Random Flashcards
King’s College Criteria for paracetamol liver failure?
pH <7.3 or lactate >3.5
OR (all of below)
INR >6.5 or PT>100 seconds
Creatinine >300
Grade 3/4 HE
King’s College Criteria for non-paracetamol induced liver failure?
INR >6.5 or PT >100 seconds
OR (at least 3 of below)
Age <10 or >40
INR >3.5 or PT >50
Bilirubin >300
Cause: HCV, idiosyncratic drug reaction, halothane
Icterus to HE >7 days
Reed Sternberg cell - cell markers?
CD30, CD15
Group 1 PH?
Pulmonary arterial hypertension
Pre-capillary pulmonary hypertension
mPAP ≥20
mPAWP <15
Group 2 PH?
PH due to left heart disease
Group 3 PH?
PH due to lung disease/hypoxia.
Pre-capillary pulmonary hypertension
Group 4 PH?
PH due to chronic thromboembolic pulmonary hypertension
Pre-capillary pulmonary hypertension
Group 5 PH?
Idiopathic PH
Pre-capillary pulmonary hypertension
First line treatment for patients with Group 1 PAH with positive vasoreactivity testing?
CCBs - nifedipine
JAK2 most associated with?
PV
What is most specific for intravascular haemolysis?
Urinary haemosiderin
Is hydroxychloroquine safe in pregnancy and breastfeeding?
Yes
Is sulfasalzine safe in pregnancy?
Yes - can be continued in patients with active inflammatory disease requiring treatment during pregnancy.
It can cause oligospermia and reversible infertility in men.
Is azathioprine/6-MP safe in pregnancy?
Yes - can be continued in patients with active inflammatory disease requiring treatment during pregnancy.
When is it most dangerous to be on NSAIDs/aspirin in pregnancy?
3rd trimester - risk of premature closure of ductus arteriosus.
