Radiation protection Flashcards
Means of expressing dose
Radiation energy deposited in unit mass of tissue
-absorbed dose (Gray, Gy)(1Gy = 1J/kg)
Absorbed dose weighted for harmfulness of different radiations
-dose equivalent (Sievert, Sv)
Dose equivalent weighted for radiation susceptibility of different tissues. Mainly a measure of risk, rather than a physical dose
-Effective Dose (Sievert, Sv)
Tissue weighting factors: bone marrow, breast, colon, lung, stomach
0.12
Tissue weighting factors: bladder, oesophagus, gonads, liver, thyroid
0.05
Tissue weighting factors: bone surface, brain, kidneys, salivary glands, skin
0.01
Tissue weighting factors: remainder tissues
0.10
Summed total tissue weighting factors
1 = Whole body effective dose
Where does radiation come from?
14.3% medical
13.5% gamma from ground and buildings
11.6% internal (food)
10% cosmic
50.1% radon
0.5% other sources
(85% natural sources, 15% man-made)
Average annual UK background dose
2.5mSv
How can radiation affect DNA?
Directly: secondary electron breaks DNA strand
Indirectly: e- leaves trail of water molecules behind, highly reactive OH* free-radicals created in this way very damaging
Why is radiation so dangerous
Instantaneous whole body dose of 4Sv could potentially be fatal
!!!
Low risk
1 strand damage
High risk
Both strand breaks (more from indirect)
Consequences of DNA mutation
Mutation repaired –> viable cell
Cell death –> unviable cell
Cell survives but mutated –> cancer?
Cancer
Development of cancer has several stages, can take year
Cells not helpless, can repair DNA to some extent
Even in absence of radiation, each cell in body sustains 5-10000 DNA damage events an hour from constant onslaught of free radicals produced as by-product of reactions within cell
Two types of effect:
Deterministic and stochastic