RA market-103

Question 1

Biological DMARDs are bioengineered versions of normal immune components that work by a variety of mechanisms, including……

Answer 1

• Tumor necrosis factor
• Costimulation modulation
• Interleukin 6
• Interleukin 1
• B-cell targeted therapy

Question 2

Name the TNFa Inhibitors

Answer 2

1. Enbrel (etancercept)
2. Humira (adalimumab)
3. Remicade (infliximab)
4. Simponi (golimumab)
5. Cimzia (certolizumab pergol)

Question 3

Which agents are Costimulation Modulator’s

Answer 3

Orencia (abate pet)

Question 4

Which agents are IL-6 Inhibitors?

Answer 4

Actemra (tocilizumab)

Question 5

Which agents are B-Cell Targeted Therapies

Answer 5

Rituxan (rituximab)

Question 6

What is the dosing for Enbrel?

Answer 6

50mg weekly via subcu injection

Question 7

What is the dosing for Humira?f

Answer 7

40 mg every other week via SC injection

• Some patients not asking MTX may derive additional benefit from increasing the dosing to 40mg every week.

Question 8

What is the dosing for Remicade?

Answer 8

• Induction: 3mg/kg given as an IV infusion at 0,2, and 6 weeks
• Maintenace: 3mg/kg every 8 weeks

Question 9

What is the dosing for Simponi?

Answer 9

50mg by SC injection once a month

Question 10

What is the dosing for Cimzia?

Answer 10

400mg (given as two SC injections of 200mg) initially and at weeks 2 and 4, followed by 200mg every other week.

Question 11

What is the dosing for Orencia?

Answer 11

Intravenous: 30-minute intravenous infusion given at 2 and 4 weeks after the first infusion and every 4 weeks there after…Dose is based on body weight.

SC: 125mg admits reed by SC once weekly and may be initiated with or without an IV loading dose

Question 12

What is the dosing for Actemra?

Answer 12

IV: 60 minute single IV drip infusion; 4mg per kg every 4 weeks followed by an increase to 8 mg per kg every 4 weeks based on repsonse.

SC:

• Less than 100kg: 162 mg every other week
• At or above 100kg: 162mg every week.

Question 13

What is the dosing for Rituxan?

Answer 13

IV- Two 1000 mg IV infusions separated by 2 weeks, in combo with MTX

Question 14

TNFa inhibitors prevent TNFa from binding to_____________?

Answer 14

P55 and p75 cell surface receptors

Question 15

The route of administration for MTX is___________?

Answer 15

Oral dose

Question 16

Costimulation Modulator’s prevent the Costimulation signal required for_____________?

Answer 16

T-Cell Activation

Question 17

Orencia is a _____________?

Answer 17

Costimulation Modulator

Question 18

Which agent binds specifically to both soluble and membrane-bound IL-6 receptors, and has been shown ton inhibit IL-6 mediated signaling through these receptors?

Answer 18

Actemra

Question 19

B-Cell targeted therapies bind to CD20, a cell marker expressed on mature and pre-B cells, leading to the depletion of CD20+ B cells via several mechanisms. This leads to:

Answer 19

A reduction in the inflammatory repsonse.

Question 20

JAK inhibitors are small molecules that work by competing with_________and limiting JAK activity.

Answer 20

ATP—Adenosine triphosphate

Question 21

STATS enter the cell nucleus, where they can affect the structure and expression of genes in a process called_____________

Answer 21

Transcription

Question 22

JAKs have been identified as potential targets for new treatments because they are key regulators of several____________that have been implicated in RA development and progression

Answer 22

Cytokines