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Pharm - Drugs > Anti-Cancer > Flashcards

Anti-Cancer Flashcards

1
Q

Gefitinib

A

EGFR inhibitor

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2
Q

Imatinib

A

BCR-ABL Tyr Kinase inhibitor

  • stress on the ER, cardiotoxicity
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3
Q

Rituximab

A

CD-20 target mAb

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4
Q

Alemtuzumab

A

CD-52 target mAb

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5
Q

Trastuzumab

A

Her2-Neu/ EGFR target mAb

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6
Q

Lapatinib

A

EGFR Tyr Kinase Inhibitor

  • prolong QT
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7
Q

Dasatinib

A

BCR-ABL Tyr-Kinase Inhibitor

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8
Q

Erlotinib

A

EGFR inhibitor

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9
Q

Gemtuzumab

A

EGFR2/ Her2-Neu

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10
Q

Ofatumumab

A

CD-20 targeted mAb

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11
Q

Tositumonab

A

CD-20 targeted mAb

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12
Q

Bevacizumab

A

VEGF inhibitor

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13
Q

Panitumumab

A

EGFR1/ Her-1

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14
Q

Ibritumomab

A

CD20 Targeted

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15
Q

Cetuximab

A

EGFR-1/ HER-1

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16
Q

Sirolimus

A

mTOR inhibitor

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17
Q

Sunitinib

A

VEGF TKI

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18
Q

Everolimus

A

mTOR inhibitors

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19
Q

Sorafenib

A

VEGF TKI

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20
Q

Pazopanib

A

VEGF TKI

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21
Q

IFN-alpha 2a

A
  • peginterferon,
  • promote cell cycle arrest in G0
  • induce apoptosis
  • induce immunological response

AE: neuropsy, flu symptoms, neutropenia

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22
Q

Bortezomib

A

Inhibit IKK complex with NEMO degradation by blocking 26S proteosome

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23
Q

Factors influencing Chemotherapeutic response?

A

PK, tumor cell specific, tumor microenvironment

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24
Q

When do you use Allopurinol or Rasburicase?

A

Tumor Lysis Syndrome

  • reduce uric acid/ renal protection
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25
Q

Mensa is used with _____________ and for _______________?

A

cyclosporamide and ifosfamide

  • protect against acrolein product
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26
Q

Amifostine is used with _____________ and for _______________?

A

Cisplatin, cytoprotection

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27
Q

Leucovorin is used with _____________ and for _______________?

and what else

A

MTX: metabolic rescue

5-FU: enhanced rxn

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28
Q

Allopurinol is used with _____________ and for _______________?

A

6-MP: increase toxicity

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29
Q

Dexroxazone is used with _____________ and for _______________?

A

Anthracyclines: Fe-chelator and reduce cardiotoxicity

30
Q

Pamidronate and Zoledronate are used with _____________ and for _______________?

A

Bone metastases: reduce bone pain and fracture

31
Q

Cardiotoxicity is associated with what?

A

anthracyclines

32
Q

Hypotension is associated with what?

A

IL-2 drugs, alemtuzumab, INF-a

33
Q

Hypertension is associated with what?

A

Bevacizumab, Sorafenib, Sunitinib

34
Q

Edema is associated with what?

A

Imatinib

35
Q

QT prolongation is associated with what?

A

sorafenib, sunitinib

36
Q

Thrombo-embolic complication is associated with what?

A

Bevacizumab, Thalidomide, Estramustine

37
Q

Cumulative Neurotoxicity is associated with what?

A

Vincristine

38
Q

GI toxicity, avoid in Gilbrett syndrome, AchE inhibition are associated with what?

A

Irinotecan

39
Q

Stocking-glove is associated with what?

A

Paclitaxel

40
Q

Docataxel is associated with what?

A

Edema-fluid retention

41
Q

Cardiotoxicity is associated with what?

A

Anthracyclines and Mitoxantrone

42
Q

GI toxicity is associated with what?

A

Dactionomycin

43
Q

Pulmonary Fibrosis is associated with what?

A

Bleomycin

44
Q

Pancreatitis is associated with what?

A

Asparinginase

45
Q

Bischloroethylamine Alkylating Agents:

A

cyclophosphamide, ifosfamide, merchlorethamine, melphalan, chlorambucil

46
Q

Cyclophosphamide properties

A
  • transfer alkyl group to DNA
  • N7 G
  • dose related toxicity
  • reproductive system toxicity: oligospermia/amenorrhea
  • N/V relieved by ondansetron
  • Lung toxicity
  • Renal failure (proximal tubules
47
Q

Busulfan properties

A
  • PO/IV
  • hydrolysis in aq. solution
  • veno-occlusive disease of liver
48
Q

Carmustine / Lomustine

A
  • carbamyolyate proteins: inhibit DNA repair
  • highly lipophilic –> center CNS and can cause neuro problems
    Car: IV
    LO: PO
49
Q

Thiotepa

A

Lipophilic

Neurotoxic

50
Q

Mitomycin C

A

ROS

51
Q

Cisplatin

A
  • react w/ water
  • intrastrand DNA links
  • IV only
  • Nephrotoxic –> admin what?
  • ototoxicity
  • progressive peripherial neuropathy
52
Q

Dacarbazine

A

DNA methylating agent

  • myelosuppression
  • O6 G

temozolomide is similar

53
Q

Procarbazine

A

highly DNA methylator

  • weak MAO: hypertensive
  • Disulfiram-like actions
54
Q

MTX

A
  • polyGlu

- Leuvocorin rescue

55
Q

5-FU

A

IV

  • hand foot syndrome
  • Leuvocorin enhance toxicity
56
Q

Carpecitabine:

A

oral, like 5-FU

  • handfoot syndrome more likely
  • erase fingerprint
57
Q

Cytarabine/ ARA-C

A

convert top ARA-CTP

  • multiple DNA duplication
  • noncardiogenic pulmonary edema
58
Q

Gemcitabine:

A

1 additional DNA base-pair added

- affinity for kinase

59
Q

6MP/ mercatopurine

A
  • erythocyte TPMT

- allopurinol –> 6-thiouric acid

60
Q

Fludarabine and Caladribine

A

Re-Phosphorylation

- inhibit DNA synthesis and ribonuclease reductase

61
Q

Vinca Alkaloid

A

IV

  • hepatic elimination
  • extremity numbness (hot water/ cold hand)
62
Q

Camptothecin:

A

DNA topo1

63
Q

Irinotecan and Topotecan:

A

dose limiting diarrhea

- topo 1

64
Q

Anthracyclins:

A

Daunorubicin/ Doxorubicin/ Mitoxantrone

  • topo II/ DNA
  • free radical from semiquinone
  • intercalated w/ DNA
  • multiple mechanisms
65
Q

Topo II inhibitors:

A

etoposide: oral
teniposide: IV

66
Q

Bleomycine

A

Drug-Fe complex

- resistance: hydrolase

67
Q

Actinomycin D:

A

intercalated DNA

- free radical and Topo II

68
Q

L-asparaginase

A

IV

  • potentially fatal
  • pegaspargase: safe alt.
69
Q

Hydroxyurea:

A
  • free radical scavenger

- ribonucleotide reductase

70
Q

Thalidomide:

A

inhibit proliferation, adhesion, angio, enhance NK

Pharm - Drugs (9 decks)

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