Chemotherapy

Question 1

Which enzyme functions in alkylator-induced DNA repair

Answer 1

MGMT

Question 2

What are the solvents used for paclitaxel and docetaxel respectively that allow for IV administration?

Answer 2

Paclitaxel = Cremophor EL
Docetaxel = Polysorbate 80

These solvents cause severe hypersensitivity reactions in dogs and require significant pretreatment with antihistamines and steroids and prolonged infusion with continued monitoring.

New water soluble formulation of paclitaxel (Paccal Vet) may lead to increased use of this drug in vet med.

Question 3

Feline cutaneous MCT response to Lomustine?

Answer 3

20 cats: 2 CR, 8 PR = 50% ORR

Question 4

Which drugs are radiation sensitizers?

Answer 4

Doxorubicin, carboplatin, actinomycin D, gemcitabine

Question 5

What toxicity is associated with 5-FU in cats?

Answer 5

Fatal CNS toxicity

Question 6

Which anthracycline may be administered orally?

Answer 6

Idarubicin

Question 7

Why is cyclophosphamide relatively platelet sparing?

Answer 7

High levels of aldehyde dehydrogenase in the bone marrow (which deactivates cyclophosphamide)

Question 8

What is the active metabolite of cyclophosphamide?

Answer 8

Phosphoramide mustard

Question 9

Which chemotherapy agent must you give MESNA with?

Answer 9

Ifosfamide

Question 10

Which drugs are severe vesicants?

Answer 10

Doxorubicin, vinca alkaloids, mechlorethamine, actinomycin D