RA market-103 Flashcards
Biological DMARDs are bioengineered versions of normal immune components that work by a variety of mechanisms, including……
- Tumor necrosis factor
- Costimulation modulation
- Interleukin 6
- Interleukin 1
- B-cell targeted therapy
Name the TNFa Inhibitors
- Enbrel (etancercept)
- Humira (adalimumab)
- Remicade (infliximab)
- Simponi (golimumab)
- Cimzia (certolizumab pergol)
Which agents are Costimulation Modulator’s
Orencia (abate pet)
Which agents are IL-6 Inhibitors?
Actemra (tocilizumab)
Which agents are B-Cell Targeted Therapies
Rituxan (rituximab)
What is the dosing for Enbrel?
50mg weekly via subcu injection
What is the dosing for Humira?f
40 mg every other week via SC injection
- Some patients not asking MTX may derive additional benefit from increasing the dosing to 40mg every week.
What is the dosing for Remicade?
- Induction: 3mg/kg given as an IV infusion at 0,2, and 6 weeks
- Maintenace: 3mg/kg every 8 weeks
What is the dosing for Simponi?
50mg by SC injection once a month
What is the dosing for Cimzia?
400mg (given as two SC injections of 200mg) initially and at weeks 2 and 4, followed by 200mg every other week.
What is the dosing for Orencia?
Intravenous: 30-minute intravenous infusion given at 2 and 4 weeks after the first infusion and every 4 weeks there after…Dose is based on body weight.
SC: 125mg admits reed by SC once weekly and may be initiated with or without an IV loading dose
What is the dosing for Actemra?
IV: 60 minute single IV drip infusion; 4mg per kg every 4 weeks followed by an increase to 8 mg per kg every 4 weeks based on repsonse.
SC:
- Less than 100kg: 162 mg every other week
- At or above 100kg: 162mg every week.
What is the dosing for Rituxan?
IV- Two 1000 mg IV infusions separated by 2 weeks, in combo with MTX
TNFa inhibitors prevent TNFa from binding to_____________?
P55 and p75 cell surface receptors
The route of administration for MTX is___________?
Oral dose
Costimulation Modulator’s prevent the Costimulation signal required for_____________?
T-Cell Activation
Orencia is a _____________?
Costimulation Modulator
Which agent binds specifically to both soluble and membrane-bound IL-6 receptors, and has been shown ton inhibit IL-6 mediated signaling through these receptors?
Actemra
B-Cell targeted therapies bind to CD20, a cell marker expressed on mature and pre-B cells, leading to the depletion of CD20+ B cells via several mechanisms. This leads to:
A reduction in the inflammatory repsonse.
JAK inhibitors are small molecules that work by competing with_________and limiting JAK activity.
ATP—Adenosine triphosphate
STATS enter the cell nucleus, where they can affect the structure and expression of genes in a process called_____________
Transcription
JAKs have been identified as potential targets for new treatments because they are key regulators of several____________that have been implicated in RA development and progression
Cytokines
