Rad-Onc High yeild Q's Flashcards
1
Q
Mutation seen in Ataxia-Telangiectasia like disorder
A
MRE-11
2
Q
Mutations seen in ataxia Telangectasia
A
ATM
ATR
DNA-PKs
3
Q
Cytokines involved in inflammation
A
IL-1
IL-6
IL-8
TNFa
4
Q
Decrease in dose rate causes increase in tumor cell kill by
A
reassortment
this is called inverse dose rate effect.
5
Q
OER is highest in which cell cycle phase
A
“S”
6
Q
OER is lowest in which cell cycle
A
“M”
7
Q
How do nitroimidazoles increase radiation efficiency?
A
They are hypoxic radiosensitizers
8
Q
How is Amifostine activated
A
Most tumor cells are deficient in alkaline phosphatase that is required to activate amifostine
9
Q
What is Amifostine
A
- free radical scavenger
- radioprotector
- Normal tissue selectivity due to its lack in tumor cells
10
Q
What is alpha/beta ratio
A
sensitivity to fractionation
11
Q
Relatlimab inhibits?
A
LAG-3
ReLAGlimab!!
12
Q
E-Cadherin
A
- critical adhesion molecule
- Loss of E-cadherin leads to cancer invasion and metastasis
13
Q
NCAM
A
- Neural adhesion molecule
- Same like E-cadherin
- Changes in NCAM will facilitate mets
14
Q
Integrin
A
- Cell surface receptors that mediate cell-extracellular matrix adhesion
- Crucial role in mets by facilitating the cell migration, invasion and survival in new environment
15
Q
TGF-B
A
- Is a target for cancer therapy
- when the signals are developed they inhibit mets, cause immunosuppression and alters tumor microenvironment
