Random Topics Flashcards
Match the Radial, Ulnar and median nerve damage to the observed result?
Radial: wrist drop
Ulnar: Claw Hand
Median: Thumb Opposition
Conditions with cervical spine anomalies
“Kid Try Gold”
Klippel Fleil
Trisomy 21
Goldenhar
Conditions with a small underdeveloped chin
"Please Get That Chin" Pierre-Robbins Goldenhar Treacher Collins Cri Du Chat
Conditions with Macroglossia
“Big Tongue”
Beckwith
Trisomy 21
Things that increase MAC
Chronic EtOH Increased CNS Neurotransmitters Hypernatremia Infants 1-6 months Hyperthermia Red Hair
Things that decrease MAC
Acute EtOH IV Anesthetics N2O Opioids Hyponatremia Older Age Prematurity Hypothermia
What are some causes of Low EtCO2
Hyperventilation (Pain, light anesthesia, metabolic acidosis)
Decrease CO2 production (Hypothermia)
Increased Alveolar dead space (Hypotension, PE)
How many Liters are in E-Cylinders based on gas
Air: 625L / 2000 PSI
O2: 660L / 2000 PSI
N2O 1590L / 745 PSI
Formula for dissolved O2
PaO2 x 0.003
Formula fo CaO2
CaO2 = (FiO2 x Hgb x 1.34) + (PaO2 x 0.003)
Formula for DO2
DO2 = CO x 10 x [(Hgb x Sa02 x 1.34) + (0.003 x Pa02)]
What is a priority in a patient with pyloric stenosis?
Correct volume status and electrolyte abnormalities
(medical NOT surgical emergency)
- Volume: 20 mL/kg
-
What are some post operative complications with pyloric stenosis?
Postoperative apnea
What is the function of the Lateral Spinothalamic Tract?
Pain and Temp
What is the function of the Ventral Spinothalamic Tract?
Crude Touch and pressure
What is responsible for fine touch and proprioception?
The Dorsal Column: Cuneatus and Gracilis
A common complication of ET intubation in pediatrics
Post- Intubation “Croup”
Facts about Croup Laryngeotracheal Bronchitis
- Barking Cough
- younger kids
- Viral
- Low fever
- Racemic Epi and Humidified O2
- Steeple sign
What are some complications of Bone cement?
- The First sign under GA is DECREASE EtCO2
- Emboli
- Bradycardia
- Hypotension ( dec SVR)
- pHTN (Inc PVR)
- Hypoxia
- Cardiac Arrest
Which procedure has the greatest risk of Bone Cement Implantation Syndrome (BCIS)?
Hip Arthroplasty
What is the First Line treatment for BCIS? Bone cement
100% FiO2
IV Hydration
Phenylephrine
(Treated as RT heart failure)
What hormones are secreted from Carcinoid tumors?
Histamine
Serotonin
Kinins & Kallikrein
Signs of Carcinoid crisis
Bronchoconstriction Flushing (head and neck) Supraventricular Tachydysrhythmias HTN/Hypotension Vasodilation/Vasoconstriciton Increased GI motility (ABD Pain, Diarrhea)
Drugs to avoid in patients with a carcinoid tumor?
- Sympathomimetics: Ketamine and ephedrine
- Histamine: Succ, Atracurium, morphine, meperidine, Thiopental
- Exogenous catecholamines
Drugs used in the treatment of carcinoid tumors?
- Octreotide/Ianreotide (somatostatin)
- Ondansetron (5HT3 Antagonist)
- Diphenhydramine + Rinatedine or Cimetidine (Antihistamines H1 & H2)
- Steroids
- Phenylephrine or vasopression for hypotension
What are the location of the nerves relative to the axillary artery?
Median Nerve: Anterior and medial
Ulnar Nerve: Posterior and Medial
Radial Nerve: Posterior and lateral
MSC Nerve: Anterior and Lateral
What coagulation issue occur with pre-eclampsia?
1) Thrombocytopenia
- consumptive
2) Increase thomboxane (by 7x)
3) decrease Prostacyclin
What is the most important site of pain modulation?
Rexed Lamina II & III (Substantia gelatinosa) of the Dorsal Horn
- the descending pathway begins in the periaqueductal grey and rostroventral Medulla
What are the pain inhibiting neurotransmitters?
Spinal: GABA and Glycine
Descending Pathway: NE, 5-HT3, and Endorphins
Pain is augmented by?
Wind-Up
Central Sensitization
What nerve is in charge of mastication?
Trigeminal V3 (Mandibular)
What are branches of the trigeminal nerve?
CN V
- V1: Opthalmic
- V2: Maxillary
- V3: Mandibular
What TV do you use in the neonate?
6 mL/kg
How do you confirm ETT placement in the neonate?
EtCO2
Chest Rise
Condensation in the tube
Increasing SaO2
Anesthetic management of MS?
- Aspiration Risk (D/t cranial nerve involvement)
- Avoid Hyperthermia and stress
- Succ can cause life-threatening hyperkalemia
What are the management techniques for Hypertrophic Cardiomyopathy?
Increase Preload (Volume/Phenylephrine)
Increase Afterload (Aortic Pressure): Phenylephrine
Decrease HR
Decrease Contractility
What medications Decrease PVR?
NO NTG PDEi (Sildenafil) Prostaglandins CCB ACEi Fentanyl (Treats pain)
What drugs INCREASE PVR?
N2O
Ketamine
Desflurane
What parameters increase PVR?
Hypoxia Hypercarbia Acidosis Hypothemia SNS stimulation Pain
What causes problems after aortic cross clamp removal?
Hypovolemia - Decrease venous return (preload) Dec Contractility Dec SVR Dec Preload/Afterload
What is the normal MA in a TEG and what does it measure?
Measures Clot strength
MA: 50-60
Evaluates platelets( PLT + DDAVP)
What is the normal R time in a TEG and what does is measure?
Time to begin forming clot
R: 6-8 min
Coagulation factors (give FFP)
What is the normal K time in a TEG and what does is measure?
Time till clot has achieved fixed strength
K: 3-7 min
Fibrinogen (Cryo)
What is the normal Alpha Angle in a TEG and what does is measure?
Speed of fibrin accumulation
Alpha Angle: 50-60 degrees
Fibrinogen (Cryo)
What is the normal A60 in a TEG and what does is measure?
A60: MA-5 Excess fibrinolysis (TXA)
What is the Max dose for neostigmine?
MAX: 5mg or 5000 mcg
range: 0.02-0.07 mg/kg
What are similar respiratory mechanisms changes in pediatric and elderly?
- Minute Ventilation (Increase)
- Closing Capacity (Increase)
- Residual volume (Increase)
- Vital Capacity (Decrease)
What drugs are dosed based in IBW?
- Propofol (Induction)
- Vecuronium/Rocuronium
- Sufentanil
- Remifentanil
What effect does the prone position have on hemodynamics?
- Improved V/Q
- Decreased venous pressure
- Improved venous return
What are some problems seen with hydralazine?
Reflex tachycardia
Lupus like symptoms
What are some problems with Sodium Nitroprusside?
Cyanide Toxicity
Methemoglobinemia
How does CO change during pregnancy?
Increases by 40 %
How does CO change during labor?
1st stage: 20%
2nd stage: 50%
3rd stage: 80%
When does CO return to prelabor values?
24-48 hours
When does CO return to pre-pregnancy values?
2 weeks
How does BP change during pregnancy?
Decreased diastolic BP
how do lung volumes change during pregnancy?
Decrease
- FRC
- RV
- ERV
- TLC
What clotting factors are decreased in pregnancy?
- Protein C & S
- XI & XIII
What effect does increased thromboxane have in pregnancy?
Increased
- platelet aggregation
- Vasoconstriction
- Uterine Activity
Decreased
- Uteroplacental Blood Flow
At what level does the Dural Sac end in Peds?
S3
S2 in 1 y/o
At what level does the spinal cord end in the neonate?
L3
What are the terminal branches of the brachial plexus?
MSC Radial Median Ulnar Axillary
List the cords?
Lateral
Posterior
Medial
List the trunks?
Superior
Middle
Inferior
The posterior Cord gives rise to the ________
Radial
Axillary
The lateral Cord gives rise to the _________
MSC
Median
The medial cord gives rise to the __________
Ulnar
What is the formula for Coronary perfusion pressure?
CPP = AoDBP - LVEDP (aka PAOP, PAWP, PCWP)
Relative indications for OLV?
Surgical Exposure
Pulmonary Edema s/p CABG
Severe Hypoxemia
Procedure risk factors of Ischemic Optic Neuropathy
Prone Wilson Frame Long duration of anesthesia large blood loss low colloid to crystalloid ratio hypotension
Landmarks for the Popliteal nerve block
Popliteal triangle
- semimembranous muscle (also the Semitendinosus) medially
- Biceps Femoris Laterally
- popliteal crease as the base
What are the disadvatages to the Beir Block (IV regional anesthesia)
LAST
Tourniquette Pain
No Post Operative Analgesia
Anatomical landmarks to the median nerve block at the wrist
Flexor Capri Radialis tendon (Thumb/lateral)
Palmaris Longus Tendon (Pinky/Medial)
What is the formula for Cerebral PP?
CPP = MAP - ICP or CVP (whichever is higher)
What agents can be use in hyperthyroid patients to treat signs of hyperthyroidism?
The 4 B’s
- BB: Esmolol, Propranolol
- Block Synthesis: PTU, Methimazole, Carbimazole, potassium iodide
- Block Release: radioactive iodine, potassium Iodide
- Block T4 to T3 conversion: Propranolol, PTU, Glucocorticoids
What drugs exacerbate Neuroleptic Malignant Syndrome (NMS)?
Dopamine Antagonists:
- Metoclopramide
- Haloperidol
- Risperidol
- Chlorpromazine
What is the treatment for NMS?
Dantrolene Bromocriptine Supportive Care ECT - Succ is safe
LMA cuff volume by size?
LMA 5: 40 LMA 4: 30 LMA 3: 20 LMA 2.5: 14 LMA 2: 10 LMA 1.5: 7 LMA 1.: 4
What causes systolic dysfunction?
Eccentric hypertrophy (Regurgitation) : Volume issue
What causes diastolic dysfunction?
Concentric hypertrophy (LV thickening): Pressure (AS)
What does SIADH cause?
Hypervolemic Hypotonic Hyponatremia
What are some drugs that prolong the QT interval?
Ondasetron Methadone Droperidol Haloperidol Halogenated anesthetics (Sevo) Amiodarone Quinidine
Metabolic disturbances that prolong Qt interval?
Hypokalemia
Hypocalcemia
Hypomagnesemia
List some Opioid agonist antagonist
(Kappa Agonist/ Mu Antagonist)
Nalbuphine
Butorphanol
List a partial opioid agonist that is not reversed by Naloxone ?
Buprenorphine
Partial Mu Agonist
Drugs that inhibit COX
Non-Selective
- ASA, Ketorolac, Diclofenac, Naproxen, Ibuprophen, Indomethacin
Selective COX-2
- Coxib ending (celecoxib)
The O2 flush valve bypasses what?
The Low pressure system
- Vaporizer
- Check Valve
- Thorpe Tube
What is the first step in the pre-anesthesia checkout?
Verify auxiliary oxygen cylinder and self inflating manual ventilation device are available and functioning
- AKA check emergency equipment
What patients do you not give ergot alkaloids?
Ergot Alkaloid = Methergine
- to patients with HTN (aka preeclampsia, PIH,)
What patients do you not give Carbapost/hemabate?
Asthamtics
What BP indicates severe pre-eclampsia?
> 160 SBP
110 DBP
(d/t increased thromboxane)
What are some postoperative considerations for the obese patient?
Minimize meds that suppress the respiratory system (d/t OSA)
- use short acting drugs, avoid opioids/benzos
What is the parkland formula?
4ml x % BSA burned x kg = volume of fluid to give
What does the Train of Four correlate with?
70% blockade
What are the best indicators of adequate recovery from NMB?
50% blockade
- Bite Tongue blade against force
- Head Lift > 5second
- Hand grip > 5 seconds
- Negative Insp Force > -40 cm H2O
What does the TV of 5mL/kg correlate with? (in reference to nuero blockade)
80% blockade
What nerve can be missed with an inter scalene block?
Ulnar Nerve (C8-T1)
Complications from inter scalene block?
Horners Syndrome (Very Horny PAM)
Phrenic Nerve Paralysis (100% of the time)
Missed Ulnar Nerve
How does the BP change above or below the heart?
- for every 10 cm a change of 7.4 mmHg (or 1cm = .74mmHg)
- for every 1 inch a chance of 2 mmHg
What are some of the risk associated with Jet ventilation?
Pneumothorax (most common) Barotrauma Sub Q emphysema/ Mediastinal Emphysema Hemorrhage Aspiration tracheal injury Esophgeal injury (At risk of Hypercapnia)
What effect does hyperventilation have on electrolytes?
Decreases K and Ca (less ionized bc it binds to proteins)
Hematologic changes seen with a pneumoperitoneum?
- Increased: SVR, MAP, PVR, A-a gradient (V/Q Mismatch), ICP, CPP, Afterload
- Decreased: Splenic and RBF, FRC, Venous return
- CO Maintained or decreased
What are some relative contraindications to lithotripsy?
AICD/PPM Calcified aneurysm of aorta or renal artery Untreated UTI Obstruction beyond renal stone Morbid Obesity
What are some absolute contraindications to lithotripsy?
Risk of bleeding (Coagulopathy)
Pregnancy
What are complications from mediastinoscopy?
Most Common:
- Hemorrhage
- tension Pneumothorax (usually right sided)
Others
- Phrenic or RLN damage
- Chylothorax (thoracic duct)
- Innominate artery compression (Decreased cerebral and carotid Blood Flow)
- reflex Bradycardia
What are the absolute contraindications to mediastinoscopy?
Previous mediastinoscopy
What are the RELATIVE contraindications to mediastinoscopy?
Tracheal deviation
Thoracic Aortic Aneurysm
SVC obstruction
What is a significant risk of TIPS procedure?
Hemorrhage
- tachycardia, desaturation
Function of Alpha cells in the pancreas
Alpha-2 cells decrease insulin release from pancreatic islet cells
What is the dose for bupivicaine?
- 5 mg/kg
- 3.0 mg/kg with Epi
What is the MOA of LMWH?
Factor Xa Inhibitor
- Enoxaparin
- Dalteparin
- Tinzaparin
What are the guidelines for neuraxial anesthesia with LMWH?
Once daily: wait 12 hrs
Twice daily: wait 24 hours
Hold 12 hours before removing catheter
- may continue 2 hours after removal
What are the criteria for GAP Acidosis?What are the causes?
Anion Gap > 14 MUDPILES - Methanol - Uremia - Diabetic Ketoacidosis - Paraldehyde - Isonazid - Lactic acidosis (cyanide poisoning) - Ethanol - Salicylates
What are some causes of NON-anion gap acidosis?
HARDUP (think increased output conditions)
- Hypoaldosteronism
- Acetazolamide
- Renal Tubular Acidosis
- Diarrhea
- Ureterosigmoid Fistula
- Pancreatic Fistula
Also Large volume resuscitation with NaCl
What ligament extends from the foramen magnum to the sacral hiatus?
Ligamentum Flavum
What are the landmarks for the sciatic nerve block?
Greater trochanter (Hip)
Sacral Hiatus
Posterior Superior Illiac Spine (PSIS)
What is Virchows Triad?
3 categories that are thought to contribute to thrombosis
- Venous Stasis
- Hypercoagulability
- Endothelial Injury
Why do peds need a higher dose of Succinylcholine?
Increase ECV
What is the MOA of Methadone?
NMDA Antagonist*
Mu Agonist
MAOI
What is a complication from meperidine?
QT prolongation
Meperidine works on which receptor to stop shivering?
Kappa*
Its has mixed Mu and Kappa effects
What is the problem with meperidine metabolism
Active metabolite Noremeperedine causes seizure
- DO not give to elderly or renal patients
What conditions is omphalocele associated with?
Beckwith-Weidmen*
Trisomy 21
Cardiac Defects
What are the signs and symptoms of diaphragmatic Hernia?
Cyanosis* Dyspnea* Dextrocardia* scaphoid abdomen pHTN Pulmonary hypoplasia
What can cause uterine atony?
Macrosomia (Lg fetus)* Forceps Delivery* (Instrumentated Labor) multiparty Multiple gestation Polyhydraminos Prolonged Pitocin Infusion
What factors are in Cryoprecipitate?
Fibrinogen (Factor I),
Factor VIII,
Factor XIII,
vWF,
Fibronectin
What Factors increase in pregnancy?
fibrinogen (Factor I)*
everything except XI, XIII, Protein C & S
What are the facto of Quaternary NMB’s?
Highly Ionized
DO NOT cross the placenta
What is a Rhizotomy?
Ablates neural impulses so it does not reach the spinal cord*
- Severs Nerve roots in the spinal cord
What is a side effect of vasogenic twitching with epilepsy?
Diplopia*
What are some consideration for patients undergoing strabismus surgery?
Increased risk of
- MH (Masseter Spasm*)
- PONV
- Occulocardiac reflex
What is commonly used for pain?
Antidepressants*
What is commonly used for chronic pain?
GABA Agonist (Gabapentin)* SSRI's*
What is the best indication for a lighter stylet?
Unstable Cervical spine*
Anterior Airway*
Blood in airway
small mouth opening
What is the function of each: CMAC Glidescope King Air Traq
C-MAC: can use as DL
Glide: 60 Degree angle
King: 90 Degree
Air Traq: Prisms and Lenses
What is the most common complication from Liposuction?
PE*
Max dose for tumescent anesthesia?
55 mg/kg
What is the muscle response for the following nerves Radial Musculocutaneous Tibial Peroneal
Radial: Triceps contraction
MSC: Biceps contraction
Tibial: Plantar Flexion
Peroneal: Dorsiflexion
Respondeat superior, which is “borrowed servant” is under what?
Vicariouse Liability
In what population does succinylcholine cause increased potassium?
ALS GBS MH MS DMD Charcot Marie Tooth Hyperkalemic Periodic Paralysis
In what population is it safe to give succinylcholine?
Myasthenia Gravis*
PArkinsons*
Eaton Lambert (decrease dose d/t increased sensitivity)
What is responsible for the fast onset of intrathecal opioids?
Lipid solubility
What effect of EPI would be blocked by phentolamine but not metoprolol?
Pancreatic Islet Cells (Alpha 2)
What do you mix dantrolene with?
Bacteriostatic water
What is the purpose of the two vertical bars on the LMA?
prevents epiglottis from blocking the airway
What does elevated ALT and AST indicate?
Hepatocellular injury *
- ALT is specific to the Liver
Why would conjugate bilirubin be increased?
Billiary obstruction
What are some signs of Cirrhosis?
Decreased effect plasma volume,
Decreased oncotic pressure,
Hyponatremia
What is in the inter vascular space but not in the intersistial space?
Plasma proteins
What is not made by the liver?
Immunoglobulins
What happens in DIC?
- Increased Pt, PTT, D-Dimer and fibrin spilt products*
- Decreased Fibrinogen (factor I), antithrombin and platelets*
- Increased fibrin and microvascular thrombosis*
What nerve innervates the medial aspect of the upper arm?
The intercostalbrachialis*
What is a sign of endobronchial intubation
Normal EtCO2 but increase PIP and decrease SpO2*
What are 2 thoracolumbar conditions that will make intubation difficult?
Kyphoscoliosis*
Large Chest *
Which fibers have golgi body spindles?
A-Alpha (Muscle)*
Why is epidural dosing less for pregnancy?
Engorged epidural vein*
increased sensitivity to LA*
Increased spread
Why do we decrease spinal dose in pregnancy?
Decreased CSF volume*
What is the most common complication from Jet ventilation?
Pneumothorax*
What meds would require an decreased dose in liver disease?
Succ and roc
Which cells secrete Heparin?
Basophils
ST elevation indicates what type of ischemia?
Transmural ischemia
What is the best monitor after no TOF?
Post-Tetany
Patient in the prone position and an object is resting on the posterior lateral aspect of the arm, what nerve can be injured?
Radial
The patient is post cardiac surgery and becomes tachycardia with nothing draining from the chest tube, you should suspect?
Cardiac Tampnade
Hypovolemia in pediatrics can cause?
Increased dead space
Patient has transection at C4, what muscles will help with respiration?
Cervical Stap Muscles
Which muscle is least resistant to NMB?
Diaphragm
Where does the dural sac end in the neonate?
S3
What interrupts non shivery thermogenesis?
BB
pKa 6.2 Bicarb to carbonate ratio is 20:1, What its the pH?
pH = pKa + Log (base/acid)
pH 7.4
Define IRV?
The amount of gas that can be forcibly inhaled after tidal breath
Define each:
Half Life:
Half time
Terminal half-life time:
- Half Life: The time is takes for 50% of the drug to be removed from the body after rapid IV injection
- Half time: The time is takes for 50% of the drug to be removed from the plasma during the elimination phase
- Terminal half-life time: time it takes for the drug concentration in the blood to fallibly 1/2 of its current value
How do lung volumes change during pregnancy?
Increase VT* Increased IRV* Increase MV Decreased ERV Decreased RV Decreased FRC
Where to block the median nerve at the upper arm?
Elbow: at the lateral humerus epicondyle lateral to the brachiocephalic artery
- Medial to the brachial artery at the antecubital fossa
What do you do if pipeline pressure fails?
Disconnect pipeline, turn tank on
What nerve branches do u need to block for surgery of the dorsal of the foot?
Sciatic (to get Sural and peroneal))
Common peroneal
What artery can be damaged during transphenoidal surgery?
INTERNAL CAROTID
What is the concern with hypotension during lithotomy?
Compartment syndrome
releasing the TQT produces what changes?
Inc EtCO2 Dec Temp Dec BP Dec SpO2 Dec pH (Metabolic Acidosis)
What causes the release of renin?
Low Na*
SNS Activation
Decreased renal perfusion pressure (PEEP, Hemorrhage)
What does a cobb angle of 70 degrees indicate?
Decreased VC
What is a side effect of tocolytics?
Pulmonary edema
What are some disadvantages of SubQ defibrillator?
No standard pacing successive shocks
CV changes in supine position?
Inc CO
Inc preload
What drugs increase the required dose of NMB, pick 2?
- Rifampin (inducer)
- Carbamazepime, Barbs, ethanol, Tamoxifen
Minimum distance of monopoler cautery from pacer?
15 cm
What is the cardiac output to each tissue group?
Vessel Rich Group 75%
Muscle 19%
Fat 6%
Vessel Poor < 1%
What would effect NIMS tube with EMG monitoring
Succ and Roc
Lido LTA
Why do we use Mag drip for ERAS?
Decrease post op opioids
What is the biggest concern with pituitary surgery (hypothalamus)?
Diabetes Insipidus (DI): lack of ADH
What drugs not to use with porphyria?
Phenytoin* Lidocaine* Thiopental* Etomidate barbs
List the arterial waveform seen witch each condition Left heart Failure Cardiac tamponade Aortic Stenosis Aortic Regurgitation
Left heart Failure: Pulsus Alternans ( beat to beat variability)
Cardiac tamponade : Pulsus Paradoxus
Aortic Stenosis: Pulsus Parvus (looks like A)
Aortic Regurgitation: Bisurfens Puslse (looks like M)
Disadvantages of measuring stump pressures?
Embolic stroke
Not routinely used
Nerve injury with sternal retraction?
Brachial Plexus that manifest in as Ulnar nerve issue
What must be proved for malpractice claim?
Duty
Breach of duty
Causation
Damages
Primary method of heat loss in burn patients
Evaporation
Systolic filling correlates with what part of the CVP waveform?
V Wave
what is hemophilia A
Factor 8 deficiency (give cryo)
What is a consideration with patients on doxorubicin?
Cardiotoxicity- get Echo for EF
What condition will have sustained muscle contraction after succinylcholine?
Myotonic Dystrophy
When to give FFP?
PT and/or PTT 1.5 normal
What is a treatment for apnea in peds
caffeine and theophylline