Ramani Lecture Flashcards
Contraindications for EKG stress test vs. Echo
Old left branch bundle or on digoxin
What meds to stop for an EKG stress test?
Beta blockers, calcium channel blockers
Positive stress test
Pain is reproduced, ST depression, or hypotension
New systolic murmur 5-7 days post MI
Papillary muscle rupture
Acute severe hypotension after MI?
Ventricular free wall rupture “step up in oxygen from RA to RV”
Persistent ST elevation with mitral regurg post-MI
Ventricular wall aneurysm
bounding pulsating JVP
Tricuspid malfunction 2/2 AV dissociation - check for third degree heart blok
5-10 weeks post MI pleuritic CP and low grade temp (D/Tr)
Dressler’s autoimmune pericarditis, NSAIDS and aspirin
Vague chest pain with viral infection and murmur
myocarditis
Chest pain with rest and worse at night in person with migraine headaches, transient ST (D/BT/Tr)
Prinzmetal’s angina, ergonovine stim test, CCB or nitrates
Third degree heart block finding
Cannon-a waves
Varying PR intervals with 3 or more distinct P waves in same lead
Multifocal atrial tachycardia, bad prognosis, sick patients pending respiratory fialure
Normal complex QRS tachy and treatment
Vtach - unstable - cardioversion, stable - lidicoaine or amiodarone
Drug of choice for WPW
procainamide - do NOT give rate control
Torsades risk factors
Low Mg, Low K, Li, TCA OD
Young person with sudden onset and offset palpations normal rhythm 150-220 bpm
SVT - carotid massage first followed by adenosine
Widened QRS, short Qt after crush or burn?
Hyperkalemia
Electrical alternans? Low alternating qrs
Tamponade
Undulating baseline irregularly irregular too much synthroid, CHF valve dizease, or SOB/dizziness
Afib - rate control
Crescendo decrescenod, louder with squat, softer with valsalva +parvus et tardus
Aortic stenosis - replace
Late systolic murmur with a click, louder with valsalva, quieter with squatting
Mitral valve prolapse
Radiate to axilla, holosystolic
Mitral reguritation
Rumbling diastolic murmur with opening snap, left atrial enlargement
Mitral stenosis
Blowing diastolic murmur with widened pulse pressure and eponym parade
Aortic regurg
Suspect PE?
Heparin first!
O2 <90%
Give O2
Pneumonia?
CXR
Murmur or CHF?
Echo
Acute pulmonary edema?
Nitrates, lasix, and morphine
CHF in young person?
Myocarditis (coxackie B)
Young and no cardiomegaly on CXR
Right heart cath for pHTN -
Pulm cap wedge pressure in CHF and pHTN
High in CHF, normal in pHTN
Reversible cardiomyopathy
Alchol, hemochromatosis
Thickened peritracheal stripe and splayed carina bifurcation
Left atrial enlargement (mitral stenosis) and cancer
Transudative pleural effusion with low glucose
RA
Transudative pleural effusions with high lymphocytes
TB
Transient pleural effesuion with blood
Malignant or PE
What makes pleural effusion complicatied?
Exudative with +gram or cx, pH<7.2, glc <60
Lights criteria
LDH<200
LDH eff/serum <0.6
Protein eff/serum <0.5
need all three to be transudative
Cancer and nephrotic syndrome dispose to PE
Hyperoagulable
PE anticoagulation
Heparin right away then warfarin bridge
When to do surgical thrombectomy
If immediately life threatening
Criteria for ARDS
- PaO2/FiO2 <200 (<300 means acute lung injury)
- Bilateral alveolar infiltrates on CXR
- PCWP <18
ARDS treatment
Mechanical ventilation w/ PEEP
when to start O2
PaO2<55 or if cor pulmonale, <59
Typical abx for COPD exacerbation
Macrolide
Best prognostic indicator for COPD
FEV1
New clubbing in COPDr
Hypertrophic ostearthropathy, get CXR for lung cancer
Normalizing PCO2 in asthma exacerbation
Impending respiratory failure, intubate
1 cm nodules in upper lobes with eggshell calcifications
Sillicosis - more predisposed to TB, INH if >10 mm
Reticulonodular markings in lower lobes with pleural plaques
Asbestosis, increased risk for bronchogenic carcinoma and mesothelemioma
Patchy lower lobe infiltrates (D/P)
Hypersensitivity pneumonitis, “farmer’s lung”
Hilar lymphadenopathy
Sarcoid
Sarcoid with hypercalcemia
Increased vit D due to macrophages in granulomas producing vit D like substance
Referral for sarcoid?
Opthalmology - uveitis conjunctivits in 25%
How to dx sarcoid
Biopsy, treat with steroids
First step in pulm nodule workup
Look for old CXR
Characteristics of benign pulm nodule
Popcorn calcification (hamartoma) Concentric calcification (old granuloma) Pt<40 with well circumscribed <3 cm 0 watch with CT q2mo
Malignant nodule characteristics
Spiculated, large (>3 cm), old smoker
Weight loss, cough, dyspnea, hemoptysis, repeatned PNA or lung collapse
Cancer
Most common non-smoker cancer
Adeno - scars of old pna
Location and mets of adeno?
Periopheral cancer, liver bone brain and adrenal
Characteristic pleural effusion of adeno?
Exudative with high hylauronidase
Scary lung cancer symptoms with low PTH AND hypercalcemia
Squamous cell - PTH-rP
Shoulder pain, ptosis, constricted pupil, facial edema
Superior sulcus syndrome, small cell carcinoma
Cancer associated with Lamber-Eaton?
Small cell
Old smoker w/ Na=125, moist mucus membranes, no JVD
SIADH from small cell - euvolemic hyponatremia
CXR with peripheral cavitation and CT with distant mets
Large Cell carcinoma
Difference between small cell and Nsmall cell
Nsmall cell chemo, small cell resection
Crohn’s deficiency by involving ileum?
Fe deficiency?
PSC associated with which IBD?
UC
Higher risk with colon cancer in crohn’s or UC?
UC
Cured by colectomy?
UC
Associated with p-ANA IBD?
UC
Pyoderma gangrenosum with UC antibiotics?
No I+D, no antibiotics
AST>ALT with high GGT
Alc Hep
ALT>AST in 1000’s
Viral hepatitis
AST and ALT in 1000’s after surgery?
Shock liver - ALT is NOT greater than AST
Elevated alk phos AND GGT
Bile duct obstruction
Elevated alk phos, normal GGT and Ca
Paget’s disease, hearing loss (bisphosphonates)
Antimitochondrial Ab
PSC - bile resins for treatment
ANA + antismooth muscle Ab
Autoimmune Hepatitis - tx w/ roids
High Fe, low ferritin, low Fe binding capacity
Hemachromatosis, golden diabetes
Low ceruloplasmin, high urinary Cu
Wilson’s
Why add ampicillin for empiric meningitis treatment for old and young?
Lysteria coverage
TB treatment
RIPE and roids
Lyme meningitids treatment
IV ceftriaxone
Best 1st step
Start treatment with steroids if you think bacterial
Most common pneumoniae in healthy young people?
Mycoplasma - cold agglutainins
HAP bugs?
Pseudomonas, Klebsiella, E.Coli, MRSA - pit/tazo or imipenem + Vanc
Old smokers w/ COPD
Hflu
Old men with HA, confusion, diarrhea, and abd pain
Legionella - dx w/t urine antigents, M,FQ, doxy
Farmers pneumonia
Q-fever, Coxiella burnetti, doxy
Just skinned a rabbit in Arkansas
Franciella tularensis, streptamycin, gentamycin
Order of tests in TB workup
PPD, CXR, sputum stain
Who is given INH for prophylaxis
Kids <4TB
+TB treatment
RIPE for 6 mo, 12 for meningitis, 9 if pregnant
Rifampin side effects
Orange/red boddy fluids, induces CYP450
INH side effects
Peripheal neuorpathy and sideroblastic anemia (prevent by giving B6(pyridoxine)), Hepatitis
Pyrazinamide
Benign hyperuricemia
Ethambutol
optic neuritis and impaired color vision
Most common endocarditis bug?
staph aureus
Subacute native valve
Viridans group strep on MV
IVDU endocarditis?
Staph on tricuspid - right sided heart murmurs worse w/ inspiration
Strep bovis bacteremia?
Colonoscopy
Most common cause of death in endocarditis
CHF
Prophylaxis for endocarditis
Prostetic valve, hx of EC, or uncorrected congenital lesion
“travels a lot for work”
Code for lots of unprotected sex
Acute retroviral syndrom 2-3 weeks after exposure symptoms? Seroconversion?
Mono symptoms, ELISA is negative, converts aroudn 6 weeks
New bilateral bell’s palsy
Can be HIV
young patient unexplainted thrombocytopenia
Can be HIV
Zidovudine side effects? Classic and important
GI, leukopenia, macrocytic anemia
Didanosine Side effects
Pancreatitis, peripheral neuropathy
Abacavir side effects
Rash, fever, n/v, muscle aches, and SOB - never use again
Nephrolithiasis and hyperbilirubinemia
Indinavir
Efavirenz side effects
Sleepy, confusded, psycho
Post-exposure prophylaxis
AZT, lamivudine, and nelfinavir x 4 weeks
HIV patient with DOE, dry cough, fever, chest pain
Think PCP, CD4<200
PCP blood elevation
LDH
Best test for PCP after CXR?
Boncoscopy w/ BAL
1st and 2nd line treatment for PCP
Trim-sulfa, then trim-dapsone
When to add steroids for PCP
PaO2 <70, high A-a gradient
When to start prophylaxis?
CD4<200, can come off after 6 mo >200
Three major causes of diarrhea in HIV+ patient
CMV, MAC, cryptosporidium
CMV dx in HIV
Colonoscopy with biopsy, treat with canciclovir
Cryptosporidium dx in HIV
Acid fast oocysts
Multiple ring enhancing lesions in HIV? One ring enhancing lesion?
Toxo multiple, CNS lymphoma if one, treat with pyramethamine sulfadiazine +folic acid then watchc for improvement, if it improves probably toxo
HIV seizure w/ deja vu aura and 500 RBC’s in CSF
HSV - immediate acyclovir
HIV with s/s of meningitis
Strep pneumo most common, but thinkCrypto, +india ink, ampho IV 2wks then fluconazole
HIV hemisensory loss, visual impairmarment, Babinksi
PMLdue to JC virus, brain biopsy diagnosis
HIV memory problems or gait disturbance
AIDS-Dementia complex, work up to find other treatable causes
Define neutropenic fever
Super high temp or sustained low temp with ANC <500
Most common cause of neutropenic fever
Meucositis 2/2 chemo causes bacteremia
Most common bugs of neutropenic fever?
Pseudomonas and MRSA
Lyme disease treatment for <8
amoxacillin
Rash at wrists and ankles, fevers, and headache
Rikettsia, everyone get doxy
Tick bite w/o rash but myalgias, fever, headaches, low plts and WBC, up ALT
Ehrlichiosis, Can dx with morulae intracell inclusion, tx w/ doxy
Immune suppressed pt with cavitary lung dz, wegith loss, fever, gram +aerobic branching bugs
Nocardia - tx w/ trim-sulfa
Numbness, Chvostek, prolonged QT
Hypocalcemia
Paralysis, ileus, ST depression, U waves
Hypokalcemia
Treatment for hyperkalemia
Ca-gluconate, insulin +glc, kayexalate, albuterol, and NaBicarb - last resort diuretics then dialysis
Best test for metabolic alkalosis
Urine chloride - high urine chloride? hyperaldo, barters, gittlemans. Cl low, vomitting, NG suction, antacids, diuretics
RTA Type I (proximal or distal, cause, presentation, treatment)
Distal
Lithium/AmphB, analgesics
Urine pH>5.4 with hypoK and stones, cannot secrete H+
Give K and oral bicarb
RTA Type II (proximal or distal), cause, presentation, treatment
Proximal
Fanconi’s syndrome, myeloma, amyloid
Hypokalemia, osteomalacia, cannot reabsorb HCO3
Bicarb won’t help (because they can’t reabsorb), replete K
RTA Type IV
Hyperrenin hypoaldo - Mostly caused by diabetes, HyperK, high urine NA even with salt, treat with fludrocortisone
what to use for urine concentration if on diuretic
FENurea
Muddy brown casts in ampho, aminocglycosides, cisplatin, or prolonged ischemia?
ATN
Protein, blood and eosinophils in urine plus fever and rush after trim-sula?
AIN. stop offending agent
Treatment for rhabdo
Deal with hyperkalemia nad bicarb to alkalinize urine and prevent precipitation
Enveloped shaped crystals in UA
Ethylene glycol (AGMA), Tx w/ dialysis or bicarb if low pH
Cr up 48-72 hrs post cardiac ccath or CT scan
Contrast nephropathy, hydrate before and give bicarb or NAC
Indications for emergent dialysis
A - acidosis E-Electrolye impalance (high K) I- Intoxication - antifreeze, Li O- Overload of volume, CHF or Pulmonary edema U-uremia -> pericarditis, AMS
Most common CKD complications
Cardiovascular dizease - LDL <100
Complications of CKD
HTN - up aldo
Anemia of chronic disease - loss of Epo
Hyper K, hyper phos, low calcium -> 2nd HPTH, renal osteodystrophy from Ca into tissues, calciphylaxis (skin necrosis)
Uremia
Peeing blood 1-2 days after runny nose, sore throat, and cough
Berger’s Dz, IgA neprhopathy
1-2 weeks after sore throat
Post-strep CN
Hematuria + hemoptysis
Goodpastures - Abs to collagen IV
Heamturia + deafness
Alport, XLR collagen IV
Kid s/p viral URI with renal fialure, abdominal pain, arthralgia, and purpura
HS purpura, IgA, steroids
Kiddo after beef ingestion with diarrhea and renal failure, MAHA and petechiae
HUS E. Coli - no ABX - more toxin
Cardiac patient after ticlopidine w/t renal failure, MAHA, low plts, fever, and AMS
TTP - plasmapheresis, no platelets, differentiate from HUS/TTP by PT and PTT
c-ANCA kidney, lung, and sinus
Wegener’s Granulomatosis - need biopsy
p-Anca, renal failure, asthma, eosinophilia
Churg strausss - lung bx, steroid
P-anca, no lung involvement, Hep B
PAN, small/med arteries everywhere but lung
Kid w/t family hx of stones
Cysteine stones
Chronic indwelling foley stones and alkaline pee
Struvite stones with bacteria
Nephrotic patient suddenly develops flank pain
Renal vein thrombosis - peeins out AT III, protein Cand S, stat CT or U/S