r h e u m p h a r m Flashcards
what are the 5 drug groups used in rheumatology
NSAID's corticosteroids DMARDs Biologics Drugs for osteoporosis
what are NSAID’s used for in rhuematology and SE
sx relief
GI disturbances
renal impairment
caution in patients with CVS risk and asthma
what are DMARD’s and what conditions are they used in
disease modifying antirheumatic drugs
suppress inflammation
used in RA, PsA, SLE, vasculitis
give examples of DMARD’s
hydroxychloroquine
methotrexate
sulfalazine
methotrexate, leflunomide and cyclophosphamide are contraindicated in…
pregnancy and breast feeding
which types of vaccines should be avoided in used of DMARD’s methotrexate, azahtioprrine, ciclosporin and leflunomide
live vaccinations
which vaccines are advised when taking DMARD’s
annual influenza
pneumococcal
give examples of biologics
infliximab
rituximab
what are the drugs for osteoporosis
co prescribe calcium and vit D.
oral bisphosphonates like alendronic acid
what are the drugs used for crystal arthritis
acute attacks = NSAID’s
colchicine
intra articular steroid injections can be used
prophylaxis = allopurinol = rate lowering therapy
what are the SE of methotrexate
Nausea - most common Oral ulcers, hair thinning Hepatitis, cirrhosis Pneumonitis
Bone marrow suppression
what are the SE of hydrochloroquine
GI disturbance - most common
Retinal pigmentation and loss of vision – rare but screening needed
No blood tests needed
what are the SE of sulfalazine
GI upset -most common Rash
Hepatitis
Bone marrow suppression
what are the SE of azathioprine
GI upset - most common Bone marrow suppression
what are the SE of cyclophosphamide
bone marrow suppression
infertility
increased cancer risk
