Random 2a Flashcards

1
Q

Causes of microcytic anaemia?

A

TAILS
Thalassaemia, anaemia of chronic disease, iron deficiency, lead poisoning, sideroblastic anaemia (X-linked)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

What MCV is classified as microcytic anaemia?

A

<80 femtolitres

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

What MCV is classified as normocytic anaemia?

A

80-100 femtolitres

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

What MCV is classified as macrocytic anaemia?

A

> 100 femtolitres

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Causes of normocytic anaemia?

A

[3x As, 2x Hs]

  • Acute blood loss
  • Haemolytic anaemia - i.e. sickle cell disease
  • Anaemia of chronic disease
  • Aplastic anaemia - temp. stopped RBC production (bone marrow disorder)
  • Hypothyroidism
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Causes of macrocytic anaemia?

A
  • MEGALOBLASTIC (B12 deficiency + folate deficiency)
  • NORMOBLASTIC (alcohol abuse, drugs like MTX, liver disease or reticulocytosis)
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Direct Coombs test positive?

A

Autoimmune haemolytic anaemia(not in other types of haemolytic anaemia) - can either be warm AIHA or cold AIHA

Warm AIHA is more common

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

What anaemia can prosthetic valves cause?

A

Turbulent flow around the prosthetic valve = shearing of RBCs.
The valve churns up the cells, and they break down.

=> normocytic haemolytic anaemia

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Key findings in G6PD deficiency?

A

X-linked recessive (mainly males)

Acute episodes of haemolytic anaemia; triggered byinfections,drugs(i.e. anti-malarials) orfava (broad) beans.

⇒ jaundice, anaemia, splenomegaly
=> Heinz bodies on blood film

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

What is pernicious anaemia?

A

Autoantibodies against parietal cells or intrinsic factor.
=> lack absorption of vit B12

Presents with peripheral neuropathy & megaloblastic macrocytic anaemia

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

What to treat first when we have both B12 and folate deficiency?

A

It is essential to treat theB12 deficiency first, before correcting the folate deficiency.

Giving patientsfolic acid when they have aB12 deficiencycan lead tosubacute combined degeneration of the cord, with demyelination in the spinal cord and severe neurological problems.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Treatment for polycystic kidney disease?

A
  • Tolvaptan (vasopressin receptor antagonist)
  • Antihypertensives (ACE inhibitors)
  • Analgesia
  • Antibiotics for infections (e.g., UTIs or cyst infections)
  • Drainageof symptomatic can be performed by aspiration or surgery
  • Dialysisfor end-stage renal failure
  • Renal transplantfor end-stage renal failure
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Chlamydia treatment?

A

First line: doxycycline 100mg twice a day for 7 days

In pregnancy + breastfeeding:
Azithromycin 1g stat, then 500mg OD for 2 days

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Gonorrhoea treatment?

A
  • IM ceftriaxone1g - if sensitivities are NOT known
  • ORAL ciprofloxacin500mg - if sensitivities ARE known

=> TEST OF CURE!! with NAAT testing if they are asymptomatic, or cultures if symptomatic

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Syphilis treatment?

A

IMdose ofbenzathine benzylpenicillin

Ceftriaxone, amoxicillin and doxycycline are alternatives.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

What cancer metastases can cause “cannonball metastases” in the lungs?

A

Metastatic renal cell carcinoma.
These appear as clearly-defined circular opacities scattered throughout the lung fields on a chest x-ray.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

A 65 year old male reports significant weight loss as well severe pain in his right loin over the last 4 months which is abnormal for him. He is afrebrile but reports visible clots in his urine. CXR reveal cannon ball cancer metastases in his lungs. What genetic condition predisposes him the most to developing his primary cancer?

A

Primary cancer - renal cell carcinoma
Genetic condition - Von-Hippel Lindau syndrome

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

UTI treatment in pregnancy?

A
  • Cefalexin
  • Nitrofurantoin (avoid in the third trimester)
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

Why should trimethoprim be avoided in pregnancy?

A

Folate antagonist. Folate is essential in early pregnancy for normal development. Trimethoprim in early pregnancy can causecongenital malformations, particularlyneural tube defects(spina bifida)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

UTI treatment for lower UTI in women?

A

Women = uncomplicated
3 days of oral trimethoprim or nitrofurantoin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
21
Q

UTI treatment for lower UTI in men?

A

Men = complicated
7 days - oral trimethoprim or nitrofurantoin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
22
Q

UTI treatment for upper UTI? men, vs pregnant women?

A

1st line - cefalexin + co-amoxiclav (7-10 days)

Pregnancy - cefalexin is first-line oral, and cefuroxime is first-line IV.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
23
Q

Secondary prevention for stable angina?

A

4x As
- Aspirin (anti-platelet)
- Atenolol (b blocker)
- Atorvostatin
- ACE inhibitor (ramipril)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
24
Q

Interventions for late stage stable angina?

A
  • PCI - percutaneous coronary intervention - insert balloon, then leave stent in place (through femoral or brachial artery)
  • CABG - coronary artery bypass graft - for really severely stenosed coronary arteries - take graft pain from leg, use it to bypass the stenosis in the coronary artery.
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
25
Location of two scars from CABG?
- Midline sternotomy - Scar on inner calf (harvest the great saphenous vein)
26
Investigations for angina?
- CT coronary angiography (gold standard) - ECG - TFTs??
27
Two types of left-sided heart failure?
- Systolic - reduced ejection fraction (reduced contraction) - Diastolic - preserved ejection fraction (stiff muscle, so cannot relax)
28
Cor pulmonale?
Right-sided heart failure caused by respiratory disease, ie: - COPD (most common cause) - Pulmonary embolism - Interstitial lung disease - Cystic fibrosis - Primary pulmonary hypertension
29
Medical management for chronic heart failure?
ABAL: ACE inhibitor Beta-blocker (bisprolol) Aldosterone antagonist (spironolactone) Loop diuretic (furosemide)
30
Features of atrial stenosis?
- ejection systolic murmur (crescendo decrescendo|) - narrow pulse pressure - slow rising carotid pulse
31
Features of atrial regurgitation?
- diastolic, soft murmur - wide pulse pressure - collapsing pulse (water hammer pulse) - austin flint murmur
32
Features of mitral stenosis?
Loud S1 Mid-diastolic murmur => RHEUMATIC FEVER
33
Features of mitral regurgitation?
Pansystolic high pitched murmur => congestive HF => oedema
34
Surgical interventions for aortic aneurysm?
- EVAR - endovascular aortic repair - open surgery (preferred by NICE)
35
Definition of abdominal aortic aneurysm? AAA
Dilation of abdominal aorta >3cm Degradation of all 3 layers of the vessels (intima, media and adventitia).
36
True AAA vs psuedo (false) aneurysm?
Degradation of all 3 aortic layers is referred to as a true aneurysm, whilst degradation of less than 3 is a pseudoaneurysm
37
Definition of aortic dissection?
Where the blood enters between the intima and media layers of the aorta
38
Risk factors for aortic aneurysm + aortic dissection?
- Marfan syndrome and other connective tissue disorders - Men - Increased age - Smoking - Hypertension - Family history - Existing cardiovascular disease
39
Management for aortic aneurysm over 5.5cm dilation?
Elective surgery to prevent rupture: - open surgery - EVAR (endovascular aortic repair)
40
Management for RUPTURED aortic aneurysm? (+ define)
Aneurysm rupture = tear of all aortic wall layers (more severe than aortic dissection, which is just inner wall) - ABCDE - Fluid resuscitaiton - URGENT SURGICAL REPAIR (open surgery preferred) - repair with graft
41
Presentation of ruptured THORACIC aortic aneurysm?
- severe chest pain - haemodynamic instability (hypotension + tachycardia) - collapse - death - Cardiac tamponade (due to bleeding into pericardial cavity) - Haemoptysis (bleed into airways) - Haematemesis (bleed into oesophagus)
42
Monitoring requirments for AAA?
<3 (normal- not AAA) 3-4.4 cm = yearly 4.5-5.4cm = 3 monthly >5.5cm (elective surgery)
43
Cullen's sign and Grey Turners? where is this seen?
- Rupture of an aortic aneurysm - Haemorrhagic pancreatitis (severe) - Ruptured ectopic pregnancy
44
Define: aortic dissection
Tear in the innermost layer of aortic wall (intima). Blood collects between intima and media layers => forms an intramural 'false lumen'
45
Most common site for aortic dissection?
Right lateral area of ascending aorta This is area of highest pressure
46
Management of aortic dissection? (type A vs type B)
- MORPHINE FOR PAIN - IV LABETOLOL (to reduce tachycardia) Type A - (first part of asc aorta) = surgical - aortic graft (EVAR) Type B - (descending aorta) = normally conservative management with BP control - may also need EVAR
47
Complications of aortic dissection?
- Cardiac tamponade - Myocardial infarction - Stroke - Paraplegia (motor or sensory impairment in the legs) - Aortic valve regurgitation - Death
48
ECG changes in pericarditis?
- Saddle-shaped ST-elevation - PR depression - No reciprocal ST depression
49
Investigations in pericarditis?
- ECG - Echo - Bloods - Inflamm markers (high ESR, CRP, WCC)
50
Management of pericarditis?
- NSAIDs - Colchicine (used longer term, 3 mnths, to reduce risk of recurrence) - Pericardiocentesis may be required to remove fluid from around the heart if there is a significant pericardial effusion or tamponade.
51
Diagnosis of peripheral vasc disease? (investigations)
- ABPI (ankle-brachial pressure index) - <0.9 - GOLD STANDARD = CT angiography (CT or MRI) - Duplex doppler ultrasound imaging (speed and volume of blood flow) - Buerger's test - patient lies flat, raise legs to 45 degree angle for 1 min. Positive result if legs goes pallor and then re-perfuses when dropped.
52
Presentation of peripheral vascular disease?
- 6x Ps - Low ABPI (<0.9) - Leg ulcers - Xanthomata (yellow cholesterol deposits in skin)
53
What are the 6 Ps of acute limb-threatening ischaemia?
Pulseless Pallor Pain Perishingly cold Paralysis Paraesthesia
54
Treatment - for intermittent claudication
- Graded-exercise therapy’, diet control and smoking cessation. - STATINS - ANTI-PLATELETS - clopidogrel - Naftidrofuryl oxalate (5-HT2 receptor antagonist that acts as a peripheral vasodilator) - Endovascular angioplasty with stenting - Endartectomy - Bypass surgery
55
Treatment - for acute limb-threatening ischaemia?
THROMBUS = SURGICAL EMERGENCY - revascularisation is needed within 4-6 hours or else amputation risk is increased. - Endovascular thrombolysis - use catheter and insert thrombolysis directly into the clot - Endovascular thrombectomy - use catheter to remove thrombus - Surgical thrombectomy - cut open vessel to remove thrombus - Endartectomy - Bypass surgery - Amputation
56
Tetralogy of fallot?
- VSD - Overriding aorta - lies towwards RHS, meaning deoxy blood can go through VSD and enter aorta! - Pulmonary valve stenosis (encourages blood to flow across VSD instead) => right ventricle hypertrophy => right to left shunt = cyanosis!
57
Eisenmenger Syndrome?
When there is a VSD, blood typically flows from left to right = therefore no cyanosis occurs. = overtime this leads to right heart overload = RV hypertrophy = higher pressures in RV than LV = shunt swaps to become RIGHT TO LEFT SHUNT = NOW IS CYANOTIC (Eisenmenger Syndrome)
58
Beck's triad of acute pericarditis?
Hypotension Raised JVP Muffled heart sounds => sign of cardiac tamponade
59
Important differential for symptoms of meningism?
Subarachnoid haemorrhage
60
Community treatment of meningitis?
IM benzylpenicillin (in presence of non-blanching rash)
61
Prophylactic treatment for meningitis close contacts? time frame of contact?
Last 7 days Single dose of ciprofloxacin
62
Hospital treatment of bacterial meningitis?
ANTIBIOTIC + DEXAMETHASONE: <3 months - cefotaxime >3 months - ceftriaxone (3rd gen cephalosporins) Dexamethasone - to reduce risk of hearing loss or neurological damage
63
Kernig's test?
lying the patient on their back, flexing one hip and knee to 90 degrees and then slowly straightening the knee whilst keeping the hip flexed at 90 degrees. This creates a slight stretch in the meninges. Where there is meningitis it will produce spinal pain or resistance to movement.
64
Brudzinski's test?
lying the patient flat on their back and gently using your hands to lift their head and neck off the bed and flex their chin to their chest. In a positive test this causes the patient to involuntarily flex their hips and knees.
65
Difference between CSF lumbar puncture in viral vs bacterial meningitis?
Bacterial - yellow/cloudy (viral - clear) Bacterial - low glucose (bact. use up) Bacterial - high protein (bact. produce) WCC - high neutrophils (bacterial) vs high lymphocytes (viral)
66
What does purpuric non-blanching rash indicate?
DIC caused by meningococcal septicaemia (N.meningitidis has entered blood stream)
67
Why might we add amoxicillin on top of ceftriaxone in meningitis?
If there is a high risk of listeriosis (i.e. older age 73yo). AMOXICILLIN - to cover listeria
68
Murphy's sign? When is it positive?
Positive in acute cholecystitis Press in upper RQ Patient inhales deeply Gallbladder will move downwards; when it comes into contact with your hand the patient will STOP inhaling (due to acute pain)
69
Investigation for acute cholecystitis + findings?
Ultrasound - Thick-walled gallbladder - Stones in gallbladder - Fluid around the gallbladder
70
Investigation for acute cholangitis + findings?
71
Charcot's triad + which condition?
Acute cholangitis presents with Charcot’s triad: Right upper quadrant pain Fever Jaundice (raised bilirubin)
72
Management of acute cholangitis?
- IV ANTIBIOTICS (due to infection - risk of sepsis) - ERCP - to remove gallstones, or baloon dilatation or stents for strictures - Laparoscopic cholecystectomy (remove gallbladder) - once stable
73
Management of acute cholecystitis?
- IV ANTIBIOTICS - ERCP to remove gallstones if stuck in common bile duct - Laparoscopic Cholecystectomy (removal of the gallbladder) is usually be performed during the acute admission, within 72 hours of symptoms
74
Wilsons disease? typical patient + presentation?
Excess copper in all tissues, particularly in liver Typically younger patient - Kayser-fleischer rings (cornea) - Chronic hepatitis - leads to liver cirrhosis - Neurological symptoms - tremor, dysarthria (speech difficulties) and dystonia (abnormal muscle tone) + Parkinsonism (copper in basal ganglia) - Psychiatric symptoms - abnormal behaviour, depression, cognitive impairment and psychosis
75
Treatment for pruritis?
Cholestyramine (bile acid sequestrant)
76
What is hepatic encephalopathy + exam finding?
Reversible syndrome in advanced liver dysfunction. Results from accumulation of neurotoxic substances in the brain = **AMMONIA** ASTERIXIS (sign of grade 2/3 HE) - patient told to hold hand like stopping traffic, but it flaps down instead
77
Drug to treat hepatic encephalopathy?
Lactulose (first-line) - laxative to promote ammonia excretion Rifaximin - antibiotic
78
Epigastric pain radiating to the back?
Acute pancreatitis
79
AST:ALT ratio in NAFLD?
Higher ALT (reversed ratio) >0.8 indicates advanced fibrosis
80
AST:ALT ratio in ALD?
>1.5 (high AST!) (2:1 ratio)
81
Cushing’s reflex/triad?
Hypertension + bradycardia + irregular respirations This is the response to raised ICP - in extradural haemorrhage - in head injury etc
82
First line treatment for trigeminal neuralgia?
This is headache with trigeminal nerve distribution. - Carbamazepine (anti-spasmodic)
83
Hepatic encephalopathy?
Excess ammonia reversible syndrome COMPLICATION of advanced CIRRHOSIS ++ ASTERIXIS - hand flap (grade 2/3)
84
Treatment for hepatic encephalopathy?
IV lactulose (laxative) - to exrete excess ammonia Rifaximin - antibiotic (to reduce int. bacteria producing ammonia)
85
Child Pugh score use? components?
severity of cirrhosis **A** – **Albumin - **B** – **Bilirubin - **C** – **Clotting (INR) - **D** – **Dilation (ascites) - **E** – **Encephalopathy
86
Scan used in cirrhosis?
Transient Elastography (FibroScan) Used to assess the stiffness of the liver using high-frequency sound waves. It helps determine the degree of fibrosis (scarring) to test for liver cirrhosis.
87
Wernicke’s encephalopathy vs Korsakoff syndrome
Both caused by thiamine / VITAMIN B1 deficiency Wernicke's encephalopathy represents the "acute" phase of the disorder and Korsakoff's amnesic syndrome represents the disorder progressing to a "chronic" or long-lasting stage. ***Wernicke’s encephalopathy*** is a medical emergency with a high mortality rate.  ***Korsakoff syndrome*** is often irreversible and results in patients requiring full-time or institutional care.
88
Triad of symptoms in Wernicke’s encephalopathy?
Confusion Oculomotor disturbances (eye muscle paralysis) Ataxia (difficulties with coordinated movements)
89
Features of Korsakoff syndrome include?
Memory impairment (retrograde and anterograde) Behavioural changes
90
Causes of Wernicke’s encephalopathy?
Mainly EXCESS ALCOHOL But also: - Pancreatitis - Liver dysfunction - Vomiting / hyperemesis gravidarum - Starvation/fasting - Cancer - AIDS
91
Medication for motor neuron disease?
Riluzole - can slow disease progression & extend survival by several MONTHS in ALS
92
Investigations for Guillian Barre syndrome? (+ their findings)
- Nerve conduction studies (reduced signal through nerves) - Lumbar puncture for cerebrospinal fluid (showing raised protein with a normal cell count and glucose)
93
Scoring system for GBS?
Brighton criteria: - bilateral weakness of limbs - decreased tendon reflexes - absence of alternative diagnosis - CSF cell count normal - CSF raised protein - nerve conduction studies - show reduced conduction
94
Treatment for GBS?
- IV IG (immunoglobulins) - 1st line - Plasmapheresis - 2nd line - VTE prophylaxis - to prevent pulmonary embolism (leading cause of death, as muscle weakness causes immobility)
95
Presentation of GBS?
Sympton onset 4 weeks after gastroenteritis - Symmetrical ascending weakness - Reduced reflexes - Peripheral loss of sensation - Neuropathic pain - May progress to the cranial nerves and cause facial weakness. - Autonomic dysfunction can lead to urinary retention, ileus or heart arrhythmias.
96
Causes of GBS?
COMMON - Camplyobacter jejuna - CMV - EBV
97
Antibodies in GBS?
Anti-GM1 antibodies = destruction of Schwann cells (PNS)
98
Diagnostic criteria for neurofibromatosis type 1?
CRABBING: - C – Café-au-lait spots (more than 15mm diameter is significant in adults) - R – Relative with NF1 - A – Axillary or inguinal freckling - BB – Bony dysplasia, such as Bowing of a long bone or sphenoid wing dysplasia - I – Iris hamartomas (*Lisch nodules*) - yellow-brown spots on the iris - N – Neurofibromas (skin-coloured, raised nodules or papules with a smooth, regular surface)
99
What tumours are associated with neurofibromatosis type 2?
Acoustic neuromas, which are tumours of the auditory nerve that innervates the inner ear.
100
Causes of peripheral neuropathy?
ABCDE (+ Charcot-Marie-Tooth syndrome) - A – Alcohol - B – B12 deficiency - C – Cancer (myeloma) and Chronic kidney disease - D – Diabetes and Drugs (isoniazid, amiodarone, leflunomide and cisplatin) - E – Every vasculitis
101
Presentation of Charcot-Marie-Tooth disease?
Autosomal dominant Typically at 10 years old, but may be delayed until 40+ years old - High foot arches (pes caves) - Distal muscle wasting (inverted champagne bottle legs) - Loss of ankle dorsiflexion = FOOT DROP! - Reduced tendon reflexes - Reduced muscle tone - Peripheral sensory loss
102
Physiology of Lambert-Eaton myasthenic syndrome?
Autoimmune condition affecting the NMJ, similar to myasthenia gravis. Antibodies against voltage-gated calcium channels (in presynaptic membrane of NMJ) VGCCs destroyed = less Ach released into the synapse, resulting in a weaker signal and reduced muscle contraction.
103
Disease associated with Lambert-Eaton myasthenic syndrome?
Paraneoplastic syndrome occuring alongside small cell lung cancer (but can also present as a primary AI disorder without SCLC)
104
Treatment for Lambert-Eaton myasthenic syndrome?
- Amifampridine - Pyridostigmine (cholinesterase inhibitor) - Immunosuppressants (prednisolone or azathioprine) - IV immunoglobulins, or plasmapheresis
105
Presentation of Lambert-Eaton myasthenic syndrome?
- Proximal muscle weakness difficulty standing from a seat. - Autonomic dysfunction - dry mouth, blurred vision, impotence & dizziness - Reduced or absent tendon reflexes
106
How to differentiate Lambert-Eaton + Myasthenia Gravis based on symptoms after a period of muscle contraction?
In Lambert-Eaton, signs and symptoms will improve after a period of muscle contraction (i..e improved muscle strength after use, or present tendon reflexes). Whereas in MG, after muscle usage, the symptoms get progressively worse (fatigued) - symptoms improve with rest!
107
Which tumours are linked to MG?
Strong link with thymomas (thymus gland tumours). 10-20% of patients with MG have a thymoma. 30% of patients with a thymoma develop MG.
108
Clinical exam to assess muscle fatiguebility in MG?
- ask patient to repeatedly blink to cause ptosis worsening - ask to look upwards - worsens diplopia when eyes moved side to side OR - repeatedly abduct arm to the side (up and down) 20 times = leads to unilateral weakness
109
What is the edrophonium test? (used in MG)
Block cholinesterase enzymes that break down Ach = raised levels of Ach = brief relief of muscle weakness
110
Antibodies present in MG?
Ach- receptor antibodies (85%)
111
Treatments for MG?
- Pyridostigmine/ neostigmine - acetylcholinesterase inhibitors - Immunosuppression (prednisolone or azathioprine) suppresses Ab production - Thymectomy can improve symptoms, even in patients without a thymoma - Rituximab (mAb against B cells) - considered where other treatments fail
112
Treatment of myasthenic crisis?
Acute worsenin gof symptoms, might be triggered by resp. tract infection => RESP FAILURE - BIPAP / intubation with ventilation - IV immunoglobulins or plasmapheresis
113
Risk factors/associations for subarachnoid haemorrhage?
- Autosomal dominant polycystic kidney disease ⇒ predisposes to berry aneurysms - Connective tissue disorders (Marfan or Ehlers-Danlos) - Aged 45 to 70 - Women - Black ethnic origin - Family history - Cocaine use - Sickle cell anaemia - Neurofibromatosis
114
CSF findings in subarachnoid haemorrhage?
- raised RBC count in CSF - xanthochromia - yellow colour from bilirubin in CSF
115
Surgical options for extradural and subdural haemorrhages?
- Craniotomy (open surgery by removing a section of the skull) - Burr holes (small holes drilled in the skull to drain the blood)
116
Treatment options for subarachnoid haemorrhage?
- Nimodipine (CCB) - prevents vasospasm (a common complication that causes brain ischaemia) SURGICAL: Treat aneurysms with endovascular coiling or neurosurgical clipping.
117
Presentation of subarachnoid haemorrhage?
THUNDERCLAP HEACHAE, SUDDEN ONSET DURING STRENUOUS ACTIVITY - Meningism - neck stiffness, photophobia, vomiting) - Neurological symptoms (visual changes, dysphasia, focal weakness, seizures and reduced consciousness) - Third nerve palsy - oculomotor - compressed by aneurysm on posterior communicating artery
118
Bell's palsy?
Idiopathic - no apparent cause. Presents with unilateral lower motor neurone facial nerve palsy. Most patients fully recover over several weeks, but recovery may take up to 12 months. - Forehead affected (unilateral) - Ptosis (unilateral) - Loss of nasolabial fold (unilateral)
119
Management of TIA?
- Aspirin 300mg daily (started immediately) - Referral for specialist assessment within 24 hours (within 7 days if more than 7 days since the episode) - Diffusion-weighted MRI scan
120
Management of stroke?
- Exclude hypoglycaemia - Immediate CT brain to exclude haemorrhage - Aspirin 300mg daily for two weeks (started after haemorrhage is excluded with a CT) - Admission to a specialist stroke centre: - Thrombolysis with alteplase (within 4hrs) - Thrombectomy - surgery to remove clot within 24hrs (with confirmed blockage of proximal anterior/posterior circulation)
121
2x investigations for the 2 main underlying causes of stroke or TIA?
- Carotid imaging (e.g., carotid ultrasound, or CT or MRI angiogram) - ECG (to look for atrial fibrillation)
122
Surgical options for confirmed carotid artery stenosis causing stroke/TIA?
Considered where there is significant carotid artery stenosis. The options are: - Carotid endarterectomy (recommended in the NICE guidelines) - Angioplasty and stenting
123
Secondary prevention of stroke?
- Clopidogrel 75mg OD (alternatively aspirin plus dipyridamole) - Atorvastatin 20-80mg (usually delayed at least 48 hours) - Blood pressure and diabetes control - Addressing modifiable risk factors (e.g., smoking, obesity and exercise)
124
Brown-seqard ipsilateral vs contralateral losses?
=> ipsilateral loss of motor function (corticospinal tract) => ipsilateral loss of sensory info about fine touch, vibration, proprioception and pressure (DCML tract) => contralateral loss of pain, temp and crude touch (spinothalamic)
125
Components of GCS score?
MOTOR RESPONSE /6 VERBAL RESPONSE /5 EYE OPENING RESPONSE /4
126
Muscles affected by motor symptoms of carpal tunnel syndrome?
Thenar muscles at base of thumb - Weakness of thumb movements - Weakness of grip strength - Difficulty with fine movements involving the thumb - Wasting of the thenar muscles (muscle atrophy)
127
Distribution of sensory symptoms of carpal tunnel syndrome?
Sensory symptoms in the distribution of the palmar digital cutaneous branch of the  **median nerve**, affecting the palmar aspects and full fingertips of the: - Thumb - Index and middle finger - The lateral half of ring finger **Sensory symptoms** include: - Numbness - Paraesthesia (pins and needles or tingling) - Burning sensation - Pain (OFTEN WORSE AT NIGHT)
128
Diagnosis of carpal tunnel? 2x
- Kamath and Stothard carpal tunnel questionnaire (CTQ) - a high score may replace the need for nerve conduction studies to confirm the diagnosis. - Nerve conduction studies: a small electrical current is applied by an electrode to the median nerve on one side of the carpal tunnel. Recording electrodes over the median nerve on the other side of the carpal tunnel record the electrical current that reaches them. This demonstrates how well signals are passing through the carpal tunnel along the median nerve.
129
Improvement of tremor with alcohol - PD or essential tremor?
Essential tremor improves with alcohol
130
Parkinsonism and autonomic dysfunction?
Multiple System Atrophy: Degeneration of the basal ganglia leads to a Parkinson’s presentation. Degeneration in other areas leads to autonomic dysfunction (causing postural hypotension, constipation, abnormal sweating and sexual dysfunction) and cerebellar dysfunction (causing ataxia).
131
Parkinsonism with memory issues?
Lewy body dementia Type of dementia associated with features of Parkinsonism. It causes a progressive cognitive decline. There are associated symptoms of visual hallucinations, delusions, REM sleep disorders and fluctuating consciousness.
132
First line treatment for trigeminal neuralgia?
Carbamazapine TN - intense facial pain that can last for a few seconds to a few hours. The pain is commonly caused by light touch and can occur spontaneously as well.
133
Treatment for migraine? (2 categories!)
Abortive treatment: - Oral triptan (sumatriptan) + an NSAID or paracetamol - Anti-emetic (metoclopramide or prochlorperazine) - Opiates are not used to treat migraines and may make the condition worse. Preventative treatment (if 4-5 attacks a month or interfering with QOL) - Propranolol OR topiramate (anti-epileptic; teratogenic) or amitriptyline (tricyclic antidepressant)
134
Treatment for status epilepticus?
- Benzodiazepine (diazepam/midazolam/lorazepam) - repeated after 5-10 minutes if the seizure continues - After two doses of benzodiazepine = IV levetiracetam, phenytoin or sodium valproate - Third-line options are phenobarbital or general anaesthesia
135
Cluster headache - treatment + prophylaxis?
Treatment: subcutaneous triptans (i.e. sumatriptan) Prophylaxis: verapamil (CCB) (C for CLUSTER + CCB)
136
Drugs in AD?
- Acetylcholinesterase inhibitors (rivastigmine + donepezil) - MEMANTINE = NMDA receptor agonist
137
Most likely type of bleed? - head injury with loss of consciousness, followed by lucid period
Extradural haemorrhage (LEMON SHAPE)
138
Most likely type of bleed? - head injury with loss of consciousness, followed by gradual deteroriation
Chronic subdural haemorrhage
139
Investigations + management of DVT?
- Wells score - D-dimer - Doppler ultrasound - CT pulmonary angiogram OR ventilation-perfusion scan - to diagnose PE = 3 months DOAC (or LMWH in pregnancy)
140
Investigations for peripheral arterial disease?
- ABPI (ankle-brachial pressure index) <0.9 - Duplex Doppler ultrasound - Buerger’s test - lie patient flat, raise their leg 45º angle for 1 minute. Positive result is if the leg goes pallor and then becomes perfused when restored to normal position. The more severe the ischaemia, the lower the angle is needed to induce pallor. (see photo in SIGNS)
141
Signs of peripheral arterial disease?
- 6Ps - ABPI <0.9 Leg ulcers Xanthomata (yellow cholesterol deposits on the skin) - Positive Buerger's test - if leg goes pale when lifted (in the second part of the test, the leg first goes blue, then turns red)
142
Treatment options for peripheral arterial disease (intermittment claudication + critical limb ischaemia)
- ‘Graded-exercise therapy’, diet control and smoking cessation. - STATINS - atorvastatin** 80mg - ANTI-PLATELETS - clopidogrel 75mg OD - Naftidrofuryl oxalate (5-HT2 receptor antagonist that acts as a peripheral vasodilator) - Endovascular angioplasty with stenting. - Endarterectomy – cutting vessel open and removing the atheromatous plaque. - Bypass surgery – using a graft to bypass the blockage
143
Treatment options for peripheral arterial disease? (acute limb-threatening ischaemia)
THROMBUS!! - Surgical emergency, revascularisation is needed within 4-6 hours or else amputation risk is increased. - Endovascular thrombolysis - use catheter and insert thrombolysis directly into the clot - Endovascular thrombectomy - use catheter to remove thrombus - Surgical thrombectomy - cut open vessel to remove thrombus - Endartectomy - Bypass surgery - Amputation
144
6Ps of acute limb-threatneing ischaemia?
Pulselessness Pallor Pain Perishingly cold Paralysis Parasthesia
145
Shockable rhythms?
Ventricular fibrillation Ventricular tachycardia
146
Non-shockable rhythms?
Asystole Pulseless electrical activity (PEA)
147
Common causes of AF?
SMITH - Sepsis - Mitral valve path (sten/regurg) - Ischaemic HD - Thyrotoxicosis (hyperthyroidism) - Hypertension
148
Causes of secondary hypertension?
Secondary HTN = identifiable cause = ROPED: - Renal artery stenosis - Obesity - Pregnancy - Endocrine (Conn's) - Drugs (alcohol, steroids, oestrogen, NSAIDs)
149
Common side effects of statins?
Myalgia (muscle pain)
150
Signs and symptoms of heart failure?
- Ascites - Extertional dyspnoea - Cough - frothy pink/white sputum - Orthopnoea - breathlessness when lying flat, relieved by sitting or standing (ask how many pillows they use) - Paroxysmal nocturnal dyspnoea - suddenly waking at night with a severe attack of shortness of breath, cough and wheeze. - Peripheral oedema (ankle swelling) - Fatigue - Tachycardia - Displaced apex beat - Raised JVP - jugular venous pressure - Added heart sounds and murmurs - i.e. 3rd heart sound - Hepatomegaly, especially if pulsatile and tender
151
Medical treatment of heart failure?
ABAL AceI Beta blocker Aldosterone antagonist (spironolactone/eplerenone) Loop diuretic (furosemide)
152
Signs of heart failure on chest x-ray?
**ABCDE** - - Alveolar oedema - Kerley B lines (interstitial oedema) - Cardiomegaly - Dilated prominent upper lobe vessels - Pleural effusions (blunted costophrenic angle)
153
Which cell line is proliferating in primary myelofibrosis?
Haematopoietic stem cells => bone marrow fibrosis => affects production of blood cells
154
Which cell line is proliferating in polycythaemia vera?
Erythroid cells => excess RBCs (high Hb)
155
Which cell line is proliferating in essential thrombocythaemia?
Megakaryocytes => high platelet count
156
Causes of myelofibrosis?
Myelofibrosis can result from primary myelofibrosis, polycythaemia vera or essential thrombocythaemia.
157
Blood film finding in myelofibrosis?
- Teardrop-shaped red blood cells )(poikilocytes) - Anisocytosis (varying sizes of RBCs) - Blasts (immature RBC + WCCS)
158
Bone marrow biopsy findings in myelofibrosis?
Bone marrow biopsy is required to confirm the diagnosis.  Bone marrow aspiration may be “dry” with myelofibrosis, as the bone marrow has turned to scar tissue.
159
Treatment for primary myelofibrosis?
- Chemotherapy (hydroxycarbamide) - JAK2 inhibitor (ruxolitinib) - Allogeneic stem cell transplantation (risky but potentially curative)
160
Treatment for polycythaemia vera?
- Venesection (excess RBCs) - Aspirin (reduce thrombus risk) - Chemotherapy (hydroxycarbamide)
161
Treatment for essential thrombocythaemia?
- Anagrelide (platelet-lowering agent) - Aspirin (reduce thrombus risk) - Chemotherapy (hydroxycarbamide)
162
Presentation of polycythaemia vera?
- Ruddy complexion (red face) - Conjunctival plethora (the opposite of conjunctival pallor) - Splenomegaly - Hypertension
163
Which factor is deficient in Haemophilia A?
Factor 8
164
Which factor is deficient in Haemophilia B?
Factor 9
165
Inheritance pattern of haemophilia?
X-linked recessive
166
Cause of swollen/painful joint in haemophilia?
Spontaneous bleeding into joints (haemarthrosis) such as the ankle, knee or elbow can lead to joint damage and deformity.
167
Signs of thalassaemia major?
- Frontal bossing (prominent forehead) - Enlarged maxilla (prominent cheekbones) - Depressed nasal bridge (flat nose) - Protruding upper teeth Beta thalassaemia major = homozygous 2x deletion genes (no functioning beta-globin genes). => severe anaemia => bone marrow under so much strain to produce extra RBCs to compensate for the chronic anaemia that it expands enough to increase the risk of fractures and change the patient’s appearance ^
168
Mutations of thalassaemia + chromosome?
- Alpha thalassaemia - chromosome 16 - abnormal a-globin gene - Beta thalassaemia - chromosome 11 - abnormal B-globin gene
169
Mutation of sickle cell anaemia + chromosome?
Abnormal haemoglobin. Autosomal recessive; mutation in B-globulin gene on chromosome 11 ⇒ HbS
170
Complications of sickle cell anaemia?
- Vaso-occlusive crisis - Priapism - persistent erection - Splenic sequestration crisis - Aplastic crisis (parvovirus B19 infection - temp. absence of creation of new RBCs - often resolves in 1 week) - Acute chest syndrome: vessels supplying lungs clogged with RBCs - hypoxia causes further HbS polymerisation - reduces blood flow further - causes more lung damage
171
2x tests for immune response for TB?
- Mantoux test (tuberculin skin test) - Interferon-gamma release assay (IGRA) Blood sample is mixed with TB antigens = if they have previously been sensitised, WBCs will release IFG.
172
Investigations for TB?
- Chest x-ray - Cultures of deep sputum samples
173
Chest x-ray findings in TB?
- Primary TB - patchy consolidation, pleural effusions and hilar lymphadenopathy. - Reactivated TB -patchy or nodular consolidation with cavitation (gas-filled spaces), typically in the upper zones. - Disseminated miliary TB -appearance of millet seeds uniformly distributed across the lung fields.
174
Atypical pneumonia mnemonic?
“Legions of psittaci MCQs” - Legions – Legionella pneumophila. Can cause syndrome of inappropriate ADH (SIADH), resulting in hyponatraemia (low sodium). - Psittaci – Chlamydia psittaci From infected birds (parrots) - M – Mycoplasma pneumoniae - C – Chlamydophila pneumoniae In school age children. - Qs – Q fever (coxiella burnetii) Body fluids of animals = farmer
175
Signs of cystic fibrosis?
- Low weight or height on growth charts - Nasal polyps - Finger clubbing - Crackles and wheezes on auscultation - Abdominal distention
176
Lofgren’s Syndrome?
A specific acute clinical presentation of systemic sarcoidosis, consisting of: - polyarthralgia (joint pain in multiple joints) - erythema nodosum - bilateral hilar adenopathy
177
Investigations for sarcoidosis?
- Raised ACE - screening test - Raised calcium (hypercalcaemia) - Chest x-ray + high res CT - shows hilar lymphadenopathy
178
ECG findings for pulmonary embolism?
S1 Q3-T3 - S waves in lead I - Q waves in lead III - Inverted T waves in lead III
179
What is bronchiectasis?
Permanent dilation of the bronchi Sputum collects (STASIS) here due to the widened tubes ⇒ chronic cough ⇒ continuous sputum production ⇒ recurrent infections
180
Conditions that may lead to bronchiectasis?
- Cystic fibrosis - Idiopathic (no apparent cause) - Pneumonia - Whooping cough (pertussis) - Tuberculosis - Alpha-1-antitrypsin deficiency - Connective tissue disorders (e.g., rheumatoid arthritis) - Yellow nail syndrome
181
Chest x-ray signs of bronchiectasis?
- Tram track opacities (parallel markings of a side-view of the dilated airway) - Ring shadows (dilated airways seen end-on)
182
Diagnosis of bronchiectasis?
- High resolution CT chest(DIAGNOSTIC) - Chest x-ray - Sputum culture (for psuedomonas aeruginosa colonisation)
183
Exudative vs transudative pleural effusion?
- Exudative - high protein content (more than 30g/L) - Transudative - lower protein content (less than 30g/L)
184
Causes of exudative pleural effusion?
Related to inflammation = protein leaking out of tissues - Cancer (lung cancer + mesothelioma) - Infection (pneumonia + TB) - Rheumatoid arthritis
185
Causes of transudative pleural effusion?
- Cirrhosis - Congestive heart failure - Hypoalbuminaemia - Hypothyroidism - Meigs syndrome
186
What is meigs syndrome?
Triad of: - Benign ovarian tumour - Pleural effusion - Ascites
187
Signs of pleural effusion on chest x-ray?
- Blunting of the costophrenic angle - Fluid in the lung fissures - Larger effusions will have a meniscus (curving upwards where it meets the chest wall and mediastinum) - Tracheal and mediastinal deviation away from the effusion (in very large effusions)
188
What is empyema?
When a pleural effusion becomes infected. Pleural aspiration will show: = pus = low pH = low glucose (used up by the bacteria) = high LDH Treatment: - Chest drain - Antibiotics
189
Management of tension pneumothorax?
Insert a large bore cannula into the 2nd intercostal space in the midclavicular line. A chest drain is required for definitive management once the pressure is relieved with a cannula.
190
Presentation of croup?
- Increased work of breathing - Barking” cough, occurring in clusters of coughing episodes - Hoarse voice - Stridor (high-pitched inspiratory noise due to upper airway obstruction) - Low-grade fever
191
Treatment for otitis media?
- Amoxicillin for 5-7 days (first-line) - Clarithromycin (if penicillin allergic) - Erythromycin (in pregnant women allergic to penicillin)
192
Treatment for croup?
Dexamethasone
193
Management of epiglottitis?
EMERGENCY - skip examinations - Ensure airway is secure (prepare to intubate if needed) - IV antibiotics (ceftriaxone) - Steroids (dexamethasone)
194
Presentation of epiglottitis in a child?
- Tripod position, sat forward with a hand on each knee - Sore throat + stridor - Drooling - High fever - Difficulty or painful swallowing - Muffled voice - Scared and quiet child - Septic and unwell appearance
195
Signs of strep throat?
Caused by S.pyogenes (group A) Strep throat = another type of pharyngitis, can also cause: - Difficulty in swallowing - Red throat with white or grey patches - Swollen lymph nodes - Fever - Loss of appetite - Nausea - Unusual taste in the mouth - General malaise
196
Horner's syndrome?
Ptosis Miosis (constricted pupil) Facial anhidrosis (loss of sweating)
197
Alpha-1 antitrypsin deficiency?
Autosomal co-dominant genetic condition caused by low levels of alpha-1 antitrypsin. (this is a protease inhibitor = less inhibition of neutrophil elastase) - Liver disease (protein retention in liver) - Emphysema (lungs disease - damage to alveoli walls)
198
Enzyme affected in alpha-1 antitrypsin deficiency?
Alpha-1 antitrypsin offers protection by inhibiting the action of neutrophil elastase. - Neutrophil elastase breaks down elastic tissue in the lungs => bronchiectasis and emphysema - Alpha-1 antitrypsin is produced in the liver. An abnormal mutant version of the protein is made that gets trapped and builds up inside the liver cells (hepatocytes). = inflammation = fibrosis, cirrhosis + hepatocellular carcinoma
199
Hypertonic Saline Stimulation Test?
test for diabetes insipidus - co-peptin levels (high = confirms nephorgenic DI) - give hypertonic saline = stimulates ADH = measures co-peptin again: --> still low levels = cranial DI --> high levels = primary polydipsia
200
What conditions are associated with Wolfram syndrome?
Genetic condition causing diabetes insipidus, diabetes mellitus, optic atrophy and deafness.
201
Renin:aldosterone ratios in primary vs secondary hyperaldosteronism?
- PRIMARY (Conn's) = adrenal adenoma = high aldosterone, low renin - SECONDARY - low BP sensed by kidneys due to renal artery stenosis, HF etc = HIGH RENIN = high aldosterone
202
Causes of primary hyperaldosteronism?
- Adrenal adenoma - secreting aldosterone (Conn’s syndrome) - Bilateral adrenal hyperplasia (most common) - Familial hyperaldosteronism (rare)
203
Causes of secondary hyperaldosteronism?
- Renal artery stenosis (atherosclerotic narrowing of renal artery) - Heart failure - Liver cirrhosis and ascites
204
Two types of precocious puberty?
- True (central) - either idiopathic or CNS tumours - treat with GnRH superagonist (suppresses GnRH secretion) - Pseudo - tumours drive excess androgens or gonadotropins (not GnRH)
205
Two types of delayed puberty?
- PRIMARY - Hypergonadotrophic hypogonadism (lack of oest/test = neg feedback = high GnRH) - SECONDARY/TERTIARY - Hypogonadotrophic hypogonadism (low GnRH = no gonad stimulation)
206
Causes of hypergonadotrophic hypogonadism?
- Gonad trauma or mumps - Kleinfelters (47 XXY) - Turners (45 XO)
207
Causes of hypogonadotrophic hypogonadism?
- Damage to hypothalamus/pit gland - GH deficiency - Constitutional delay in growth and development - Kallman syndrome (failure of migration of GnRH neurons) - also associated with anosmia
208
Turner syndrome
45 XO Can cause delayed puberty (hypergonadotrophic hypogonadism)
209
Klinefelter's syndrome
47 XXY Can cause delayed puberty (hypergonadotrophic hypogonadism)
210
If the CT scan did not confirm subarachnoid haemorrhage, what would you do next to confirm? what would it show?
Lumbar puncture - CSF shows raised RBC count - CSF shows xanthochromia - yellow colour from bilirubin
211
Features of headache indicating tumour?
Worse on waking Worse on coughing Postural
212
Investigations for myasthenia gravis?
Antibodies (anti-Ach receptor + MuSK + LRP4) INDUCE MUSCLE FATIGUE (blink to cause ptosis OR abduct arm) Forced vital capacity (spirometry) - check strength of respiratory muscles CT/MRI - check for thymoma Edrophonium test - blocks cholinesterase enzymes that break down Ach = raised levels of Ach = brief relief of muscle weakness
213
Pre-hepatic jaundice?
Excessive RBC breakdown = liver cannot conjugate all of the bilirubin => excess unconjugated bilirubin causes: haemolysis (i.e. in sickle cell disease, G6PD deficiency, malaria, autoimmune haemolytic anaemia)
214
Hepatic jaundice?
Dysfunction of the hepatic cells - liver cannot conjugate bilirubin = results in conjugated + unconjugated bilirubin in the blood (’mixed picture’) Causes: hepatitis, ischaemia, neoplasm, congestive HF
215
Post-renal jaundice?
OBSTRUCTIVE - blocks flow of bile (gallstones, malignancy i.e pancreatic cancer or cholangiocarcinoma, cholangitis, strictures) Bilirubin not excreted, but has already been conjugated by liver = conjugated hyperbilirubinaemia
216
Type 4 hypersensitivity?
T1DM, Graves, MS T cell-mediated
217
Type 3 hypersensitivity?
RA, SLE, occupational lung disorders Ag-Ab DEPOSITION
218
Type 2 hypersensitivity?
Goodpasture's Ag-Ab FORMATION
219
Type 1 hypersensitivity?
Anaphylaxis IgE-mediated
220
Charcot’s neurological triad
Seen in MS - Nstagmus (plaques in nerves of eyes) - Dysarthria (plques in brainstem) - Intention tremor (plaques in motor pathways)
221
Pagets disease of bone?
Unknown cause Excessive bone turnover due to increased osteoclast and osteoblast activity. The excessive turnover is not coordinated, leading to patchy areas of high density (sclerosis) and low density (lysis)
222
Pagets disease PRESENTATION?
may be **asymptomatic** - Bone pain - Bone deformity - Fractures - Hearing loss
223
Pagets disease - xray findings?
- Bone enlargement and deformity - Osteoporosis circumscripta (well-defined osteolytic lesions) - Cotton wool appearance of the skull - V-shaped osteolytic defects in the long bones
224
Pagets disease BLOOD FINDING
Raised ALP (normal calcium + phosphate)
225
Management of Pagets disease?
Monitoring - check serum alkaline phosphatase (ALP) and review symptoms. Effective treatment should normalise the ALP and eliminate symptoms. First line: Bisphosphonates Other measures include: - Calcitonin - where bisphosphonates are unsuitable - NSAIDs for bone pain - Calcium and vitamin D supplementation, if necessary - Surgery is rarely required to treat fractures, severe deformities and arthritis
226
Cause of osteomalacia?
Soft bones Due to defective bone mineralisation Caused by VIT D deficiency
227
Treatment for osteomalacia?
Colecalciferol (vitamin D₃)
228
Budd-Chiari triad?
Abdo Pain, Ascites, Tender Hepatomegaly An uncommon disorder characterized by obstruction of hepatic venous outflow. The obstruction may be thrombotic or non-thrombotic anywhere along the venous course from the hepatic venules to junction of the inferior vena cava (IVC) to the right atrium.
229
Man has gastroenteritis with bloody diarrhoea. He later develops parasthesia and weakness in his legs, which progresses to his upper limbs. A diagnosis of Guillain-Barre Syndrome (GBS) is suspected and he is started on IV immunoglobulin. Which of the following is the most likely cause of his gastroenteritis?
Campylobacter jejuni Common cause of GBS (Shigella is another cause of bloody diarrhoea, but not a cause of GBS)
230
A 45-year-old man presents with abdominal pain, yellowing of the skin and eyes, dark urine, and pale stools. Which of the following is the most likely cause of his jaundice?
Gallstones - cause jaundice by obstructing the bile duct, leading to the accumulation of conjugated bilirubin. This leads to pale stools and dark urine.
231
Investigation of hiatus hernia?
Barium meal/swallow
232
3 main causes of bowel obstruction?
ADHESIONS (scar tissue adhering bowel) HERNIA CANCER
233
Management of bowel obstruction?
DRIP - IV fluids to rehydrate after their vomiting SUCK - NG tube to drain stomach contents (reduces risk of vomiting + aspiration)
234
Chronic mesenteric ischaemia
‘Intestinal angina’ **Atherosclerosis of mesenteric blood vessels** 1) Central colicky abdominal - 30 mins after eating, lasting 1-2 hours 2) Weight loss - due to food avoidance 3) Abdominal bruit (blowing sound caused by turbulent blood flow through blood vessels)
235
Diagnostic investigation for chronic mesenteric ischaemia?
CT angiogram
236
Revascularisation procedures for chronic mesenteric ischaemia?
- 1st line - endovascular => percutaneous mesenteric artery stenting 2nd line: - Endarterectomy (’cleaning out’ blood vessel) - Re-implantation - Bypass surgery
237
Cause of acute mesenteric ischaemia?
Over 50% mortality Typically caused by rapid blockage of flow through the superior mesenteric artery By a THROMBUS, or an embolus (from another site)
238
Diagnostic test for acute mesenteric ischaemia?
Contrast CT abdo => bowel and blood supply - Metabolic acidosis in ABG (raised lactate)
239
What is orthopnoea?
Breathlessness when lying flat, relieved by sitting or standing (ask how many pillows they use) ^^symptom of chronic heart failure
240
What is Paroxysmal nocturnal dyspnoea?
Describes the experience that patients have of suddenly waking at night with a severe attack of shortness of breath, cough and wheeze. ^^symptom of chronic heart failure
241
Types of kidney stones?
- Calcium (80%) - calcium oxalate & calcium phosphate - Uric acid - Struvite - Cystine
242
Which type of kidney stone is not visible on X-ray?
Uric acid stones
243
Which type of kidney stone is associated with bacterial infection?
Struvite
244
Which material usually makes up a staghorn calculus?
Struvite - form in the shape of renal pelvis during upper UTI
245
Symptoms of kidney/renal stones?
Asymptomatic Renal colic (loin to groin pain) Haematuria Reduced urine output Nause/vomiting
246
Investigations for renal stones?
- Urine dipstick (haematuria) - Blood test for kidney function + calcium - Non-contrast CT KUB (kidney, ureter, bladder) - Ultrasound KUB (in pregnant women + children)
247
Non-surgical management of renal stones?
- NSAIDs - Anti-emetics - Watchful waiting (0-10mm) - Tamsulosin (alpha blocker)
248
Surgical management of renal stones?
Surgical interventions required in larger stones (>10mm) - Extracorporeal shockwave lithotripsy (under X-ray guidance) - Uretroscopy + laser lithotripsy - Percutaneous nephrolithotomy (nephroscope inserted in small incision in back) - OPEN SURGERY
249
Treatments for prostate cancer?
- Watchful waiting - External beam radiotherapy - Brachytherapy (radioactive metal seeds = targetted radiotherapy) - Hormone therapy - androgen receptor blockers, GnRH agonists (goserelin), GnRH antagonists (degarelix) - RADICAL prostatectomy
250
Staging system for testicular cancer?
Royal Marsden staging system - Stage 1 – isolated to the testicle - Stage 2 – spread to the retroperitoneal lymph nodes - Stage 3 – spread to the lymph nodes above the diaphragm - Stage 4 – metastasised to other organs
251
NICE referral criteria for painless haematuria (2 week wait referral)?
Two-week wait referral for: - Aged over 45 with unexplained visible painless haematuria, either without a UTI or persisting after treatment for a UTI - Aged over 60 with microscopic haematuria (not visible but positive on a urine dipstick) PLUS: - Dysuria (pain urinating) or; - Raised white blood cells on FBC
252
Diagnostic investigation for bladder cancer?
Flexible cystoscopy (camera through the urethra into the bladder) - rigid or flexible
253
Management of bladder cancer?
- TURBT (transurethral resection of bladder tumour) - Intravesical chemotherapy - Intravesical BCG - thought to stimulate the immune system - Radical cystectomy = remove entire bladder
254
Presentation of renal cell carcinoma?
The classic triad of presentation is haematuria, flank pain and a palpable mass.
255
Risk factors for renal cell carcinoma?
- Von Hippel-Lindau Disease - Smoking - Obesity - Hypertension - End-stage renal failure - Tuberous sclerosis
256
Paraneoplastic features of RCC?
- Polycythaemia – due to excess EPO - Hypercalcaemia – due to secretion of a hormone that mimics the action of parathyroid hormone - Hypertension – due to various factors, including increased renin secretion, polycythaemia and physical compression - Stauffer’s syndrome – abnormal liver function tests (raised ALT, AST, ALP and bilirubin) without liver metastasis
257
Diagnostic investigations in pulmonary embolism?
**Wells score** is used when considering pulmonary embolism. The outcome decides the next step: - Unlikely: perform a d-dimer, and if positive, perform a CTPA - Likely: CT pulmonary angiogram (CTPA) or alternative imaging (see below) - CTPA: chest CT scan with an intravenous contrast that highlights the pulmonary arteries to demonstrate any blood clots - V/Q SPECT scan - Planar VQ scan
258
Mode of action of NSAIDs on the GFR? (why are NSAIDs contraindicated in CKD?)
Inhibits prostaglandins = causes vasoconstriction of afferent arteriole = reduced GFR (hence contraindicated in CKD where GFR is already dangerously low)
259
What part of the kidney does renal cell carcinoma arise from?
Proximal renal tubular epithelium
260
Why is renal cell carcinoma associated with polycythaemia?
RCC = excess EPO from kidney = excess RBCs
261
Where does FUROSEMIDE act in the kidney?
Thick ascending limb of Loop of Henle
262
Why is sarcoidosis associated with renal stones?
Sarcoidoisis = hypercalcaemia = calcium oxalate renal stones
263
Blood test findings in sarcoidosis?
- RAISED ACE - RAISED CALCIUM (hypercalcaemia)
264
Three anatomical locations where ureter narrows, which can cause renal stone obstruction?
- Pelvi-ureteric junction (renal pelvis meets ureter) - Pelvic brim (overlap with common iliac artery) - Vesico-ureteric junction (ureter meets bladder)
265
What type of renal stone is most commonly associated with urease-producing bacteria?
Struvite
266
Diagnostic investigatiojn for nephrolithiasis?
Non-contrast CT kidney, ureter, bladder (NCCT-KUB)
267
Lifestyle measures for prevention of renal stone formation in the future?
Increase water intake Reduce sodium diet Exercise Reduce oxalate-rich foods Vit C reduction
268
Side effects of tamsulosin?
Alpha-1 blocker in BPH => retrograde ejaculation => postural hypotension
269
FINASTERIDE - mode of action?
Inhibitor of 5-alpha-reductase. This enzyme changes testosterone to di-hydrotestosterone, which causes the prostate to grow. Thus, less DHT = decreases prostate size
270
Zones of prostate implicated in BPH vs prostate cancer?
BPH = transitional zone Prostate cancer = peripheral zone
271
Most common cause of nephrotic syndrome in children + in adults?
Children = minimal change disease Adults = focal segmental glomerulosclerosis
272
Diagnostic investigation for nephrotic syndrome?
Renal biopsy
273
How can you distinguish between Post-strep glomerulonephritis + IgA nephropathy by their time frames?
Post-strep = 1-2 weeks IgA (Berger's) = 1-2 days
274
Diagnostic test and value for CF?
Sodium chloride sweat test NaCl >60mmol/L
275
Duration for TB treatment?
6 MONTHS: - 2 months of RIPE - Further 4 months of RI
276
Causes of Cushing's syndrome?
CAPE - Cushing’s disease - pituitary adenoma releasing excess ACTH - Adrenal adenoma - adrenal tumour releasing excess cortisol - Paraneoplastic syndrome - ectopic ACTH (released from tumour somewhere other than the pituitary gland) ⇒ most common is small cell lung cancer - Exogenous steroids - patients taking long-term corticosteroids
277
Metabolic effects of Cushing's?
Hypertension Cardiac hypertrophy Type 2 diabetes Dyslipidaemia (raised cholesterol and triglycerides) Osteoporosis
278
What is Nelson's syndrome?
Where patients undergo a bilateral adrenalectomy (in cushing's), an ACTH-producing pituitary tumour may develop due to the lack of cortisol and negative feedback. Causing: - Skin pigmentation (high ACTH) - Bitemporal hemianopia - Lack of other pit. hormones
279
Short synacthen test?
Synthetic ACTH Give synachten + measure baseline cortisol levels Measure at 30 + 60 mins Normally, cortisol will double => no increase = primary adrenal insufficiency (Addison's)
280
How could you measure ACTH levels to distinguish primary + secondary adrenal insufficiency?
PRIMARY: ADDISONS = autoimmune destruction of adrenal glands = high ACTH (due to neg feedback from low cortisol prod.) SECONDARY: issue with production from pit. gland = low ACTH (pit gland is not producing ACTH)
281
Renin levels in primary adrenal insufficiency?
PRIMARY: ADDISONS = autoimmune destruction of adrenal glands = low aldosterone = less Na+/water in = hypotension ==> INCREASE IN RENIN (RAAS system trying to increase BP)
282
Antibodies in Hashimoto vs Graves?
HYPO: anti-TPO + anti-Tg HYPER: anti-TSH receptor
283
Secondary hypothyroidism?
Due to pituitary issue or hypothalamus, not THYROID ITESELF => NO TSH FROM PIT GLAND - pituitary adenomas - Sheehan’s syndrome (postpartum haemorrhage causes pituitary gland necrosis)
284
Presentation of polymyositis + dermatomyositis?
- Gradual-onset, symmetrical, proximal muscle weakness, causing difficulties standing from a chair, climbing stairs or lifting overhead. - Muscle pain (myalgia), but not always. - Dermatomyositis ALSO HAS SKIN FEATURES: - Gottron lesions (hands+knees) - Heliotrope rash - Periorbital oedema - Photosensitive erythematous rash on the back, shoulders and neck
285
Diagnosis of polymyositis + dermatomyositis?
- Elevated creatine kinase - Autoantibodies (ANA + anti-Jo-1 in polymyositis) - Electromyography - MRI - Muscle biopsy
286
Presentation of scleroderma (systemic sclerosis)?
LIMITED CUTANEOUS SYSTEMIC SCLEROSIS = CREST - Calcinosis - Raynaud’s phenomenon - Eosophageal dysmotility - Sclerodactyly - Telangiectasia ----- DIFFUSE CUTANEOUS SYSTEMIC SCLEROSIS = CREST, plus: - Cardiovascular problems (e.g., hypertension and coronary artery disease) - Lung problems (pulmonary hypertension and pulmonary fibrosis) -Kidney problems (glomerulonephritis and scleroderma renal crisis)
287
Autoantibodies for systemic sclerosis / scleroderma?
- ANA - Anti-centromere (limited cut SS) - Anti-Scl-70 (diffuse cut SS)
288
Diagnosis of systemic sclerosis / scleroderma?
- antibodies (know each) - abnormal nailfold capillaroscopy (to indicate secondary reynauds)
289
Management of systemic sclerosis / scleroderma?
[no standardised treatment) - Immunosuppressants + steroids (in diffuse sc ss) - Nifedipine - Raynaud’s phenomenon - PPI - acid reflux - Prokinetic medications - GI symptoms - Analgesia (joint pain) - Antibiotics for skin infections - Antihypertensives (ACEi) to treat hypertension and scleroderma renal crisis
290
Pathophysiology of Sjogren’s syndrome
Autoimmune destruction of the exocrine glands, notably the lacrimal and salivary glands => causing symptoms of dry mouth, eyes and vagina. [Dry eyes and dry mouth can be called sicca symptoms] More common in women and typically presents in middle age.
291
Diagnosis of Sjogren’s syndrome?
- Anti-Ro - Anti-La - Schirmer test (<10mm travelled along filter paper)
292
Complications of Sjorgens syndrome
- Eye problems - Keratoconjunctivitis sicca and corneal ulcers - Oral problems - dental cavities & candida infections. - Vaginal problems - Candida infection and sexual dysfunction
293
Presentation of reactive arthritis?
CAN’T SEE, CAN’T PEE, OR CLIMB A TREE - Bilateral conjunctivitis - Anterior uveitis - Circinate balanitis
294
Schober's test?
ANKYLOSING SPONDYLITIS To assess mobility, particularly lumbar spine - Patient stands straight - Find L5 - Mark point 10cm above, and 5cm below L5 - Ask patient to bend forward - Measure distance between two points (if its less than 20cm, this indicates restriction of lumbar movement = supports diagnosis)
295
X-ray findings in ankylosing spondylitis?
- Bamboo spine (in late stages) - Squaring of the vertebral bodies - Subchondral sclerosis and erosions - Ossification of the ligaments, discs and joints (structures start turning into bone) - Fusion of the facet, sacroiliac and costovertebral joints
296
Arthritis mutilans
Most severe form of psoriatic arthritis - Osteolysis of bones = shortening of fingers = skin folds = TELESCOPING 'PENCIL-IN-CUP ON XRAY'
297
Most common cause of osteomyelitis in: - normal - IVDU - post-op
Normal - S.aureus IVDU - pseudomonas aeruginosa Post-op joint replacement - S.epidermidis Sickle cell anaemia - Salmonella
298
Management of osteomyelitis?
- 6 weeks flucloxacillin if acute, 3 months if chronic - Surgical debridement of bone
299
Antibodies in anti-phospholipid syndrome?
- Lupus anticoagulant - Anticardiolipin antibody → two or more occasions at least 12 weeks apart can confirm the diagnosis of APS These antibodies bind to the phospholipids on the surface of cells, causing inflammation and increasing the risk of thrombosis.
300
Main features of anti-phospholipid syndrome?
CLOT C - clots (VTE) L - livedo reticularis (mottled lower limbs) O - obstetric loss T - thrombocytopenia
301
Autoantibodies in SLE?
ANA Anti-dsDNA
302
Man started on allopurinol (xanthine oxidase inhibitor) weeks after initial gout attack. What do we need to also give acutely?
NSAIDs Allopurinol can acutely raise the level of urate (and precipitate or worsen a flare of gout) before lowering the levels of gout. Therefore covering with an NSAID is important for reducing the risk of another flair while allopurinol therapy is initiated
303
Live vaccines?
MMR BOY (Measles, Mumps, Rubella; BCG; Oral Polio; Yellow Fever)
304
Which vessel is ischaemic stroke? - Jumbled words, RHS visual issues, RHS facial droop and hemiplegia
Left middle cerebral artery (look at stick man diagram on Notion stroke page)
305
A 27 year old woman presents to hospital with a 1 hour history of a severe, sudden onset headache. She informs you that it felt like someone had hit the back of her head with a baseball bat. She says it is the worse headache she has ever had. She is also complaining of photophobia but has no infective symptoms. She has no significant past medical history. CT head is unrevealing. Which of the following is the next best investigation to confirm the diagnosis?
Lumbar puncture 12 hours after symptom onset - CSF shows xanthochromia - yellow colour from bilirubin - CSF shows raised RBC count
306
Causes of infective endocarditis?
General pop + poor dental hygiene - S.viridans IVDU - S.aureus Prosthetic valves - S.epidermidis
307
Signs of HF on chest xray?
ABCDE Alveolar oedema Kerley B lines Cardiomegaly Dilated upper lobe vesssels Effusion (pleural)
308
ECG changes in STEMI vs NSTEMI?
STEMI: 1) ST-segment elevation 2) New left bundle branch block NSTEMI 1) ST segment depression 2) T wave inversion
309
When is troponin raised?
Used to diagnose NSTEMI (not required in STEMI, as this is based on ECG + clinical findings) Non-specific - also raised in: - Chronic kidney disease - Sepsis - Myocarditis - Aortic dissection - Pulmonary embolism
310
Which joints are spared at onset of RA?
DIP distal interphalangeal joints
311
Which joints are spared at onset of RA?
DIP distal interphalangeal joints
312
COPD severity scale (FEV1)
Graded using the ***forced expiratory volume*** ***in 1 second*** (***FEV1***): - Stage 1 (mild): FEV1 more than 80% of predicted - Stage 2 (moderate): FEV1 50-79% of predicted - Stage 3 (severe): FEV1 30-49% of predicted - Stage 4 (very severe): FEV1 less than 30% of predicted
313
Name 3 risk factors for CKD development.
T2DM Hypertension Glomerulonephritis NSAID use PKD - polycystic kidney disease
314
Suggest 4 complications of CKD.
Anaemia Osteoporosis CVD Encephalopathy/neuropathy
315
Name 4 investigations you could perform in a patient with CKD.
FBC U&Es Renal ultrasound scan Urine dip eGFR A:Cr ratio (albumin:creatinine ratio)
316
Courvoisier sign?
Enlarged gallbladder + painless jaundice (sign of pancreatic cancer) Courvoisier's law states that the presence of a non-tender ENLARGED/PALPABLE gallbladder means that jaundice is unlikely to be due to gallstones = therefore it is a red flag for pancreatic cancer
317
Reynold's pentad?
5 factors: Charcot's triad + hypotension/shock + confusion (Charcot's triad is RUQ pain, fever + jaundice)
318
Drug treatments for idiopathic pulmonary fibrosis?
Anti-fibrotics (nintedanib or pirfenidone).
319
Common associations of sarcoidosis?
- LUNGS: pulmonary fibrosis, mediastinal lymphadenopathy - SKIN: erythema nodosum - EYES: uveitis, conjunctivitis, optic neuritis KIDNEY: renal stones (due to hypercalcaemia) CNS: encephalopathy BONES: arthralgia, arthritis
320
Dull vs stony dull percussion?
Stony dull percussion - pleural effusion. Dull percussion - pneumonia
321
Investigations in suspected pulmonary fibrosis?
- DIAGNOSTIC => HRCT: high-resolution CT thorax (show honeycombing) - Spirometry (normal or restrictive >70% FEV1:FVC ratio)
322
Give 2 common organisms that can cause an infective exacerbation of COPD
most common organism = haemophilus influenzae. Others = strep pneumoniae, Moraxella catarrhalis
323
Which spirometry results indicate an obstructive respiratory disease?
FEV1 <0.8 predicted (severity scale - GOLD) FEV1/FVC <0.7
324
Chest xray findings in COPD?
Hyperinflation - enlarged lungs. Air pockets (bullae) Flattened diaphragm
325
Chest xray findings in TB?
Bilateral hilar lymphadenopathy Ghon focus (primary lesion) Effusions
326
Risk factors for TB?
Immunosuppression (HIV) Ethnicity IVDU Homeless/overcrowded housing Close contact with infected person
327
Acute asthma attack management?
OSHITME O2, SABA, Hydrocortisone, Ipratropium, Theophylline, Mg sulfate, Escalate
328
Give 4 triggers for allergic asthma
Cold temp, exercise, dust, NSAIDs, beta-blockers, infection, stress, allergens
329
Name 4 signs of poorly controlled asthma in the history
Nocturnal cough, multiple exacerbations, wheeze, recessions, hyperinflated chest
330
List three complications that can arise as a result of chronic liver disease
Ascites Portal hypertension = GI bleeding /varices /variceal bleed Hepatic Encephalopathy Spontaneous bacterial peritonitis Hepatocellular carcinoma Malnutrition Splenomegaly, thrombocytopenia, Hepato Renal Syndrome, Hepatic Failure, Infection, Pulmonary Complication, Porto pulmonary hypertension, Hepato-pulmonary syndrome (HPS), Hepatic hydrothorax, coagulation defects, Osteoporosis
331
Name 1 blood marker that may be used to monitor progression of pancreatic cancer?
Ca 19-9 (raised in cholangiocarcinoma, pancreatic cancer + gastric cancer)
332
Diagnostic investigations for ACHALASIA?
- **Barium swallow** ⇒ bird’s beak sign - **Manometry** - measures muscle pressure - **OGD** *(oesophago-gastro-duodenoscopy)* to exclude oesophageal cancer
333
Treatment for ACHALASIA?
Surgery is curative - Balloon dilation (using endoscope) - Laparoscopic (keyhole) cardiomyotomy / Heller’s procedure - cut the muscle fibres (lower oesophageal sphincter) ⇒ causes iatrogenic GORD - so they can also perform Nissen’s fundoplication at the same time.
334
Extraintestinal signs of IBD?
APIESAC - Aphthous ulcers (mouth) - **Pyoderma gangrenosum** (rapidly enlarging, painful skin ulcers) - **I**ritis (episcleritis, scleritis and anterior uveitis) - **Erythema nodosum** (red nodules on shins) - **Sclerosing cholangitis (PSC -** particularly with ulcerative colitis) - **Arthritis (enteropathic) - Clubbing of fingers - EYE (episcleritis, anterior uveitis) - Enteropathic arthritis (spondylarthropathy) - Erythema nodosum - Pyoderma gangrenous
335
Signs of appendicitis?
Rovsing’s sign (palpation of the left iliac fossa causes pain in the RIF) Rebound tenderness in the RIF (increased pain when suddenly releasing the pressure of deep palpation) Central abdominal pain = moves to right iliac fossa in first 24 hours Guarding on abdominal palpation (voluntary contraction of the abdominal wall musculature to avoid pain) Tenderness at McBurney’s point
336
Clinical signs of peritonitis?
- ***Rebound tenderness*** in the RIF (increased pain when **suddenly releasing** the pressure of deep palpation) - ***Percussion tenderness*** (pain and tenderness when percussing the abdomen) ***Rebound tenderness*** and ***percussion tenderness*** suggest ***peritonitis***, potentially indicating a ***ruptured appendix***.
337
Causes of peritonitis?
- Appendicitis = ruptured appendix - Stomach or duodenal ulcer perforation - Cirrhosis = **spont. bacterial peritonitis** - Pancreatitis or cholecystitis *(tend to be localised)* - Perforated diverticulum - Peritoneal dialysis - external contamination - In females - pelvic inflammatory disease
338
Risk factors for colorectal cancer?
- Family history of bowel cancer - IBD - Diet (high in red and processed meat and low in fibre) - Obesity and sedentary lifestyle - Smoking - Alcohol Autosomal dominant: - Familial adenomatous polyposis (FAP) - HNPCC / hereditary nonpolyposis colorectal cancer (Lynch syndrome)
339
Antibiotics that inhibit protein synthesis? (target ribosome)
Macrolides (clarithromycin + erythromycin) Chloramphenicol => inhibit 50S subunit Tetracyclines (doxycycline) Aminoglycosides (gentamicin) => inhibit 30S subunit
340
Antibiotics that inhibit cell wall synthesis?
Penicillins Cephalosporins Carbapenems Glycopeptides (vancomycin + teicoplanin)
341
Antibiotics that inhibit folic acid metabolism?
Sulfamethoxazole Trimethoprim
342
Antibiotics that inhibit nucleic acid metabolism?
Metronidazole Ciprofloxacin Trimethoprim
343
Extraarticular manifestations in in ankylosing spondylitis?
- **A** – **A**nterior uveitis - **A** – **A**ortic regurgitation - **A** – **A**trioventricular block (heart block) - **A** – **A**pical lung fibrosis (fibrosis of the ***upper lobes*** of the lungs) - **A** – **A**naemia of chronic disease
344
Chromosomes that translocate - Philadelphia chromosome?
t(9;22)
345
Peak flow values for each asthma severity classification?
MODERATE:  50-75% best or predicted ACUTE SEVERE: 33-50% best or predicted LIFE-THREATENING: < 33% best or predicted
346
Investigation of upper GI bleed?
Oesophago-gastro-duodenoscopy (OGD) (endoscopy) is required to diagnose and treat the source of the bleeding
347
definition of a granuloma?
an aggregation of epitheloid histocytes
348
Management of nephrotic syndrome?
- High dose steroids (prednisolone) Given for 4 weeks, then weaned over further 8 weeks - Low salt diet - Diuretics - for oedema
349
Complications of nephrotic syndrome?
- Hypovolaemia - causing low BP - Thrombosis - due to loss of albumin which normally prevents clotting, also liver responds to low albumin by producing pro-thrombotic proteins - Infection - Acute or chronic renal failure - Relapse
350
Management of GORD
- ***Reviewing medications*** (stop NSAIDs) - ***Proton pump inhibitors*** (omeprazole and lansoprazole) - ***Antacids*** (Gaviscon + Rennie) – short term only - ***Histamine H2-receptor antagonists*** (famotidine) - ***Surgery - laproscopic fundoplication -*** tying the fundus of the stomach around the lower oesophagus to narrow the lower oesophageal sphincter.
351
Components of non-invasive liver screen?
liver function tests - including gamma GT and total protein ethanol coagulation tests, including INR and APTT hepatitis serology - for A, B, and C viral screen, for CMV, EBV etc ferritin and total iron binding capacity immunoglobulins and protein electrophoresis autoantibody screen alpha-feto protein alpha 1 antitrypsin serum copper, ceruloplasmin, 24 hour copper Anti-mitochondrial antibodies Anti-nuclear antibodies
352
three cardinal signs of heart failure
shortness of breath, fatigue and ankle oedema
353
Biopsy histology findings in coeliac disease?
in small intestine - mainly jejunum - Raised intra-epithelial lymphocytes - Villous atrophy - Crypt hyperplasia
354
adolescent with a sore throat, who develops an itchy rash after taking amoxicillin?
Infectious mononucleosis (glandular fever) causes an intensely itchy maculopapular rash in response to amoxicillin or cefalosporins.(given these for wrongly presumed tonsilittis)
355
Risk factors for osteoporosis?
SHATTERED FAMILY Steroid use Hyperthyroidism/hyperPTH Alcohol + smoking Thin (BMI<22) Testosterone (LOW) Early menopause Renal/liver failure Erosive bone disease (RA) Diabetes FAMILY HISTORY
356
First line med for osteoporosis?
Bisphosphonates (alendronate, risedronate, zoledronic acid)
357
Instructions for taking bisphosphonates in osteoporosis? + reason for this (i.e. side effects)
first thing in the morning - empty stomach with glass of water - sit upright for 30 mins - reflux - oesophageal erosions other SEs: - atypical fractures - jaw osteonecrosis
358
Components of Glasgow-Blatchford score?
A score above 0 indicates a high risk for an upper GI bleed. - Haemoglobin (**falls** in upper GI bleeding) - Urea (**rises** in upper GI bleeding) - Systolic blood pressure - Heart rate - ***Melaena*** (black, tarry stools) - ***Syncope*** (loss of consciousness) - Liver disease - Heart failure
359
Which benzodiazepine may be used to manage the effects of alcohol withdrawal?
Chlordiazepoxide
360
Extradural vs subdural haematoma SHAPE?
Subdural - banana (S saucy) Extradural - lemon (extra zingy)
361
Typical x-ray changes seen in patients with myeloma
Well-defined lytic lesions (described as looking “punched-out”) Diffuse osteopenia Abnormal fractures Raindrop skull/pepper pot skull - refers to multiple lytic lesions seen in the skull
362
Features of decompensated liver disease?
A – Ascites H – Hepatic encephalopathy O – Oesophageal varices bleeding Y – Yellow (jaundice)
363
Monitoring for complications in liver cirrhosis?
- MELD score every 6 months - Ultrasound + alpha-fetoprotein every 6 months for hepatocellular carcinoma - Endoscopy every 3 years for oesophageal varices
364
Complications of liver cirrhosis?
- Malnutrition + muscle wasting - Portal hypertension, oesophageal varices (+ bleeding varices) - Ascites + spontaneous bacterial peritonitis - Hepatorenal syndrome - Hepatic encephalopathy - Hepatocellular carcinoma
365
Management options for ascites in liver cirrhosis?
- Low sodium diet - Aldosterone antagonists (spironolactone) - Paracentesis (ascitic tap or ascitic drain) - Prophylactic antibiotics (ciprofloxacin/norfloxacin) when there is <15 g/litre of protein in the ascitic fluid - Transjugular intrahepatic portosystemic shunt (TIPS) - in refractory ascites - Liver transplantation - in refractory ascites
366
Examination findings in liver cirrhosis?
- Cachexia (wasting of the body and muscles) - Jaundice - raised bilirubin - Hepatomegaly (then small nodular liver as it becomes more cirrhotic) - Splenomegaly due to portal hypertension - Spider naevi (telangiectasia with a central arteriole and small vessels radiating away) - Palmar erythema caused by elevated oestrogen levels - Gynaecomastia and testicular atrophy in males due to endocrine dysfunction - Bruising due to abnormal clotting - Excoriations (scratches on the skin due to itching) - Ascites  - Caput medusae (distended paraumbilical veins due to portal hypertension) - Leukonychia (white fingernails) associated with hypoalbuminaemia - Asterixis (“flapping tremor”) in decompensated liver disease
367
What do we co-prescribe with RIPE drugs for TB? (for side effects)
Pyridoxine - Isoniazid - causes peripheral neuropathy, so co-prescribe pyridoxine (vitamin B6) to prevent this.
368
Risk factors for psuedogout? (chondrocalcinosis)
-Older age - Haemochromatosis (iron deposits in joints) - Hyperparathyroidism (=high calcium) - Hypophosphatasia - Hypomagnesaemia - Hypothyroidism - Acromegaly
369
Causes of raised JVP?
- Right-sided heart failure: commonly caused by left-sided heart failure (e.g. secondary to fluid overload). - Pulmonary hypertension is another cause of right-sided heart failure, often due to chronic obstructive pulmonary disease or interstitial lung disease. - Tricuspid regurgitation: causes include infective endocarditis and rheumatic heart disease. - Constrictive pericarditis: often idiopathic, but rheumatoid arthritis and tuberculosis are also possible underlying causes.
370
What does a dorsal column medial lemniscus lesion result in? 1 - Contralateral loss of proprioception, vibration and fine touch 2 - Ipsilateral loss of proprioception, vibration and fine touch 3 - Ipsilateral loss in coordination
Ipsilateral loss of proprioception, vibration and fine touch
371
What does an spinothalamic/anterolateral system lesion result in? - Contralateral loss of crude touch, pressure, pain and temperature sensation - Ipsilateral loss of crude touch, pressure, pain and temperature sensation - Ipsilateral loss of coordination
Contralateral loss of crude touch, pressure, pain and temperature sensation
372
Where does the spinal cord terminate?
L1/L2
373
Which muscle isn’t innervated by the oculomotor nerve? Superior rectus Inferior oblique Superior oblique Levator palpebrae
SO4 sueprior oblique muscle supplied by CN4 trochlear nerve => SO controls depresssion + abduction (when disrupted, patient cannot look down when eye is adducted)
374
Sepsis 6?
Give 3 Take 3 => BUFALO Blood Cultures Urine output Fluids Antibiotics Lactate Oxygen
375
Tumour lysis syndrome?
Tumour lysis syndrome is a potentially lethal condition caused by the rapid death of tumour cells often following chemotherapy or rapid progression of haematological malignancies, resulting in the massive release of intracellular contents. It is an oncological emergency. Presentation => acute-onset dysuria/oliguria, abdominal pain, or weakness. Key investigations => U&E (showing raised potassium and phosphate), calcium (typically low), uric acid (raised), and ECG to detect metabolic abnormalities and life-threatening arrhythmias. Initial management => correction of electrolyte abnormalities and IV fluids.
376
Acute haemolytic transfusion reaction?
It occurs due to ABO incompatibility from a blood transfusion, resulting in IgM mediated intravascular haemolysis. Patients present with features of shock, abdominal and chest pain and feeling generally unwell within minutes of the transfusion starting. The most important management step is to stop the transfusion and then begin fluid resuscitation with intravenous saline. It is also important to send a sample of the patient's blood for direct Coombs test (which will confirm antibodies have bound to the surface of the transfused red blood cells) as well as repeat blood typing and cross-matching. The laboratory should be alerted and a Datix completed
377
Common complication after TURP?
Clot retention is a common complication following TURP, hence most patients are advised to refrain from walking and lifting heavy weights for at least one week post-surgery. In the event of clot retention, an emergency CYTOSCOPY + evacuation of CLOTS and diathermy to the bleeding point is the definitive management.
378
Raised LDH and bilirubin after blood transfusion?
- ACUTE - A delayed haemolytic transfusion reaction can occur after blood transfusion, causing haemolysis with raised bilirubin levels and LDH values, usually within a week of the transfusion.
379
Miller-Fisher syndrome?
TRIAD - ataxia, areflexia and opthalmoplegia. Losing his balance and the positive Romberg’s indicated ataxia. He is also areflexic. Opthalmoplegia is present as he can’t abduct his right eye. Miller-Fisher syndrome can present with the prodrome of gastroenteritis, like Guillain-Barre, which can make things a confusing. Remember that Guillain-Barre starts distally (polyneuropathy) and makes it way up. Miller-Fisher starts proximally i.e. with the eyes.
380
What is torsades de pointes?
**Torsades de Pointes (TdP) is an arrhythmia associated with a prolonged QT interval and is life-threatening due to its potential to degenerate into ventricular fibrillation.** **Torsades de Pointes is caused by other factors such as:** - Long QT syndrome - QT-prolonging medications - Electrolyte imbalances - Bradycardia - Structural heart disease **ECG** – characterised by a **twisting/oscillating pattern** of the **QRS -** *this results from the changing axis of the QRS, which rotates around the baseline* (DANGEROUS!! - can lead to cardiac arrest!)
381
Treatment for torsades de pointes?
- Correcting underlying cause (e.g., electrolyte disturbances or medications) - Magnesium infusion (even if they have normal serum magnesium) - Defibrillation if ventricular tachycardia occurs
382
Rate control in atrial fibrillation?
**RATE CONTROL:** - 1st line - beta blocker or calcium channel blocker (not both!!) - 2nd line - add digoxin or amiodarone
383
Rhythm control in atrial fibrillation?
**RHYTHM CONTROL:** - Flecainide *(contraindicated in LV dysfunction or hypertrophy)* - Amiodarone *(can cause thyrotoxicosis)* - Electrical cardioversion - Catheter ablation
384
Complications of a myocardial infarction
“DREAD” mnemonic: D – Death R – Rupture of the heart septum or papillary muscles E – “oEdema” (heart failure) A – Arrhythmia and Aneurysm D – Dressler’s Syndrome
385
Dressler's syndrome?
aka post-myocardial infarction syndrome Usually occurs 2 – 3 weeks after an acute MI Rare form of pericarditis Caused by a localised immune response that results in pericarditis. Presents with pleuritic chest pain, low-grade fever and a pericardial rub on auscultation. It can cause a pericardial effusion and rarely a pericardial tamponade. Diagnosis can be made with ECG (global ST elevation and T wave inversion), echocardiogram (pericardial effusion) and raised inflammatory markers (CRP and ESR). Management is with NSAIDs (e.g., aspirin or ibuprofen) and, in more severe cases, steroids (e.g., prednisolone). Pericardiocentesis may be required to remove fluid from around the heart, if there is a significant pericardial effusion.
386
What does 'forehead sparing' mean?
Forehead sparing is a symptom of an upper motor neuron (UMN) lesion (such as STROKE or in bELLS PALSY), which is a facial palsy that affects the lower part of the face while sparing the forehead muscles The forehead muscles are spared because the upper half of the face is innervated bilaterally, meaning it receives supply from both the same side and opposite side of the brain. This means that if paralysis is caused by an UMN lesion, the forehead is spared A patient with a UMN lesion can wrinkle their forehead, while a patient with a lower motor neuron (LMN) lesion cannot.
387
Medical management of stable angina?
- Symptom relief - GTN spray (2x max) - Anti-anginal meds - betablocker/atenolol OR CCB/verapamil - Secondary prevention of coronary artery disease - aspirin 75mg OD and statin 80g ON
388
Anti-emetics
389
Difference between 'cross match' and 'group & save'?
*group and save - reserve blood* *cross match - actually get blood*
390
Different causes of upper GI bleeding?
- Peptic ulcers - Stomach/gastric cancer - Mallory-Weiss tears - Oesophageal varices
391
Presentation of an upper GI bleed?
- Haematemesis - Coffee ground vomit (digested blood) - Melaena
392
Blood test findings in upper GI bleed?
High urea (RBC breakdown) Low Hb
393
Investigation for upper GI bleed?
Oesophago-gastro-duodenoscopy (OGD) (endoscopy) is required to diagnose and treat the source of the bleeding
394
Management of upper GI bleed?
ABATED A - A to E assessment B - bloods (Hb, urea, coags, LFTs, crossmatch 2 units) A - access (2x large bore cannula) T - transfusions as needed E - endoscopy (OGD) within 24hrs D - drugs (stop any anti-coagulants and NSAIDs) [extra steps for oesophageal varices => Terlipressin or variceal band ligation]
395
Red flags for upper GI malignancy?
ALARMS A - anaemia L - lost weight A - anorexia (appetite) R - refractory symptoms (reflux symptoms even after M - melaena S - swallowing (dysphagia)
396
What is fresh frozen plasma?
Blood, platelets and clotting factors (used in massive bleeding)
397
Risk factors for GI ulcers? (peptic or duodenal)
- H.pylori - Stress - Alcohol - Caffeine - Smoking - Spicy foods - Aspirin - Steroids *(chronic use)*
398
Likely diagnosis when ulcers are not resolving, despite treatment?
Zollinger-Ellison syndrome: gastrin-secreting neuroendocrine tumour
399
Signs of peritonitis?
- Guarding - Rigidity - Rebound tenderness - Percussion - causes pain - Shoulder tip pain
400
Main 3 causes of small bowel obstruction?
- Adhesions (scars) - Hernia - Cancer
401
Main 3 causes of large bowel obstruction?
- Cancer - Diverticulitis - Volvulus
402
Investigation for bowel obstruction?
Contrast CT abdomen
403
What is the recommended treatment of H. Pylori negative, endoscopy-confirmed peptic ulcer disease.
4-8 weeks of high dose PPI
404
Diagnosis? 22 year old man. Sudden onset chest pain and profuse vomiting after stag do. Reduced breath sounds on RHS and dullness to percussion.
Boerhaave syndrome. Full-thickness rupture of the oesophagus, often precipitated by severe vomiting. The reduced breath sounds and dullness to percussion indicate pleural effusion, which is often seen in Boerhaave syndrome due to the leakage of gastric contents into the mediastinum and pleural space. This is a medical emergency requiring prompt treatment.
405
Diagnosis: Man returned from trip to India. Fever and bloody diarrhoea. Liver abscess. RUQ abdo pain, swinging fevers and sweats.
Entamoeba histolytica Presents with bloody diarrhoea and a liver abscess, causing RUQ pain, swinging fevers and sweats. Faecal-oral transmission Associated with travel to endemic areas and men who have sex with men
406
Second line in C.diff patients who don't respond to oral vancomycin?
Oral fidaxomicin - Used when oral vancomycin unsuccessful OR - in patients who have a second episode of Clostridium difficile infection within 12 weeks of symptom resolution from their first episode (relapse).
407
Diagnosis: post-prandial abdominal pain + weight loss + abdominal bruits (with no blood in stools etc)
Chronic mesenteric ischaemia caused by atherosclerosis in the gut supply arteries.
408
Management of PBC?
- UDCA - bile acid that protects cholangiocytes from damabge - Replacement of fat-soluble vitamins - ADEK - Cholestyramine - for pruritus
409
Blood findings in PBC?
- Raised ALP - Anti-mitochondrial antibodies
410
Radiculopathy vs myelopathy?
Radiculopathy - pinched nerve root as it leaves spine Myelopathy - compressed spinal cord
411
Which stenosis leads to sciatic pain?
Lumbar spinal stenosis => lateral and foramina stenosis = radiculopathy - compression of nerve root as it leaves spine column
412
Difference in presentation of radiculopathies vs myelopathies?
radiculopathy typically manifests as sharp, radiating pain along a specific nerve pathway (like down the arm or leg) due to a compressed nerve root, whereas myelopathy presents with more generalized weakness, clumsiness, and coordination problems due to compression of the spinal cord itself essentially, radiculopathy affects individual nerves while myelopathy impacts the entire spinal cord function.
413
Triad of normal pressure hydrocephalus?
- **Urinary incontinence** - **Dementia** - **Gait abnormality** ⇒ treated with ventriculo-peritoneal shunting
414
DIAGNOSIS: 50yo woman 3 day history of: blurred vision shoulder pain horner syndrome (ptosis, facial anhydrosis, miosis)
Pancoast tumour causing Horner syndrome Lung tumour but does not typically cause cough, instead presents with shoulder pain
415
Which spinal cord tracts are affected in subacute combined degeneration of the cord?
Degeneration of the dorsal columns and corticospinal tracts (pain and temperature are unaffected as the spinothalamic tract is intact)
416
Explain RAPD in the left eye
When the light is shone in the right eye, both pupils constrict. When the light is moved to the left eye, both pupils dilate. QUICKLY SWING ACROSS TO LEFT EYE When light shone in left eye, the pupils dilate (left eye does not detect the light due to lesion in optic nerve = optic neuritis)
417
Causes of seizures? (mnemonic)
VITAMINS Vascular - stroke, HTN, eclampsia Infections - meningitis, encephalitis Toxins - alcohol overdose, antidepressants, antipsychotics AV malformation + space occupying lesions Metabolic - hypoglycaemia, hypo/hypernatraemia, hypocalcaemia Multiple sclerosis Idiopathic Neoplasms Stress
418
Treatment of pulmonary embolism in haemodynamically unstable patients?
In cases of massive PE (hypotension for over 15 minutes), patients should be treated with thrombolysis (an IV bolus of Alteplase) => to restore pulmonary perfusion
419
Venturi mask or non re-breathe mask for COPD patients?
VENTURI to reduce the risk of over-oxygenation - it is always best to use a controlled method of oxygen delivery such as a Venturi mask in COPD patients. You are giving them O2, just through a Venturi mask instead of another method, like a non-rebreathe. Patients at risk of T2RF, such as those with COPD, have adapted to be used to the lower oxygen levels that their condition leads them to have. This means their O2 saturation ranges are normal at 88-92%. If we give them too much oxygen, we can reduce their respiratory drive, which is dangerous. Venturi masks control the amount of oxygen we give the patient, to stop us doing this :)
420
Causes of seizures? mnemonic
VITAMINS V - Vascular: stroke, aneurysms, and other vascular malformations. I - Infection: meningitis and encephalitis T - Trauma: Head injuries and birth trauma A - Autoimmune (vasculitis) OR AV malformation: abnormal connections between arteries and veins M - MS or Metabolic: electrolyte imbalances (hypoglycemia, hypo/hypernatremia), and other metabolic disorders. I - Idiopathic N - Neoplasm: brain tumours S - Stress => Psychogenic
421
Signs of normal pressure hydrocephalus?
3x Ws "wet" (urinary incontinence) "wobbly" (gait disturbance) "wacky" (cognitive impairment)
422
Causes of Horner's syndrome?
- Pancoast tumour (lung apex) - Infection - meningitis/encephalitis - Space occupying lesion - Trauma - Stroke - MS - *Migraine or cluster headache* - Large goitre - Congenital
423