RA - Combo or Monotherapy

Question 1

NSAIDs & COX-2 Inhibitors

Answer 1

use in combination w/ DMARDs

Question 2

corticosteroids

Answer 2

NOT USED AS MONOTHERAPY

use in combination with DMARD

Question 3

NSAIDs and DMARDs have

Answer 3

steroid sparing effects

Question 4

Adalimumab (Humira)

Answer 4

Can be used alone OR in combination

Question 5

Golimumab (Simponi)

Answer 5

Used in combination with MTX

Question 6

Certolizumab (Cimzia)

Answer 6

Can be used alone OR in combination with non-BRM DMARDs

Question 7

Abatacept (Orencia)

Answer 7

Monotherapy OR in combination with DMARD (not with TNF inhibitors or IL-1 antagonists)

Question 8

Tocilizumab (Actrema)

Answer 8

Alone OR in combination with MTX or another DMARD

Question 9

Sarilumab (Kevzara)

Answer 9

Alone OR in combination with MTX or another DMARD

Question 10

Rituximab (Rituxan)

Answer 10

In combination w/ MTX

Question 11

Tofacitinib (Xeljanz & Xeljanz XR)

Answer 11

Alone

or w/ methotrexate or another DMARD

Not in combination with BRM, azathioprine or cyclosporine

Question 12

Baricitinib (Olumiant)

Answer 12

Alone

or w/ methotrexate or another DMARD

Not in combination with BRM, azathioprine or cyclosporine

Question 13

Upadacitinib (Rinvoq)

Answer 13

Alone

or w/ MTX or another non biologic DMARD

Not in combination with BRM, azathioprine or cyclosporine

Question 14

Anakinra (Kineret)

Answer 14

This is a BRM (do not use w/ TNFi or abatacept)

Selectively inhibits IL-1

(Can be used w/ MTX)

Question 15

Abatacept (Orencia) Facts

Answer 15

T cell co-stimulation

BRM