Cough Flashcards
Central antitussive
Opioids: morphine codein pholcodeine
Non opioids: dextromethorphan noscapine
Antihistamine: cholpehniramine
Most effective centrala antitussuve
S/e
Alternative
Morphine
Addiction constipation and respi suppression
Phlocodeine
Antitussive
They are anti us
Call code
No escape
One of the 10 methods of being an orphan
Antitussive
Codeine
Noscapine
Dextromethorphan
Expectorant
Expect ki Gu au FNAC sambhal uncle
Expectorant
potassium iodide
Guaifenesi
Tolu balsam
NH4Cl
Guaifenesin
Secrets by trachebrocnhcial gland
Inc mucocilairy
And broncho secretion
Guaifenesin
Secrets by trachebrocnhcial gland
Inc mucocilairy
And broncho secretion
Only FDA approved drug
Potassium iodide
Interfere with TFT
Cause hypothyroid
Flaring up if acne
Mucolytics
I am brock lesner bro 6 time in the ring(cyst) i have dorned alpha title
Ambroxol is metabolite of bromohexine
Bromohexine
Acetylcydteine
Carbacysteine
Dornase alpha
MOA of mucolytics
Dornase alpha enzyme
-cysteine break disulphide bonds
Bromohexine depolymerises mucopolysaccharide
Bronchodilator for asthma
Sympathomimetics
Antichol
Methyl xanthine
Sympathomimetic for asthma
Salmbutamol terbutalaline r short acting
SalMETERolol and farma are long acting
Farma fast salma slow
Salma for prophylaxis
Farma for acute and prophylaxis
Adverse effects of sympathomimetics in asthma
TTTT
Tremor
Tachy–
T wave change due to hypikal
Tolerance mainly with long acting
Hyperglycemia
Methylxanthine
Inhibit PDE inc cAMP cause bronchodilation
Adenosine antagonism
PDE 4 antagonism
Histone deacetylase stimulation (so by sterioid)
IL 10 inc
Neutrophil apoptosis
Adverse effect of methyl xanthine
PDE gah ADEnosine
PDE mediated
GIT- vomiting nausea
A- arryrhmia due to Ca release from SR in high doses
H- Headache
A- arryrhmia
D- diuresis
E- epilepsy
C s stimulation causes delirim tremor n convulsion.
Gastric stimulation n CTZ irritation cause vomiting
Interactions of theophylline
Dose reduction in
Cyp inhibitors
Elderly
CHF
Hepatic insufficiency
Pneumonia
Dose inc in
Smokers
Children
Enzyme inducers
Use of methyl xanthine
Asthma COPD(more useful)
Reduce episodes of sleep apnea in children by improving contractility n relieving fatigue of diaphragm muscle
IgE
Ig eslam om ala is zum ab
IgE omalizumab
S.c. route
Mast cell stabilizer
Too much masti for oral, taken inhalational
Mast cro moh
And cro milke
Ki toh fun
Sodium cromoglycate
Nedocronil
Kitotifen
Corticosteroid
Inc beta 2 receptors
Inhibit phspholipase A2
Cause hoarsenss of voice and oral candidiasis (prevented by gargling and Nystatin)
Inhalational safe in preggo
Examples of corticosteroid
Flute muh mei buddhe seekhle become flutist solid
Fluticasone
Mometasone
Budesonide
Ciclesonide(soft steroid- reduced s/e due to metab in airway)
Beclomethasone(soft steroid)
Flutnisolide
Sterioid n ICS
Oral ke baad ICS to prevent withdrawal symptom
Systemic effect above 600- osteoprosis growth retard
Lipox inhibitor
Zileuton
Inhibit LTB4 C4 n D4 synthesis
Cause hepatotoxicity
LT receptors antagonistic
Monday telecast mei stress syndrome (valkai easy NO)
Montelukast zafirlukast
Churg Strauss syndrome- vascultisi with eosinophilia
IL 5
Like resilient poliz eosnophil ki M chd
Reslizumab
Mepolizumab
Monoclonal antibodies against IL 5
Inhibit eosinophil recruitment
