L23 Chemotherapy and Radiation therapy

Question 1

Cisplatin

Answer 1

Cross link DNA breaks
Inhibits DNA synthesis
Effective in S phase

Question 2

Taxanes

Answer 2

binds to microTubules
Inhibits spindle apparatus
Increases stability
Mitotic inhibitor
Effective in G2/M Phase

Question 3

Bleomycin

Answer 3

Radiomimetic drug
G2 phase

Question 4

Platinum drugs

Answer 4

UV Mimetics

Question 5

Topotecan Irinotecan

Answer 5

Topoisomerase Inhibitors

Question 6

Antibiotics: Dactinomycin/Doxorubicin

Answer 6

DNA/RNA synthesis inhibitors

Question 7

Ifosfamide

Answer 7

Cell Cycle non-specific alkyl for H

Question 8

Antimetabolites

Answer 8

Analogues of normal metabolism

Question 9

hydroxyurea

Answer 9

Injected in vivo for cell cycle synchrony

Question 10

Cetuximab

Answer 10

Blocks EGFR receptor
TK phosphorylation - inhibits

Question 11

FTI: Farnesyl transferase inhibitors*

Answer 11

Inhibit the function of ras

Question 12

Avastin

Answer 12

mab Targets VEGF

Question 13

Mitomycin C

Answer 13

undergoes bioreduction
Increase activity under hypoxic conditions

Question 14

Drug resistance*

Answer 14

common: mdr gene
can be reversed with verapamil
are still radiosensitive

Question 15

mdr gene

Answer 15

these cells are not cross resistant to radiation

Question 16

chemo vs radiation

Answer 16

combo of RT and chemo
: Spatial cooperation
Different target cells
decrease tumor burden

Question 17

taxol and gamma rays

Question 18

Angiostatin

Answer 18

Endothelial cell function inhibitor

Question 19

interaction of chemo and radiation therapy

Answer 19

Question 20

EGFR inhibitors

Answer 20

Cetuximab
Transtuzumab