RAAS

Question 1

Renin inhibitors

Answer 1

Remikire
aliskiren

Question 2

All ACEI are carboxyl except

Answer 2

Captopril sulfhydryl
Fosinoprol phosphinate

Question 3

ACEI mnemonic

Answer 3

Captopril

Question 4

Which ACEI not prodrug

Answer 4

Capto lisino

Question 5

Capto bad. Coz

Answer 5

Less potent
Faster onset
Less duration
Less absorption in the presence of food

Question 6

Enalaprilat

Answer 6

Seperate drug used for hypertensive emergency IV

Question 7

ACEI use

Answer 7

HTN
CHF reduce both preload n afterload
Evolving MI- all MI patients
Diabeteic nephropathy and non diabtetic and hypertensive
Diabetic reitnipathy
Scleroderma crisis

Question 8

Adverse effects of ACEI

Answer 8

Cough
Angiodema
Rashes
Dysguesia
Acute renal failure
Hyperkalemia with beta blocker potassium sparing diuretics and NSAIDs

Question 9

Interactions of ACEI

Answer 9

Synergise with diuretic
Indomethacin attentiate hypotensive action
Indometh and diuretic plus ACEI renal failure
Hyperkal with some drug
Li toxicity

Question 10

How ACEI is foetopathic

Answer 10

Cause CNS defect in 1st trimester
Renal in 2nd n 3rd

Question 11

Ok

Question 12

Captopril test

Answer 12

To test whether hypertension is renovascular or essential. In renovascular there’s increase in PRA when captopril which is more than inc in essential

Question 13

CHF and MI mei sartan or pril

Answer 13

Pril preferred (ACEI)

Question 14

Lo sir and anti puri tax

Answer 14

Losartan anti platelet thry TXA2 antagonism
Uricosuric

Question 15

Ppar tell me sar GST lie?

Answer 15

Telmesartan
PPAR gamma activate —> help in dysglycemia
Dec insulin resistance

Question 16

Sartan same adverse affect n all as prill except angioedema and cough