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Question 1

Cancer associated with opsoclonus-myoclonus

Answer 1

Small cell lung cancer in adults

Neuroblastoma in children

Question 2

Ainsworth attachment style

Answer 2

Secure - protest but can be comforted
Insecure avoidant - ignore mother
insecure ambivalent - needy and unable to be comforted

Question 3

facet joints

Answer 3

superior and inferior articular processes join

synovial fluid containing

Question 4

Erikson Stages of Growth

Answer 4

birth to 18 months - trust vs. mistrust (basic trust)
18 months to 3 years - autonomy vs. shame (control and independence)
3 to 6 - initiative vs. guilt (taking control of environment, purpose)
6 to 12 - industry vs. inferiority (confidence, competence, social skills)
12 to 18 - identity vs. role confusion (formation of identity, devotion)
18 to 35 intimacy vs. isolation (forming a relationship, commitment)
35 to 65 - generatively vs. stagnation (building a family, having a productive career)
65 to death - ego integrity vs. despair (viewing life as meaningful and fulfilling)

Question 5

Herpes Zoster associations

Answer 5

Acute neuritis
Post-herpetic neuralgia
Herpes zoster ophthalmicus - reactivation in ophthalmic division of trigeminal nerve
Acute retinal necrosis
Ramsay-Hunt syndrome 
Aseptic meningitis 
Encephalitis
Peripheral motor neuropathy
GBS
myelitis
Stroke

Question 6

Adrenoleukodystrophy

Answer 6

Peroxisomal protein involved very long chain fatty acid oxidative degradation –> mutations lead to accumulation and adrenal failure (ABCD1) gene on X chromosome
MRI with hyper intensities of posterior white matter, spares arcuate fibers
Different types - childhood, adolescent and adult onset types
Tx: steroids + Lorenzo’s oil

Question 7

Kluver-Bucy syndrome

Answer 7

bilateral medial temporal lobes and amygdala

Hypersexuality, hyperorality, visual agnosia, hypokinesia, blunted emotional affect, hyper metamorphosis

Question 8

HSAN1

Answer 8

AD, lower extremity pain and impaired sensation and hypohidrosis
serine palmitoyltransferase mutation –> catalyzes the rate-limiting step of sphingolipid synthesis

Question 9

Charcot-Marie-Tooth 1A

Answer 9

PMP22

distal weakness and atrophy - foot drop and pes cavus

Question 10

HSAN2

Answer 10

AR
loss of sensation, insensitivity to pain
Areflexia and retinitis pigmentosa

Question 11

HSAN3

Answer 11

AR

Autonomic dysfunction, sympathetic storm, salivation, absent tearing, dilated pupils and blotchy skin

Question 12

HSAN4

Answer 12

AR

Profound loss of pain sensitivity –> injuries

Question 13

Whipple’s disease

Answer 13

Tropheryma whippleleii

GI symptoms + oculomasticatory myorhythmia (pendular nystagmus associated with contractions of muscles of mastication)

Question 14

Wilson’s disease

Answer 14

ATP7B