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Pharm - Drugs > Random Shit! > Flashcards

Random Shit! Flashcards

1
Q

Breast Cancer : Principal site of metastasis

A

bone, lung, liver, brain

  • mostly Bone
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2
Q

Lung adenocarcinoma: Principal site of metastasis

A

brain, bone, adrenal gland, liver

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3
Q

Skin Melanoma: Principal site of metastasis

A

Lung, Brain, Skin, Liver

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4
Q

Colorectal Cancer:Principal site of metastasis

A

Liver and Lung

- metastasize to local lymph node then to liver

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5
Q

Pancreatic Cancer: Principal site of metastasis

A

Liver and Lung

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6
Q

Prostate Cancer Principal site of metastasis

A

Bone

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7
Q

Sarcoma :Principal site of metastasis

A

Lung

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8
Q

Vinyl Chloride can cause:

A

liver angiosarcoma

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9
Q

Benzene can cause:

A

acute leukemia

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10
Q

Arsenic can cause:

A

skin carcinoma, bladder cancer

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11
Q

asbestos can cause:

A

mesothelioma

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12
Q

Radium can cause:

A

osterosarcoma

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13
Q

Tumor Initiator:

A

Can sow the seeds of cancer, 1 exposure does not cause cancer.

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14
Q

Tumor promoter:

A

can cause cancer if tissue is previous exposed to tumor initiator

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15
Q

BRAF mutation –> what common cancer? :

A

Melanoma

- intracellular signaling

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16
Q

HER mutation –> what common cancer? :

A

Breast Cancer

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17
Q

MYC mutation –> what common cancer? :

A

Many Cancers

- TF

18
Q

RAS mutation –> what common cancer? :

A

Colorectal

19
Q

VEGF mutation –> what common cancer? :

A

Mesastatic Colorectal

20
Q

WT1mutation –> what common cancer? :

A

Wilm’s tumor (nephroblastoma)

- TF

21
Q

NF1: mutation –> what common cancer? :

A

Schwannomas

  • Schwann Cells tumor
  • GTPas
22
Q

p16mutation –> what common cancer? :

A

mesothelioma/ melanoma

- CDKI

23
Q

Lifraumeni Syndrome:

  • 45 yo female
  • breast carcinoma twice
  • sarcoma in calf muscle
  • adrenal carcinoma
A

p53

24
Q

Cowden’s Syndrome:

  • 30 yo women
  • strong history of breast cancer
  • exam skin
A

PTEN

25
Q

GIST : Gastrointestinal tumor

  • 60 yo
  • decrease appetite
  • tumor in mesentary
A

c-Kit

26
Q

Lung Cancer:

  • EGFR : active PI3K/AKT
  • more active in asian, mutation in 5% of smokers, 15% non-smokers, 50% never smoke
A
  • used Erlotinib (Tarceva) (pill better than IV)
  • Chest xray shows pleural effusion and mass in right lung
  • adenocarcinoma tend to be small and peripheral
  • pills can produce better effects than drugs
27
Q

EML4-ALK mutation in lung cancer

A 
5% of lung cancer
- usually adenocarcinoma
- asian, female, nonsmokers
Crizotinib (Xalkori)
57% response / 72% free in 6 mo.
28
Q

Head and Neck Cancer

58 yo male w/ R mass neck. tonsil mass
- squamous cell carcinoma

A
  • EGFR
  • use cetuximab (erbitux)

4 grades of gliomas

29
Q

Glioblastoma:
72 yo male
- headache, left leg weakness
- necrotic mass in right brain

A
  • gliomas are most common brain neoplasm
  • Grade 1-2: benign
  • Grade 3-4: malignant
    Grade 4: glioblastoma
  • VEGF Inhibitors: Bevacizumab
30
Q

Renal cell Carcinoma:
66 yo AAM
- iron deficiency anemia
- gross hematuria, mass in kidney

A

VEGF TKI: Sunitinib

31
Q

Which cancer had its mortality cut in half with inhibition of its pathway?

A

CML

32
Q 
Chronic Myeloid Leukemia:
54 yo CC: fatigue
- enlarged spleen
WBC: 56,000 
t(9,22)
A

BCR-ABL inhibitor

33
Q

Breast Cancer:
67 yo female
breast cancer to bone

A

EGFR with + estrogen
- Tamoxifen

  • then can add mTOR
34
Q

Breast Cancer: Her2/NEU +

A

Herceptin

35
Q

Prostate Cancer
78 yo farmer
bone pain
PSA 223

A

Androgen Receptor Blockade:

Enzalutamide (Zytiga)

36
Q

Melanoma:

26 yo surfer

A

BRAF V600E/K

Vemurafenib (Zelboraf)

37
Q

Basal Cell carcinoma

  • 79 yo homeless man
  • large tumor anterior to left ear
A

Hedgehog system

- Vismodegib (Erivedge)

38
Q

t(14,18)

A

follicular lymphoma

  • BCL2 fusion to IgH locus of chromosome 14
  • 60 yo: no tx
39
Q

4 stages of tumor invasion

A

1) detachment: E-cadherin
2) degradation of basement membrane: MMP9
3) attachment: laminin fibronectin receptors
4) migration : autocrine factors

40
Q

Tumor Embolus:

A

tumor cells invade veins, then to R heart and lungs

41
Q

Organ Tropism:

A

CXC4 / CCR7

Pharm - Drugs (9 decks)

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