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Question 1

Systemic vasculitis of small and medium-sied arteries that presents with involvement of URI (sinusitis, nasal obstruction, epistaxis, otitis), lungs (hemoptysis), and kidneys (rapidly progressing glomerulonephritis). Presence of cANCA is typical.

Answer 1

Granulomatosis with polyangitis (wegener’s)

Question 2

Autoimmune disorder that presents with proximal muscle weakness and skin involvement including violaceous discoloration of the upper eye lids (heliotrope rash), and a raised, violaceous, scaling eruption on the knuckles (Gottron’s sign). CPK levels are typically elevated.

Answer 2

Dermatomyositis

Question 3

Young woman w/ malar rash, photosensitivity, malaise, anorexia, arthralgias

Answer 3

SLE

Question 4

Middle-aged pt with fever, malaise, anorexia, and lymph node enlargement. Lymph node biopsy reveals atypical lymphocytes

Answer 4

Non-Hodgkin lymphoma