Random antibodies + tests Flashcards

1
Q

Anti-mitochondrial antibody

A

Primary biliary cirrhosis

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2
Q

p-ANCA

A

Ulcerative colitis

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3
Q

Ham test

A

Paroxysmal nocturnal hemoglobinuria

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4
Q

anti-GAD

A

T1DM

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5
Q

anti-smooth muscle antibody

A

autoimmune hepatitis

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6
Q

Osmotic fragility test

A

hereditary spherocytosis

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7
Q

anti-endomysial antibodies

A

coeliac disease

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8
Q

anti-scl70 antibody

A

Diffuse scleroderma

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9
Q

anti-dsDNA antibodies

A

SLE

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10
Q

c-ANCA

A

wegener’s granulomatosis

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11
Q

Anti-Ro

A

Sjogren’s
SLE
Mixed CTD

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12
Q

Anti-nuclear

A

Connective tissue disease (includes anti-dsDNA)

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13
Q

Anti-mitochondrial

A

Primary Biliary Cirrhosis

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14
Q

anti-PCD

A

Esp SCLC

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15
Q

anti-CCP

A

Rheumatoid arhtritis

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16
Q

Anti-Acetylcholine receptor

A

Myasthenia gravis

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17
Q

anti-TTG

A

Coeliac

18
Q

Anti-endomysial antibody

A

Coeliac, Dermatitis Herpetiformis

19
Q

anti-smooth muscle antibodies

A

Autoimmune hepatitis

20
Q

cANCA

A

Wegener’s granulomatosis

21
Q

pANCA - name 2

A
  1. Churg Strauss

2. Microscopic Polyangitis

22
Q

anti-GBM

A

Goodpasture’s

23
Q

Anti-intrinsic factor

A

Pernicious anaemia

24
Q

anti-sm antibody

A

SLE

25
Q

anti-phospholipid antibody

A

anti-phospholipid syndrome…

26
Q

anti-cardiolipin antibody

A

Anti-phospholipid syndrome

27
Q

Heterophiles antibody

A

Infectious mononucleosis

28
Q

Anti-microsomal antibody

A

Hashimoto’s thyroiditis

29
Q

Anti-TPO antibody

A

Hashimoto’s thyroiditis

30
Q

TSH receptor antibody

A

Grave’s disease

31
Q

Anti-Jo1 antibody

A

Dermatomyositis

32
Q

DNA topoisomerase I antibody

A

Diffuse scleroderma

33
Q

Anti-centromere antibody

A

CREST syndrome

34
Q

anti-ribonucleoprotein antibody

A

Mixed CTD

SLE

35
Q

Anti-platelet antibody

A

ITP

36
Q

antibodies vs GpIIb-IIIa

A

autoimmune thrombocytopenia purpura

37
Q

Cells important in T1DM

A

CD8+ T cells attack beta cells

38
Q

What happens in sensitisation (before full blown anaphylaxis)

A

Ag recognised by CD4 + Th2 cells and they release IL4 and IL13
This stimulates B cells to make IgE

39
Q

Multiple sclerosis - important antigens?

A

Myelin basic protein + proteolipid protein

40
Q

Polyarteritis nodosa is associated with which virus in 30% of cases

A

Hep B

41
Q

Patch testing

A

Contact dermatitis

42
Q

Latex fixation test

A

Rheumatoid factor