quotes from rosens notes.... lecture 7 Flashcards

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1
Q

which divisions of the lung conduct zone

A

bronchi
bronchioles
terminal bronchioles

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2
Q

what is the conduction zone for?

A

BULK movement of air
no respiratory function
helps defend the lungs

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3
Q

which divisions of the lung are respiratory (aka transitional)

A

respiratory bronchioles
alveolar ducts
alveolar sacs

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4
Q

what is the respiratory zone for?

A

gas exchange via the acinus

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5
Q

how does branching of bronchioles affect surface area?

A

it durastically increases surface area and thus, the air VELOCITY SLOWS down

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6
Q

what provides circulation in the alveolus

A

pulmonary artery, capillary bed and pulmonary vein

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7
Q

distance between blood and air in an alveolus

A

<0.5 microns. tiiiiny

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8
Q

what are some lung/respiratory system functions

A

humidification
warming
filtration

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9
Q

if your lung dries out, what happens

A

“dessication of respiratory surface … could lead to infection”

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10
Q

the URT filters air. what are the four sizes of particles?

where are those particles trapped?

A

larger than 10 microns ==> hairy nose
5-10 microns ==> sinuses, pharynx
2-5 microns ==> bronchioles
alveoli (this is where smoke goes)

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11
Q

where is mucous not present

A

mucous only goes as far as terminal bronchioles. this makes suspension of very fine particles in the acini very troublesome

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12
Q

how do you get rid of particulates

A

cilia ==> they beat and propel the mucous suspension toward pharynx
alveolar macrophages ==> phagocytic destruction of debris, microbes
sneezing and coughing

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13
Q

sneezing and coughing is effective for?

A

the first 12 ish branch points of the R. system

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14
Q

what space allows for lung mvmt

A

the intrapleural space couples the lung surface to the chest wall and diaphragm

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15
Q

what does the lung natrually wants to __ but we prevent it by __

A

collapse; the recoil force of the chest wall and diaphragm give it a slightly negative INTRAPLEURAL pressure, and zero INTRAPULMONARY pressure

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16
Q

how does a lung collapse

A

by exposing the chest cavity to atmospheric pressure
or
introducing air into the intrapleural space (pneumothorax)

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17
Q

majority of inspiration is due to? the rest is?

A

diaphragm (75%)

the rest is external intercostals, scalene, sternomastoid…. (thats not a muscle?)

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18
Q

why can you breathe without much resistance

A

there is a large cross sectional area of the LRT, (therefore, low TOTAL resistance to flow).
this set-up allows you to move large amounts of air with very small pressure differences

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19
Q

expiration at rest

A

due solely to recoil of elastic elements in lungs

they recoil until their force equals the force of the chest wall

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20
Q

inadequate expiration results in

A

limited USEFUL lung capacity

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21
Q

airway resistance =

A

how easily does air go throuigh the tracheo-bronchial tree?
> asthma
> CF

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22
Q

thoracic resistance examples

A

fractured rib

obesity

23
Q

surface tension tries to minimize?

A

surface area of the lyng

24
Q

compliance =

A

change in volume / change in pressure

25
Q

in alveoli what does DECREASED compliance try to do to your lungs? Compliance is inversely proportional to?

A

it tries to keep them closed (tries to collapse them). Compliance inversely related to surface tension. (increased tension= decreased compliance)

26
Q

what does surfactant do to the lung?

A

induces an AREA DEPENDANT effect on tension, which changes how water molecules interact
as a chemist, my (more accurate) definition is… “it helps water attract to other surfaces, thereby reducing waters attraction to itself… lowering tension”

27
Q

relationship between radius and pressure

A

a small R needs more pressure to blow up an alveolus

28
Q

what does surfactant do to:

work, compliance, tension

A
reduces work
increases compliance (aka decreases resistance)
decreases tension (compensates for small radius of alveoli)
29
Q

how do you get preemies to breathe

A

positive pressure vent.

> surfactant production begins @ 32 wks

30
Q

tidal volume=

A

NORMAL breath volume

aka TV

31
Q

expiratory reserve volume=

A

ERV; maximum volume of forced exhale AFTER NORMAL breathing

32
Q

inspiratory reserve volume =

A

IRV; maximum volume of forced inspiration AFTER NORMAL breathing

33
Q

vital capacity=

A

MAX volume you can INHALE and EXHALE

VC = TV + IRV + ERV

34
Q

residual volume =

A

RV; volume of air left in lungs AFTER MAXIMUM EXHALE

35
Q

functional residual capacity=

A
  • volume of air in lungs AFTER NORMAL EXHALE

- describes the balance of force between lung collapse and chest wall recoil

36
Q

downfall of vital capacity measurements

A

they are only static numbers, they don’t tell you anything about the flow of air in a lung

37
Q

how do you measure dynamic properties of a lyng? whats normal

A
  • forced expiratory volume (over 1 sec) and forced vital capacity; ** we did this in lab.
  • FEV / FVC should be about 0.8
  • useful for COPD and asthma
38
Q

what causes airway resistance

A
  • due to frictional loss of energy from walls of airways
39
Q

obstructive diseases

A

increased airway resistance and CO2 retention

40
Q

Asthma is an example of

A

bronchospastic or reversible obstructive condition because the increase in resistance is due to bronchocontriction

41
Q

exercise induced asthma

A
  • cough, wheezing, chest tightness
  • may be due to heat and water loss during rapid respiration
  • (or maybe just that it doesn’t bother you until you try do exercise)
42
Q

emphysema is an example of

A
  • irriverible obstructive condition
  • forced residual capacity increases and elastic work decreases
  • airway ressitance increases
  • tendency to retain co2
43
Q

what happens to FEV/FVC in obstructed airway

A
  • decreased ratio
  • result of increased airway resistance
  • in some cases you also have a loss of lung elasticity/recoil
44
Q

examples of restrictive diseases

A
  • atelectisis
  • consolidation
  • pleural effusion
  • respiratory distress syndrome
  • pneumothorax
  • ** i would add scoliosis and broken rib
45
Q

atelectesis =

A

collapse of part or entire lung

46
Q

cnosolidation =

A

filling of alvolar spaces with inflammatory exudates

47
Q

pleural effusion=

A
  • heart failure,
  • hypoproteinemia
  • infection
  • neoplasm
  • thoracocentesis
48
Q

respiratory distress syndrome

A

most common example of restrictive disease usually in premature babies, but also in :

  • near drowning
  • acid aspiration
49
Q

restrictive disease=

A
  • reduction of total lung capacity
  • although FEV/FVC increases, the absolute movement of be air decreases because the functional residual capacity decreases
50
Q

dead space =

A

volume of air in first 16 segments that does nothing for oxygen absorbtion…. only for air condutiobn

51
Q

to live, __ must be greater than ___

A

TV must be larger than dead space

52
Q

compare rapid shallow breaths to deep slow ones

A

volume wise, the two may move the same amount of air.

rapid breathing does not overcome the DEAD SPACE, so alveoli don’t oxygnate as well

53
Q

good analogy for dead space?

A

think about snorkeling with suuper long tube…. it wouldn’t work. you’d keep breathing the same air