Random Flashcards
Normal cystometry
- Bladder capacity
400-600mls
Normal cystometry
First sensation to void
150-250mls
Normal cystometry
Rise in detrusor pressure
<15cmH20
Normal cystometry
Voiding pressure
<70cmH20
Normal cystometry
Peak urine flow rate
> 15ml/sec
Normal cystometry
Residual volume
<50mls
What cholinergic receptors in bladder
M1
M2 (80%)
M3 (20%)
M3 responsible for detrusor connotation
What type of drugs is duloxetine
Combined 5HT and noradrenaline re-uptake inhibitor
Increases stimulation of urethral sphincter
40mg BD
Side effects of duloxetine?
GI disturbance, nausea and dry mouth
Headache, decreased labido, anorgasmia
Drugs needs to be slowly stopped over 2 weeks
Contraindications of duloxetine
Prengnacy, lactation
Hepatic impairment
Monoamine oxidase therapy
Lowers seizure threshold
Can enhance warfarin
Avoid co-prescription with SSRI and anti-depressants
When duloxetine use?
Stress incontience where 1st line treatments not worked, decline or not fit for surgery
How does mirabegron work
Detrusor relaxation via cAMP pathway
B3 agonist
Pharmacology of mirabegron
Plasma bound 71%
Volume distribution 1670L
1/2 life 50 hr
Max conc 3-4hrs
Bioavalabilirt 29% 25mg, 35% 50mg, reduced if with food
Contraindications mirabegron
Severe HTN
Avoid in pregnancy and BF
Adverse effects of mirabegron
Headache
Urinary tract infection
Tachycardia, palpitations, atrial fibrillation, increased BP
Vaginal infection, vulvo-vaginal pruritis
Dyspepsia, gastritis, abnormal LFTs,
Urticaria, rash, pruritus, joint swelling, eyelid oedema, lip oedema
Leukocytoclastic vasculitis
