic globule in the liver
councilman body
viral hepatitis, yellow fever
represents hepatocytes undergoing apoptosis
eosinophilic inclusion bodies in the cytoplasm of hippocampal and cerebellar neurons
negri bodies of rabies
extracellular amyloid deposition in gray matter of the brain
senile plaques
alzheimers disease
giant B cells with bilobed nuclei with prominent inclusions
“owl eyes”
Reed sternberg cells
HL
glomerulus like structure surrounding vessel in germ cells
schiller duval bodies
yolk sac tumor
“hair on end”
or “crew cut”
appearance on xray
beta thalaseema
sickle cell disease
due to marrow expansion
hCG elevated
choriocarcinoma
hydatidiform mole
(with and without embryo)
multiple pregnancy
heart nodules
granulomatous
anschoff bodies
rheumatic fever
heterophile ab’s
infectious mononucleosis (EBV)
hexagonal
double pointed
needle like crystals in bronchial secretions
bronchial asthma
charcot leyden crystals
eosinophilic granules
high level of D-dimer
DVT
PE
DIC
hilar LAD
peripheral granulomatous lesion in midline or lower lung lobes
(can calcify)
Ghon complex
primary TB, mycobacterium bacili
“honeycomb lung” on xray or CT
interstitial pulm fibrosis
hypercoagulability
leading to migrating DVTs and vasculitis
Trousseau syndrome
adenocarcinoma of pancreas of lung
hypersegmented neutrophils
megaloblastic anemia
B12 def= neuro symptoms
folate def= no neuro symptoms