Dyslipdemia

Question 1

Source of hdl

Answer 1

Liver n enterocyte

Question 2

Pcsk 9 role

Answer 2

Target LDLR for degradation

Question 3

Scavenger rceeptor

Answer 3

SRB1

Question 4

CETP

Answer 4

Cholestrylester TG transport protein
Exchange TG n CE between HDL n vldl ldl

Question 5

Risk for CAD

Answer 5

Men above 45
Women above 55
Smoking HTN DM less than 40 HDL Ch in men 50 in women
More than 160 LDL Ch or overall Ch more than 240
BMI more than 25
Fam history MI or Sudden cardiac death before 55M or 65F in 1st degree relative

Question 6

Statins

Answer 6

Real american still love playing football
Statins end with -vastatin

Question 7

Type 2 hyperchol

Answer 7

Only Ch inc

Question 8

Most potent
Longest
Least potent
Max CNS permeability n prodrug

Answer 8

Pitava
Rosuva pitava
Fluva Lova
Simva lova

Question 9

Pleiotropic Effect of statin

Answer 9

Plaque stabilise
Endothelial dysfunction
Inflammation
Oxidative stress
Inflammation

Question 10

Adverse effect of statin

Answer 10

Myopathy n hepatotox
Hyperglycemia inc DM chance

Question 11

Pravastat

Answer 11

Metabolsed by non microsomal so min. Drug interactions
Minimum food interaction (others ka absorption inc by food)
Min myopathy n CNS penetration
Reduce Fibrinogen level

Question 12

Risk of statin induced myopathy inc with

Answer 12

Immunosuppresnet
Renal failure
Erythromycin ketaconazole
Fibrateold age
niacin

Question 13

Ezetimibe

Answer 13

Intersitnal chol absorb block
Inhibit NPC1L1
Sued for sitosterolemia
Reduce LDL C with statin

Question 14

Ezetimibe

Answer 14

Enterhepatic cycling

Question 15

Bile acid binding agent

Answer 15

Cholesterol hai i am tyred old man, tip evening lame
Hone vala hai BABA
Cholestyramine Colestipol: satchet
Colesevelam: tab

Question 16

DOC for cholestorl lowering in preggo children n during lactation

Answer 16

BABA

Question 17

BABA

Answer 17

Causes constipation
Also since normally bile acid reduce TG synthesis, it’s inc now. So used in 2a coz vahan chol is only increased.

Question 18

Fibric acid derivatives

Answer 18

Activates LPL by binding to PPAR
Best for dec LDL TG
Inc HDL

Question 19

Why clofibrate is not used

Answer 19

It causes post cholecystectomy complications
Gall stone formation
N malignancies

Question 20

Examples of fibric acid derivatives

Answer 20

Gemfibrozil
Fenifibrate: longest action n max lowering, uricosuric
Bezafibrate: does not cause myopathy with statin

Question 21

Fibric acid bad why

Answer 21

GI distress n aminotranferase inc
Myopathy with statin
Potentiate warfarin n oral hypoglycemic due to displacement frm PP binding n metab inhibit

Question 22

Fibrate use

Answer 22

Hypertriglyceridemia type 3
Also used in 4 5
Raised TG n low HDL- metab syndrome n TllD
First line of drug for inc in TG
Also reduce fibrinogen in blood like pravastatin

Question 23

Niacin

Answer 23

Dec ldl vldl and Inc hdl
Dec liporotein a
Dec fibrinogen

Question 24

Niacin cause HAGHUM

Answer 24

Hepatotox (seen as rduced LDL n HDL)
Hyperglycemia
Acanthosisi nigricansb
GI toxicity
Hyperuricemia
Maculipathy

Question 25

Reduced compliance of niacin

Answer 25

Cutaneous vasodilation and pruritus Dur to PGD2 Inhibited by givin aspirin or laroprirant

Question 26

Use of niacin

Answer 26

Control pancreatitis due to severe hypertriglyceridemia Given in type 4 n 5

Question 27

Max LDL lower Max tg lowering Max hdl Inc

Answer 27

Statin fibrate niacin

Question 28

Gugulipid

Answer 28

Ldl dec Hdl Inc Diarrhea

Question 29

CETP inhibitors

Answer 29

AnaCETRaPIb

Question 30

Mtp inhibitors

Answer 30

Reduce vldl Lomitapibe

Question 31

Mipomersen

Answer 31

Apo B mRNA antisense oligonucleotide

Question 32

Drugs for homozygous familial hypercholesterolemia

Answer 32

Mipomersen Evolocumab Lomitapide

Question 33

Evolocumab

Answer 33

Evolo pics kyu le rhe ho ab Monoclonal antibody for PCSK9