Neuro-oncology

Question 1

Oligodendroglioma

Answer 1

small cells with round nuclei and scant cytoplasm (peri nuclear halos) - “fried egg”
GFAP+
presence/absence of IDH mutation
presence/absence of 1p/19q co-deletion

Question 2

Central Neurocytoma

Answer 2

small cells with round nuclei and scant cytoplasm (perinulcear halos) - fried egg appearance
synaptophysin - neuron-specific enolase positivity indicative of neuronal origin

Question 3

Anti-Hu

Answer 3

13% have neg evaluation for neoplasm
Onconeuronal antibody produced against the intracellular protein HuD, expressed in neurons
Aggressive sensory-predominant neuronopathy