Radiation Biology Flashcards
1
Q
Which type of radiation-induced DNA damage is most important for cell killing caused by exposure to ionizing radiation?
A
DNA double-strand breaks
2
Q
The main mechanism of cell death after irradiation is:
A
Mitotic catastrophe: cells with damaged DNA attempt to divide resulting in progeny with an incomplete genetic complement and are unviable.
3
Q
What is the annual dose limit for radiation workers?
A
0.05 Sv = 50 mSv = 5 rem
4
Q
Which radiolysis product of water is responsible for the molecular damage caused by the indirect action of ionizing radiation?
A
OH• (Hydroxyl radical)
5
Q
Cells in which phase of the cell cycle are most sensitive to radiation?
A
G2/M phase
6
Q
Cells in which phase of the cell cycle are least sensitive to radiation?
A
Late S phase
