RAAS

Question 1

Which organ in the body produces angiotensinogen?

Answer 1

Liver

Question 2

What is the role of angiotensinogen?

Answer 2

It is the precursor to Angiotensin I

Question 3

What converts angiotensinogen into angiotensin I?

Answer 3

Renin

Question 4

Which organ produces renin?

Answer 4

Kidney when there is a lack of water

Question 5

Which enzyme converts angiotensin I into angiotensin II?

Answer 5

ACE (Angiotensin converting enzyme)

Question 6

Where is ACE found?

Answer 6

Lungs

Question 7

Which gland does angiotensin II act on?

Answer 7

Adrenal Gland

Question 8

What does the adrenal gland produce as a result of the action of ang II?

Answer 8

Aldosterone

Question 9

What is the role of aldosterone?

Answer 9

Aldosterone acts on the collecting ducts of the nephrons of the kidneys to retain water

Question 10

What does the retention of water do to the body?

Answer 10

Increases blood pressure

Question 11

What can angiotensin do to the heart?

Answer 11

Following an MI, ang II can remodel the heart in a bad way

Question 12

Name 3 drugs that act on the RAAS

Answer 12

ACE inhibitors
ARBs (Sartans)
Spironolactone

Question 13

Name the location of the mechanism of action for all three drugs within the RAAS.

Answer 13

ACE inhibitors act on ACE
ARBs (Sartans) act on the Angiotensin receptors in the adrenal gland
Spironolactone blocks the action of aldosterone