Drugs

Question 1

Anti-emetics

Answer 1

(1st line)

• Chlorpromazine
• Doxylamine and pyridoxine
• Prochlorperazine
• Promethazine
• Cyclizine (antihistamine)

(2nd line)

• Metoclopramide
• Domperidone
• Ondansetron (small increased risk of cleft palate)

Question 2

Thiazide like diuretics?

Answer 2

Indapamide, metolazone, chlorthalidone

Question 3

Mechanism of action of statins?

Answer 3

HMG CoA Reductase inhibitors
Lipid lowering

Question 4

Anti-platelet drugs?

Answer 4

• Aspirin - non-selective cyclooxygenase (COX) inhibitor
• Clopidogrel / prasugrel / ticegrelor
• Dipyridamole (phosphodiesterase 3 inhibitor)

Question 5

Mode of action of potassium sparing diuretic (thiazide-like diuretic)?

Answer 5

SPIRONOLACTONE

Aldosterone antagonist!
=> prevents action of aldosterone; which usually reabsorbs Na+ (increased water=BP), secrete K+ and Na+

Question 6

Osmotic diuretic?

Answer 6

Mannitol

Question 7

Loop diuretic?

Answer 7

Furosemide
(acts on ascending Loop of Henle)

Question 8

Thiazide diuretic?

Answer 8

Bendroflumethiazide

Acts on distal collecting tubule
Blocks Na-Cl cotransport = less Na+ reabsorbed = more NA+ and water lost