Immunosuppressants

Question 1

Name the polyclonal IgG against human T-lymphocytes

Answer 1

Antithymocyte Globulin (Atgam-horse monoclonal; Thymoglobulin- rabbit monoclonal)

Question 2

Name the co stimulatory molecules

Answer 2

Muromonav-CD3 (Orthoclone CD3), Belatacept (NULOJIX)

Question 3

Name the CD-25 Inhibitors

Answer 3

Daclizumab(Zenapax), Basiliximab (Simulect)

Question 4

Name the calcineurin inhibitors

Answer 4

Cyclosporine, Tacrolimus, Pimecrolimus

Question 5

Name the Nuclear Transcription Inhibitors

Answer 5

Methylprednisolone

Question 6

Name the mTOR Inhibitors

Answer 6

Sirolimus

Question 7

Name the Cell cycle disruptors

Answer 7

Mycophenolate mofetil, Azathioprine, Methotrexate, Cyclophosphamide

Question 8

What is Induction?

Answer 8

At time of transplantaion, High Dose, Individualized to patient (donor specific transfusion or irradiation as drug alternatives)

Question 9

What is Maintenance?

Answer 9

While transplant organ is in recipient, low dose (tolerable in chronic use; not without side effects)

Question 10

What is Rescue?

Answer 10

When organ is being rejected; high does, chronically intolerable