RA Flashcards
what are the 3 classes of DMARDS (disease modifying antirheumatic drugs)
conventional
targeted
biological
what are examples of csDMARDS
methotrexate
what are examples of tsDMARDS
tofacitinib
what are examples of bdMARDS
TNF-alpha blockers - infliximab
what is the first line choice for DMARD therapy
methotrexate - folic acid analog
what is the overall effect of methotrexate
increase in extracellular adenosine level
activation of adenosine A2s receptor
what are the side effects associated with methotrexate
nausea, vomitting
mouth, GI ulcers
hair thinning
how to reduce severity of side effects
give concomitant folic acid 12-24h after methotrexate
what can be combined with methotrexate for moderate to severe RA
tofacitinib
MOA of tofacitinib
non selective, Janus kinase pathway inhibitor
what are the side effects of tofacitinib
immunosupression
anaemia
hyperlipidaemia
what should tofacitinib NOT be combined with
bDMARDS - infliximab
what type of antibody is infliximab
chimeric monoclonal antibody
what are the side effects associated with taking infliximab
respiratory/skin infection
increased risk of lymphoma
leukopenia, aplastic anemia
what are the contraindications of taking infliximab
live vacc, hepB
what should be monitored when taking infliximab
latent ot active TB
