Anti-Cancer Flashcards
1
Q
Gefitinib
A
EGFR inhibitor
2
Q
Imatinib
A
BCR-ABL Tyr Kinase inhibitor
- stress on the ER, cardiotoxicity
3
Q
Rituximab
A
CD-20 target mAb
4
Q
Alemtuzumab
A
CD-52 target mAb
5
Q
Trastuzumab
A
Her2-Neu/ EGFR target mAb
6
Q
Lapatinib
A
EGFR Tyr Kinase Inhibitor
- prolong QT
7
Q
Dasatinib
A
BCR-ABL Tyr-Kinase Inhibitor
8
Q
Erlotinib
A
EGFR inhibitor
9
Q
Gemtuzumab
A
EGFR2/ Her2-Neu
10
Q
Ofatumumab
A
CD-20 targeted mAb
11
Q
Tositumonab
A
CD-20 targeted mAb
12
Q
Bevacizumab
A
VEGF inhibitor
13
Q
Panitumumab
A
EGFR1/ Her-1
14
Q
Ibritumomab
A
CD20 Targeted
15
Q
Cetuximab
A
EGFR-1/ HER-1
16
Q
Sirolimus
A
mTOR inhibitor
17
Q
Sunitinib
A
VEGF TKI
18
Q
Everolimus
A
mTOR inhibitors
19
Q
Sorafenib
A
VEGF TKI
20
Q
Pazopanib
A
VEGF TKI
21
Q
IFN-alpha 2a
A
- peginterferon,
- promote cell cycle arrest in G0
- induce apoptosis
- induce immunological response
AE: neuropsy, flu symptoms, neutropenia
22
Q
Bortezomib
A
Inhibit IKK complex with NEMO degradation by blocking 26S proteosome
23
Q
Factors influencing Chemotherapeutic response?
A
PK, tumor cell specific, tumor microenvironment
24
Q
When do you use Allopurinol or Rasburicase?
A
Tumor Lysis Syndrome
- reduce uric acid/ renal protection
25
Mensa is used with _____________ and for _______________?
cyclosporamide and ifosfamide
- protect against acrolein product
26
Amifostine is used with _____________ and for _______________?
Cisplatin, cytoprotection
27
Leucovorin is used with _____________ and for _______________?
and what else
MTX: metabolic rescue
5-FU: enhanced rxn
28
Allopurinol is used with _____________ and for _______________?
6-MP: increase toxicity
29
Dexroxazone is used with _____________ and for _______________?
Anthracyclines: Fe-chelator and reduce cardiotoxicity
30
Pamidronate and Zoledronate are used with _____________ and for _______________?
Bone metastases: reduce bone pain and fracture
31
Cardiotoxicity is associated with what?
anthracyclines
32
Hypotension is associated with what?
IL-2 drugs, alemtuzumab, INF-a
33
Hypertension is associated with what?
Bevacizumab, Sorafenib, Sunitinib
34
Edema is associated with what?
Imatinib
35
QT prolongation is associated with what?
sorafenib, sunitinib
36
Thrombo-embolic complication is associated with what?
Bevacizumab, Thalidomide, Estramustine
37
Cumulative Neurotoxicity is associated with what?
Vincristine
38
GI toxicity, avoid in Gilbrett syndrome, AchE inhibition are associated with what?
Irinotecan
39
Stocking-glove is associated with what?
Paclitaxel
40
Docataxel is associated with what?
Edema-fluid retention
41
Cardiotoxicity is associated with what?
Anthracyclines and Mitoxantrone
42
GI toxicity is associated with what?
Dactionomycin
43
Pulmonary Fibrosis is associated with what?
Bleomycin
44
Pancreatitis is associated with what?
Asparinginase
45
Bischloroethylamine Alkylating Agents:
cyclophosphamide, ifosfamide, merchlorethamine, melphalan, chlorambucil
46
Cyclophosphamide properties
- transfer alkyl group to DNA
- N7 G
- dose related toxicity
- reproductive system toxicity: oligospermia/amenorrhea
- N/V relieved by ondansetron
- Lung toxicity
- Renal failure (proximal tubules
47
Busulfan properties
- PO/IV
- hydrolysis in aq. solution
- veno-occlusive disease of liver
48
Carmustine / Lomustine
- carbamyolyate proteins: inhibit DNA repair
- highly lipophilic --> center CNS and can cause neuro problems
Car: IV
LO: PO
49
Thiotepa
Lipophilic
| Neurotoxic
50
Mitomycin C
ROS
51
Cisplatin
- react w/ water
- intrastrand DNA links
- IV only
- Nephrotoxic --> admin what?
- ototoxicity
- progressive peripherial neuropathy
52
Dacarbazine
DNA methylating agent
- myelosuppression
- O6 G
temozolomide is similar
53
Procarbazine
highly DNA methylator
- weak MAO: hypertensive
- Disulfiram-like actions
54
MTX
- polyGlu
| - Leuvocorin rescue
55
5-FU
IV
- hand foot syndrome
- Leuvocorin enhance toxicity
56
Carpecitabine:
oral, like 5-FU
- handfoot syndrome more likely
- erase fingerprint
57
Cytarabine/ ARA-C
convert top ARA-CTP
- multiple DNA duplication
- noncardiogenic pulmonary edema
58
Gemcitabine:
1 additional DNA base-pair added
| - affinity for kinase
59
6MP/ mercatopurine
- erythocyte TPMT
| - allopurinol --> 6-thiouric acid
60
Fludarabine and Caladribine
Re-Phosphorylation
| - inhibit DNA synthesis and ribonuclease reductase
61
Vinca Alkaloid
IV
- hepatic elimination
- extremity numbness (hot water/ cold hand)
62
Camptothecin:
DNA topo1
63
Irinotecan and Topotecan:
dose limiting diarrhea
| - topo 1
64
Anthracyclins:
Daunorubicin/ Doxorubicin/ Mitoxantrone
- topo II/ DNA
- free radical from semiquinone
- intercalated w/ DNA
- multiple mechanisms
65
Topo II inhibitors:
etoposide: oral
teniposide: IV
66
Bleomycine
Drug-Fe complex
| - resistance: hydrolase
67
Actinomycin D:
intercalated DNA
| - free radical and Topo II
68
L-asparaginase
IV
- potentially fatal
- pegaspargase: safe alt.
69
Hydroxyurea:
- free radical scavenger
| - ribonucleotide reductase
70
Thalidomide:
inhibit proliferation, adhesion, angio, enhance NK
