Microbio - antivirals

Question 1

Acyclovir - which herpes virus is this drug completely useless for and why?

Answer 1

CMV - this virus doesn’t use thymidine kinase

Question 2

Antiviral for treatment against CMV?

Answer 2

Ganciclovir

Question 3

Effects of CMV infection?

Answer 3

RCHEP
Retinitis
Colitis
Hepatitis
Encephalitis
Pneumonitis

Question 4

Histological finding of CMV infected cells?

Answer 4

Owls eye inclusion

Question 5

Major side effect of Ganciclovir?

Answer 5

Bone marrow suppression

Question 6

Pyrophosphate analogue?

Answer 6

Foscarnet

Question 7

Nucleoside phosphonate?

Answer 7

Cidofovir

Question 8

Management of HSV encephalitis?

Answer 8

EMPIRICAL = IV ACYCLOVIR FOR 21 DAYS

Question 9

3 drugs used to treat HSV infection?

Answer 9

Act V Fast
Acyclovir
Valaciclovir
Famciclovir

Question 10

If a patient undergoing BMT is infected with CMV, what are the 1st –> 3rd line antivirals used?

Answer 10

1) Ganciclovir
2) Foscarnet (or Gan + fos combo)
3) Cidofovir

Question 11

Treatment of HBV is dependent on 2 factors. what are they?

Answer 11

1) Serum HBV DNA levels

2) Serum aminotransferase levels

Question 12

Lymphoproliferative disease is associated with which viral infection? How is it treated?

Answer 12

EBV

Rituximab

Question 13

Tx of BK virus infection?

Answer 13

Cidofovir

Question 14

Infection with BK virus - 2 clinical manifestations?

Answer 14

Haemorrhage cystitis + ureteric stenosis

Question 15

Preferred 1st line treatment choice for HBV infection?

Answer 15

Entacavir
+ peg-IFNalpha2a
+ tenofovir

Question 16

Treatment of RSV?

Answer 16

Ribavirin

Question 17

Preventative treatment vs RSV?

Answer 17

Pavilizumab

Question 18

In whom is influenza tx indicated?

Answer 18

Patients requiring ADMISSION for flu