c a r d i o p h a r m Flashcards
candesatan is an
ARB - blocked AT1 receptors and therefore inhibits the effects of angiotensin ii
do not inhibit kinin breakdown so no dry cough
cardioselective vs non selective b blocker
bisoprolol = cardio selective
sotalol, propanolol = non selective
b blocker MOA
blocks b receptors
actions via b1 = reduce CO, hr and contractility, reduce bp
actions on b2 - Bronchi, GIT: SM relaxation
b blocker effects
↑ diastolic perfusion - ↓ O2 demand
- ↓ afterload
SE of b blocker
bronchospasm
hypotension, bradycardia
worsened raynauds - peripheral vasoconstriction
dihydropyridine ccb and action
amlodipine
nifidepine
arterial SM activity - vasodilation
non dihydropyridines
- ve inotropic effect (esp. verapamil)
- verapamil also slows conduction at av and sa nodes
verapamil
diltiazem
ccb se
flushing headache
ankle oedema
GTN moa and SE
NO donor with short and rapid onset
vasodilation = reduces preload
reduced bp inc postural
headache
syncope
what class of anti arrhythmic is flecainide
class 1c
what class of anti arrrrhythic is amiodarone
class iii
digoxin is a
cardia glycoside
anti platelets give examples
aspirin
clopidogrel
action of clopidogrel
thienopyridine
Irreversible adenosine R antagonist
- inhibits ADP-induced fibrinogen binding to GPIIb/IIIa
SE of clopidogrel
bleeding - GI or intecranial
GI upset
SE of aspirin
gastritis
gastric ulceration
bleeding
action of aspirin
irreversible non selective COX inhibitor
reduces platelet TXA2
reduced platelet activation
reduced platelet adhesion and aggregation
action of statins
HMC CoA reductase inhibitors = block rate liming step in cholesterol synthesis
reduced hepatocyte cholesterol and increased ldl receptors in liver = reduced ldl cholesterol
se of statins
myositis = check ck
deranged lfts
gi upset
describe the action of warfarin
inhibits vit k epoxide reductase
inhibit recycling of vit k = leads to functional vit k deficiency
inhibits synthesis of factors 2,7,9,10,c and s
heparin mode of action
Co-factor for ATIII:
inhibits factors 2, 10, 11 and 12.
how do thrombolytics work
Convert plasminogen → plasmin Plasmin breaks down fibrin
streptokinase
alteplase
